Sentences with phrase «different tumor types»

Cell lines are therefore indispensable in medical research and a large number of cell lines exist that originate from many different tumor types.

Ultimately, this knowledge may shift the paradigm of treating specific cancers of origin such as breast, lung and colon to treating unique mutations shared by many different tumor types.

The use of targeting antibodies against vascular endothelial growth factor (VEGF), a protein that promotes tumor growth and spread, plus chemotherapy has prolonged disease free survival in several different tumor types in man.

Expression of VEGF has been reported in a wide range of different tumor types in the dog including hemangiosarcoma, malignant melanoma, soft tissue sarcomas, mast cell tumors, nasal carcinomas, intracranial neoplasias, and simple mammary gland adenocarcinomas and inflammatory mammary carcinoma.

To develop the methodology, the group analyzed the molecular profiles of human embryonic stem cells and compared them with data for 12,000 samples of 33 different tumor types held by The Cancer Genome Atlas (TCGA), a US public database.

«It was hard to find a single microRNA in the human genome that wasn't differentially turned on or off across different tumor types in different tissues,» Golub says.

The Cancer Center has a history of significant advances in cancer genetics, cancer biology, tumor immunology, and virology, including the identification of genes associated with different tumor types, the development of monoclonal antibodies used to study pathways and proteins involved in tumor development, and contributions to improved cancer treatments and diagnostic tests.

Examples include the study of allelic variation in the human genome and the development of computational methods for the discovery of cancer - associated genes and diagnostic cancer markers using genomic profiles derived from different tumor types.

Hadfield and his colleagues are doing large - scale genomic analyses of different tumor types, as part of the massive Genomics England project to sequence 100,000 British genomes.

To develop the methodology, the group analyzed the molecular profiles of human embryonic stem cells and compared them with data for 12,000 samples of 33 different tumor types held by The Cancer Genome Atlas (TCGA), a U.S. public database.

Using a combination of experimental and mathematical studies, the Moffitt researchers identified two different cell populations that co-exist in many different tumor types; an aggressive cell population that can invade the surrounding space and migrate to form metastases, and a non-invasive cell population that is prone to stay in one place and help produce blood vessels.

They found that this substance had some effect on up to 40 different tumor types.

Drugs that inhibit STAT5 are a great hope for the treatment of many different tumor types.

Several drugs that target TIM - 3 are currently being studied in early stage clinical trials in different tumor types, including breast cancer.

The potential here is huge to apply this to different tumor types.»

Both drugs have shown promising activity as single - agents in a variety of clinical studies in different tumor types, and it has been hypothesized that combining these two drugs may result in added clinical benefit.

Hotspots of KRAS mutations are found in different tumor types and can serve as tumor rejection epitopes.

Merck has high hopes for pembrolizumab, which is currently being evaluated in more than 30 different tumor types.

Although cancer stem cells have been identified in many different types of cancer, it is becoming increasingly clear that the properties of these cells may vary greatly among the different tumor types.