Sentences with phrase «differential methylation»
"Differential methylation" refers to differences in the addition of a chemical group called a methyl group to DNA molecules. Methyl groups can influence gene expression, and when the pattern of methylation varies between individuals or groups, it is known as differential methylation. This can potentially indicate changes in gene activity or function, which can be relevant in various biological processes and diseases. Full definition
However, 15,627 CpG sites in / near ∼ 30 % of all genes exhibited differential methylation in adipose tissue from a case - control cohort of unrelated individuals, supporting a key role for epigenetic modifications in T2D patients.
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We further tested whether any individual sites exhibit differential methylation in the discordant twins.
A. Co-clustering of differential methylation among the protocadherins genes.
These genes were selected based on the following criteria: they exhibit differential expression in the discordant twins (q < 0.15; Fig. 3A and C), as well as differential methylation in both the discordant twins (P < 0.05; Fig. 3B and D) and case - control cohort 2 (q < 0.15; Fig. 3B and D).
We found differential methylation in 123 sites (q < 0.15) representing 50 T2D candidate genes including IRS1, PPARG, KCNQ1, and TCF7L2 (Supplementary Table 14 and Fig. 2K).
Meaney and colleagues have found that variation in early care affects the expression of the glucocorticoid receptor gene in the hippocampus by differential methylation of the promoter region of the gene leading to stable differences in offspring stress reactivity persisting through adulthood [136].
Our use of a false discovery rate of 0.2 as a threshold for calling differential methylation implies that we expect at most 20 % of our calls to be erroneous.
FINDINGS The authors picked up 21 novel sites of differential methylation, 15 of which occur only in the placenta — and none of which were imprinted in mouse crosses they conducted (Genome Res, 24:554 - 69, 2014).
The validation of these differentially methylated promoters in a distinct human sample, and of a different sex, is consistent with the hypothesis that chronic physical aggression is associated with differential methylation in these promoters.
Using a new bioinformatics tool, they identified HAND2 as a differential methylation hotspot in endometrial cancer.
Interestingly, differential methylation of the protocadherin cluster was also found to be associated with childhood socioeconomic position in whole blood [85] and with differential maternal care early in life in hippocampi of rats [33].