Sentences with phrase «differentiate into any human cell»

Pluripotent stem cells are the most potent type of stem cells; they have the ability to differentiate into any human cell type and to reproduce indefinitely.

Not exact matches

How else can microscopic cells evolve and differentiate into a fully formed human?

Stem cells have also been identified in human milk, and have the potential to differentiate into mammary epithelial lineages under mammary differentiation conditions in vitro, as well as other cell types in corresponding microenvironments, including bone cells, brain cells, liver cells, pancreatic beta cells and heart cells.

Scientists headed by Dr. Stevens Rehen differentiated human induced pluripotent stem (iPS) cells into neural stem cells and into further complex tridimensional structures, known as neurospheres and brain organoids.

As it can take weeks to grow human cells into intact differentiated and functional tissues within Organ Chips, such as those that mimic the lung and intestine, and researchers seek to understand how drugs, toxins or other perturbations alter tissue structure and function, the team at the Wyss Institute for Biologically Inspired Engineering led by Donald Ingber has been searching for ways to non-invasively monitor the health and maturity of cells cultured within these microfluidic devices over extended times.

Tufts University biomedical engineers recently published the first report of a promising new way to induce human mesenchymal stem cells (or hMSCs, which are derived from bone marrow) to differentiate into neuron - like cells: treating them with exosomes.

One likely reason for this is that animals undergo cellular differentiation; human life begins as a single cell that differentiates into the various cell types needed for different organs, body parts, blood, the immune system, etc..

The results obtained by Afsaneh Gaillard's team and that Pierre Vanderhaeghen at the Institute of Interdisciplinary Research in Human and Molecular Biology show, for the first time, using mice, that pluripotent stem cells differentiated into cortical neurons make it possible to reestablish damaged adult cortical circuits, both neuroanatomically and functionally.

Now, scientists at Boston University's Center for Regenerative Medicine (CReM) have announced two major findings that further our understanding of this process: the ability to grow and purify the earliest lung progenitors that emerge from human stem cells, and the ability to differentiate these cells into tiny «bronchospheres» that model cystic fibrosis.

But with humans, she is using iPS cells and has been working to develop the correct protocols to induce her stem cells to differentiate into different kinds of lung tissue.

Finally, they demonstrated that zebrafish OPCs differentiate into mature oligodendrocytes when cultured together with human motor neurons, differentiated from induced pluripotent stem cells.

- Our results provide new insights into the mechanisms of how POLR3G gene regulates stem cell state, which in turn sheds light on the complex mechanisms with which human embryonic stem cells both self - renew and maintain the ability to differentiate.

Adult organisms ranging from fruit flies to humans harbor adult stem cells, some of which renew themselves through cell division while others differentiate into the specialized cells needed to replace worn - out or damaged organs and tissues.

While stem cells — cells that have the potential to differentiate into other types of cells — exist in adult humans, the most useful stem cells are those found in embryos, which are pluripotent, capable of becoming nearly any cell in the body.

During embryonic development, organ - specific cell types are formed from pluripotent stem cells, which can differentiate into all cell types of the human body.

«Our focus here has been on early heart development, but the basic principles of patterning of human pluripotent stem cells, and subsequently differentiating them, can be readily expanded into a broad range of tissues for understanding embryogenesis and tissue morphogenesis,» said Healy.

They found that the model's stem cells differentiate (specialize) into the various cells of the brain in the same way that they do in the first trimester of human development.

Recent research by neuroscientist Fred Gage and colleagues at the University of California (UC), San Diego, has shown that one of the most common types of jumping gene in people, called L1, is particularly abundant in human stem cells in the brain that ultimately differentiate into neurons and plays an important role in regulating neuronal development and proliferation.

RIKEN researchers have taken up this challenge, and the work published in Cell Reports details how sequentially applying several signaling molecules to three - dimensional cultures of human embryotic stem cells prompts the cells to differentiate into functioning cerebellar neurons that self - organize to form the proper dorsal / ventral patterning and multi-layer structure found in the natural developing cerebellum.

Using a process called cellular reprogramming, the researchers take a patient's skin cells, convert them into so - called induced pluripotent stem (iPS) cells, which can differentiate into all the cells within the human body.

«Our focus here has been on early heart development, but the basic principles of patterning of human pluripotent stem cells, and subsequently differentiating them, can be readily expanded into a broad range of tissues for understanding embryogenesis and tissue morphogenesis,» said Dr. Healy.

«The region selective - state of these stem cells is entirely novel for laboratory - cultured stem cells and offers important insight into how human stem cells might be differentiated into derivatives that give rise to a wide range of tissues and organs,» says Jun Wu, a postdoctoral researcher in Izpisua Belmonte's lab and first author of the new paper.

Lamba and colleagues recently demonstrated that human embryonic stem cells could be directed to differentiate into photoreceptors and respond to a light stimulus as measured by ERG in crx − / − mice (a model for Leber's congenital amaurosis)[5].

«ViaCyte was the first to differentiate human stem cells into glucose - responsive, insulin - producing cells, and now we are running the first and only clinical trials of stem cell - derived islet replacement therapies for type 1 diabetes,» said Paul Laikind, PhD, President and CEO of ViaCyte.

