Sentences with phrase «different transcription factors»

My research interests include investigating the role of RNA degradation in Drosophila development, investigating the impact of wounding in the Drosophila embryonic central nervous system, and investigating the effect of protein degradation on the activity of different transcription factors in neuronal fate decisions during nervous system development in Drosophila.

Several different transcription factors have been found that can directly reprogram one type of blood cell into another.

Using both computer modeling and laboratory experiments, they discovered that it was possible to enhance the production of individual components of the cell wall under certain stress conditions by regulating different transcription factors.

«What was really cool about this research was we've known for a long time that a lot of different transcription factors were involved, but it was hard to understand how all the pieces fit together,» said Jenny Mortimer, director of plant systems biology at the Joint BioEnergy Division, a part of the Department of Energy.

Remarkably, although mouse studies had indicated that different transcription factors were differently important for generating pain and itch sensing neurons versus pressure and limb position neurons, in the dish these factors produced equal numbers of each of the three main subtypes.

Any conclusions regarding occupancy of a single strand of DNA by different transcription factors is based on inference.

Not exact matches

Transcription factors are responsible for either inhibiting or promoting the expression of genes, and master regulatory transcription factors are like transcription factors on steroids: their actions regulate thousands of genes in different kiTranscription factors are responsible for either inhibiting or promoting the expression of genes, and master regulatory transcription factors are like transcription factors on steroids: their actions regulate thousands of genes in different kitranscription factors are like transcription factors on steroids: their actions regulate thousands of genes in different kitranscription factors on steroids: their actions regulate thousands of genes in different kinds of cells.

For example, Capsaspora activated transcription factors and a tyrosine - kinase signaling system in different stages to regulate protein formation.

The transcription factor Gcn4 is conserved in over 50 different organisms, including mammals, and it likely play a significant role in the aging of these organisms as well.

Imagine the consequences if some of those piddly nucleotide changes arose in a protein that happened to be a transcription factor: Suddenly, instead of activating 23 different genes, the protein might charge up 21 or 25 of them — or it might turn on the usual 23 but in different ratios than normal.

Specifically, the data reveal distinct transitions in factors that influence the different cellular states including cell cycle regulators, transcription factors, and signaling factors.

The genes for each transcription factor were made from different bits of DNA that code for the functional parts of proteins, such as a domain that can bind to DNA and another that provides the protein with access to the cell's nucleus.

Until this study, researchers weren't able to manipulate production of the different components independently of each other, since many of the transcription factors, proteins that bind to the plant's DNA and regulate gene expression, are redundant.

Using computational methods, researchers applied that information to reconstruct the transcription factor networks responsible for medulloblastoma subtype diversity and identity, providing previously unknown insights into the regulatory landscape and transcriptional output of the different medulloblastoma subtypes.

We demonstrated the technique on 20 different biological processes spanning four orders of magnitude in space and time, including the binding kinetics of single Sox2 transcription factor molecules, 3D superresolution photoactivated localization microscopy of nuclear lamins, dynamic organelle rearrangements and 3D tracking of microtubule plus ends during mitosis, neutrophil motility in a collagen mesh, and subcellular protein localization and dynamics during embryogenesis in Caenorhabditis elegans and Drosophila melanogaster.

Another past study from Yoo's team showed that exposure to the same two microRNAs, miR - 9 and miR - 124, plus a different mix of transcription factors could turn skin cells into a different type of neuron.

Environmental factors interact with the different subgenomes to modify the transcription of their component genes and to modulate the translation of protein products and their posttranslational modification, yielding changes in protein and cellular function and metabolism, and defining an intermediate phenotype.

Ellen V. Rothenberg and Susan B. Ward report that the interleukin - 2 (IL - 2) transcriptional apparatus integrates multiple types of biochemical information in determining whether or not the gene will be expressed, using multiple diverse transcription factors that are each optimally activated or inhibited by different signaling pathways.

«We wanted to understand how stem cell transcription factors were interconnected and explain how these cells behave in different culture conditions and still maintain the stem cell state,» said Smith.

Han et al. demonstrated that in Caco2 cells, extracellular NAD + inhibited the binding of NF - kB to DNA by blocking the transcription of different genes involved in both inflammatory and aging pathways (interlukin - 6, interlukin - 1 beta, tumor necrosis factor alpha) 27.

The Rel subunit of NF - kappaB - like transcription factors is a positive and negative regulator of macrophage gene expression: distinct roles for Rel in different macrophage populations.

We want to understand how different RFX transcription factors are required for ciliogenesis control and how they are involved in ciliary specialization in mouse tissues.

Distinct transcription factor networks predicate different tumor identities, corresponding to sympathetic noradrenergic or mesenchymal / neural - crest cell like identities.

Transcription factors are expressed (or made) at different levels in different cell types, and control what genes are expressed in every cell, making sure, for example, that a liver cell remains a liver cell and does not become a neuron.

May 25, 2000 Different levels of transcription factor coax immune cell progenitors down different developmental pathways Researchers from the University of Chicago provide evidence that varying levels of a single transcription factor can determine the fates of developiDifferent levels of transcription factor coax immune cell progenitors down different developmental pathways Researchers from the University of Chicago provide evidence that varying levels of a single transcription factor can determine the fates of developidifferent developmental pathways Researchers from the University of Chicago provide evidence that varying levels of a single transcription factor can determine the fates of developing cells.

The proteins, called transcription factors, can combine in nearly limitless ways to target different genes, generating a rich regulatory syntax.

The transcription factor recognizes several different drugs and, in turn, triggers the expression of a transporter that pumps the drugs out of the cell.

As a transcription factor, p53 protein can be covalently modified by different enzymes.

A network of transcription factors may drive different subtypes of aggressive bladder cancer, allowing researchers to turn one type of tumor into another

Like transcription factors, these genes turn on other stem cell genes and turn off those associated with different cell types.

HSF4 belongs to a family of heat shock transcription factors that regulate the expression of heat shock proteins in response to different stresses, such as oxidants, heavy metals, elevated temperatures and bacterial and viral infections [96].