One way of thinking about what differentiates a breast cell from a heart cell is that each cell type expresses
different subsets of genes.
In order for these unspecialized cells to acquire the characteristics that make a leaf cell different from a root cell or a blood cell different from a muscle cell, they must turn on
different subsets of genes to produce the proteins responsible for each cell type's distinctive properties.
Not exact matches
The method is based on the knowledge that
different tumors can be driven by
different subsets of cancer
genes.
The groups that evolved into bonobos, chimps, and humans all retained slightly
different subsets of this ancestral population's diverse
gene pool — and those differences now offer clues today to the size and range
of diversity in that ancestral group.
Our laboratory has assembled a comprehensive set
of tools for doing this, including mice with conditional ablation
of the Btla
gene in
different subsets of immune cells.
has done some work looking at the
different genes involved in differing parts
of lipid metabolism, it may well be there's a
subset of the population that does respond badly to saturated fat, just as there's a
subset that responds well to high carb low fat diets (obviously these are not mainstream responses or we could all go home!)
In concurrent studies, the team will examine the
gene expression profile
of subsets of patients with
different clinical outcomes to provide further insight into why certain dogs have more aggressive B - CLL and to identify possible drug targetable pathways to improve the treatment for this cancer.