In the paper, published May 6, 2015 in Nature, the scientists report using these new stem cells to develop the first reliable method for integrating human stem cells into nonviable mouse embryos in a laboratory dish in such a way that the human cells began to differentiate into early - stage tissues.

Presently, human pluripotent stem cells (hPSCs) are the most powerful cellular resource to challenge this complete reassessment of the scientific bases and goals of toxicity testing, since they present a unique opportunity to develop a wide variety of human cell - based physiological test systems because they may be expanded indefinitely and triggered to differentiate into any cell type, offering additionally the possibility to represent the human population diversity.

Human ES cells treated with Noggin, Dickkopf - 1, and Insulin - like Growth Factor - 1 proteins differentiate into functional photoreceptors [5].

They have already shown that they can transform human fibroblast cells into pluripotent stem cells, and now plan to start working on delivering the proteins needed to differentiate stem cells into specialized tissues.

Here we show that it is feasible to differentiate and mature human embryonic stem cells (hESCs) into functional -LSB-...]

Typically, this involves creating a «scaffold» of natural or synthetic materials, seeding it with human stem cells that can differentiate themselves into particular tissue types, and providing the cells with nutrients and a physical environment that encourages them to take on the three - dimensional structures and functions of a particular body part.

Human mesenchymal stem cells (hMSCs) are currently the most common adult stem cell type used for cell therapy applications due to their regenerative properties and ability to differentiate into multiple cell lineages (adipocyte, chondro ¬ cyte, and osteocyte).

The group recently produced data showing that stem cells from human hair follicles also differentiate into contractile smooth muscle cells.

Unlike other cell types, stem cells are unspecialized cells uniquely capable of making copies of themselves (self - renewing), differentiating into specialized cell types, and helping to maintain some tissues in the human body.

He and colleagues have also succeeded in differentiating human pluripotent stem cells into retinal (RPE) cells, and has shown that they provide long - term benefit in animal models of vision loss.

If they were permanent, ES cells would never be able to differentiate into heart, kidney, brain, bone, skin and the other specialize cells crucial to normal human functioning.

A trial being conducted by Advanced Cell Technology is testing the effectiveness of MA09 - hRPE, human ESCs terminally differentiated into retinal pigment epithelial (RPE) cells, in treating degenerative macular diseases.

Researchers at UCSB were able to make these human iPS cells differentiate, or turn into, retinal cells.

The self - renewable capacity of these cells, their ability to differentiate into several tissue progenitors (neural, mesenchymal stem cells...), and the possibility to work with mutated cell lines define human stem cells as a good basis for screening compounds libraries in order to discover new potential drugs for monogenic diseases.

To do this, human stem cell lines could be treated to differentiate into human heart cells in a dish.

Researchers have shown that human induced pluripotent stem cells can differentiate and self - organize into cardiac microchambers when spatially confined.

We have recently developed the use of site - specific nucleases to genetically engineer human pluripotent stem cells, which can be maintained indefinitely and differentiated into any cell type of interest.

The Herlyn lab is differentiating multi-potent stem cells from the human dermis and reprogrammed stem cells into melanocytes to test the hypothesis that melanocyte stem cells are more prone to transformation than fully differentiated cells, and that neighboring cells and matrix in the microenvironment play critical roles in differentiation and transformation.

Furthermore, human NSC - derived pluripotent stem cells can differentiate into all three germ lineages both in vitro and in vivo.

In a study using human muscle tissue, scientists in Children's Stem Cell Research Center - led by Johnny Huard, PhD, and Bruno Péault, PhD - isolated and characterized stem cells taken from blood vessels (known as myoendothelial cells) that are easily isolated using cell - sorting techniques, proliferate rapidly and can be differentiated in the laboratory into muscle, bone and cartilage ceCell Research Center - led by Johnny Huard, PhD, and Bruno Péault, PhD - isolated and characterized stem cells taken from blood vessels (known as myoendothelial cells) that are easily isolated using cell - sorting techniques, proliferate rapidly and can be differentiated in the laboratory into muscle, bone and cartilage cecell - sorting techniques, proliferate rapidly and can be differentiated in the laboratory into muscle, bone and cartilage cells.

Through extensive examination, we have shown that human NSC - derived iPS cells are phenotypically identical to hESCs by all pluripotential markers analyzed and for their ability to differentiate into all three major germ lineages.

Human embryonic stem cells differentiate into a homogeneous population of natural killer cells with potent in vivo antitumor activity.

Stem cells have the capacity to differentiate into any of the different tissues making up the human body, thus holding the promise of treating or curing diseases such as multiple sclerosis or spinal - cord injury by replacing diseased cells with healthy cells.

Following this, they demonstrated that neural progenitors from embryonic stem cells could differentiate themselves into neurons in rat brains presenting lesions similar to those observed in humans.

Saxena, Pratik, et al. «A programmable synthetic lineage - control network that differentiates human IPSCs into glucose - sensitive insulin - secreting beta - like cells.»

Finally, we used this approach to encapsulate human Neural Stem Cells (hNSC) derived from human Induced Pluripotent Stem Cells (hIPSC), which were further differentiated into neurons within the capsules with negligible loss of viability.