Sentences with phrase «different tumor genes»

Not exact matches

In a study published in Neoplasia, researchers at the Washington University School of Medicine created a map showing which genes were switched on and off in different parts of the tumor, providing a «signature» of these switches throughout the genome.

The genome - wide epigenetic changes clustered in certain chromatin domains and controlled «gene expression changes that specify different malignant traits, including the ability to form tumors,» McDonald said.

The expression of all human genes was analyzed in these tumors and correlated with different clinical parameters.

PTEN prevents tumor cells from growing uncontrollably, and mutations in the gene encoding this protein are commonly found in many different types of cancer.

African - Americans, on the other hand, experienced heightened mutations in BCL7A, a different tumor suppressor gene.

They tested these drugs one at a time for lethal interaction with 112 different tumor - suppressor gene mutations in human cancer cells growing in the lab.

In this mouse model, mutations in Kras and p53 genes resulted in the formation of individual tumor cell populations that were labeled with different colors.

Curious about the possibility of circular RNAs contributing to cancer, Pandolfi and his colleagues set out to see if they could detect relevant changes in tumors known to harbor distinct fusion proteins, which result when different chromosomes abnormally join together, melding two separate genes into a new centaur - like gene.

The resulting «map» of gene - drug interactions allowed the researchers to accurately predict the responses of multiple human cancer cell lines to different chemotherapy agents based on the cell lines» genetic profiles and also revealed new genetic factors that appear to determine the response of breast and ovarian tumor cells to common classes of chemotherapy treatment.

Unfortunately, in some cases, the tumor uses different epigenetic mechanisms, independent of estrogen, to repress the HOXC10 gene.

Both Tsigelny and Kurzrock agreed that this finding is an excellent example of the power of collaboration between SDSC and the Moores Cancer Center, and that such modeling needed to be studied across tumors and with multiple different genes involved in cancer.

This same feature, tumor heterogeneity, may reduce the ability to identify critical gene expression changes when comparing mean gene expression in adjacent tumor and normal tissues, as tumors of the same type may have different sets of genes differentially expressed.

Surprisingly, they found that although the patterns of gene expression — as shown by the RNA sequencing — differed between the hepatocellular carcinomas and the liver cancers with biliary phenotype and depended on the histological type, the overall pattern of mutations in the cells was actually similar between the tumors — of either type — that had emerged in patients who had had infections with either hepatitis C or B, and were different in patients without such infections.

The method is based on the knowledge that different tumors can be driven by different subsets of cancer genes.

Put simply, the pattern of microRNA genes turned on in one kind of tumor was entirely different from the pattern in another kind of tumor, and entirely different again from that seen in healthy cells.

They're continuing to sequence prostate tumors to learn how frequently different mutations occur, as well as studying which of the rearranged genes are actually driving cancer.

The team also found that these genes had different functions in promoting metastasis: One group encouraged growth of tumor cells in both breast and lungs, whereas the other only helped the new tumor thrive in the lungs.

Within this cascade Shp2 turns on different signaling molecules, but turns off the tumor suppressor genes p27 und p53.

Many tumor suppressor and receptor genes have been reported to be hypermethylated and transcriptionally silenced during the development of different types of cancers.

A research team led by Kerstin Lindblad - Toh at Uppsala University / SciLifeLab has used genetic analyses of 25 different dog breeds to identify genes that could have a role in the development of brain tumors.

Han et al. demonstrated that in Caco2 cells, extracellular NAD + inhibited the binding of NF - kB to DNA by blocking the transcription of different genes involved in both inflammatory and aging pathways (interlukin - 6, interlukin - 1 beta, tumor necrosis factor alpha) 27.

The federal government is launching a very different kind of cancer study that will assign patients drugs based on what genes drive their tumors rather than the type.

Dendritic cells reconstituted with human telomerase gene induce potent cytotoxic T - cell response against different types of tumors.

The research also showed that gene expression patterns of individual tumors varied considerably, and could exceed the variation observed between different cancer types.

In these deadly dispersed tumors, Trotman and his colleagues were surprised to find that a different cancer gene, called Myc, had taken over.

Resolve the genomic diversity in a variety of tumors by targeting hotspots across 50 oncogenes and tumor suppressor genes relevant in a range of different solid tumors with SNV and indel mutation detection.

Lemmon is collaborating with oncologists at Penn who have sequenced the ALK gene in nearly 2000 neuroblastoma tumors and found 50 different mutations.

Krogan believes that mutations in a few key networks of genes cause diseases like cancer, even though the individual genes that are mutated in tumors vary between different people and different types of cancer.

Examples include the study of allelic variation in the human genome and the development of computational methods for the discovery of cancer - associated genes and diagnostic cancer markers using genomic profiles derived from different tumor types.

Do they all impinge on some final common pathway and does the tumor specificity reside in the fact that in different tissues, there are different redundancies so that a particular gene may have a redundant helper in some tissues but not in others?

There are several different treatments being compared, including: surgery followed by vaccine - based immunotherapy, surgery followed by oncolytic virus therapy, surgery followed by IL - 12 gene therapy and biopsy followed by placement of a specialized catheter system that draws tumor cells out of the brain.