Sentences with phrase «differentiated cells in a tissue»

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Cultured in the lab, the changed cells showed an ability to differentiate into (or become) two discrete cells found in breast tissue.

In past projects, scientists have tried to derive various types of differentiated cells from stem cells — such as bone, tissue, nerves or fat — directly from hiPSCs.

One of the key questions in biology is to identify how tissues are repaired after trauma and understand how stem cells migrate, proliferate, and differentiate to repair tissue damage.

The committee says the 14 - day mark is an appropriate limit as the cells of the embryo are not yet differentiated into tissues, in that there is no organized development.

This work stems from a previous study by Varghese's group to understand how calcium phosphate minerals found in bone tissue induce stem cells to differentiate into osteoblasts.

Once stem cells can be grown and differentiated in a controlled way to replace degenerated cells and repair tissues, medical science may then be able to diagnose and cure many intractable diseases at their earliest stages, such as type 1 diabetes, Parkinson's disease, various cardiovascular diseases, liver disease, and cancer.

They also applied it to human brain tissue collected by the Genotype - Tissue Expression (GTEx) Project, finding that they could a) identify expression signatures unique to neurons, glial cells, and other cell types in the brain (including rare types), and b) differentiate between closely related cell subtissue collected by the Genotype - Tissue Expression (GTEx) Project, finding that they could a) identify expression signatures unique to neurons, glial cells, and other cell types in the brain (including rare types), and b) differentiate between closely related cell subTissue Expression (GTEx) Project, finding that they could a) identify expression signatures unique to neurons, glial cells, and other cell types in the brain (including rare types), and b) differentiate between closely related cell subtypes.

In Arabidopsis, as in most plants, there is a specific zone near the tip of the root where stem cells transition from a stage of proliferation to one where they differentiate into specific tissue typeIn Arabidopsis, as in most plants, there is a specific zone near the tip of the root where stem cells transition from a stage of proliferation to one where they differentiate into specific tissue typein most plants, there is a specific zone near the tip of the root where stem cells transition from a stage of proliferation to one where they differentiate into specific tissue types.

In a study published online in Circulation Research late last year, Chaudhry and colleagues found that fetal cells in mice migrated to the mother's heart, differentiated into functioning cardiac cells, and accelerated repair to damaged heart tissuIn a study published online in Circulation Research late last year, Chaudhry and colleagues found that fetal cells in mice migrated to the mother's heart, differentiated into functioning cardiac cells, and accelerated repair to damaged heart tissuin Circulation Research late last year, Chaudhry and colleagues found that fetal cells in mice migrated to the mother's heart, differentiated into functioning cardiac cells, and accelerated repair to damaged heart tissuin mice migrated to the mother's heart, differentiated into functioning cardiac cells, and accelerated repair to damaged heart tissue.

During development, as an embryo forms differentiated tissues, liver cells, brain cells, muscle cells, the cells in those tissues begin to allow for the selective expression of genes contained in those same 3 billion nucleotides.

«We've demonstrated definitively that, once the cells are differentiated, the immune response to iPS - derived cells is indistinguishable from its response to unmodified tissue derived from elsewhere in the body,» said Kooreman.

In addition, we were able to differentiate these cells into neurons — and that's a characteristic of all neural crest - derived tissue and its progenitors»

In response to such injury, however, stem cells have to be able to rapidly divide, to generate daughter cells that differentiate into cells that repair the tissue.

Easily accessible from nasal biopsies, these cells — which belong to nerve tissues and can differentiate into neurons — constitute an interesting model to identify the genes and proteins whose expression is deregulated in patients with ASD.

So, at the dawn of our universe — and I have to emphasize our universe, because there could be others — so, dawn of our universe, physicists think there was one type of force, one type of matter and that as the cosmos expanded, as space expanded, it cooled and things started to condense out like snow flakes, and over time that single force broke, it differentiated; and something similar happens in the human body as we develop from a single cell; we differentiate, different tissues form in our bodies, different layers of tissues.

In experiments to be published Tuesday, July 14, in the journal Nature Communications, the researchers used biochemical and biophysical cues to prompt stem cells to differentiate and self - organize into micron - scale cardiac tissue, including microchamberIn experiments to be published Tuesday, July 14, in the journal Nature Communications, the researchers used biochemical and biophysical cues to prompt stem cells to differentiate and self - organize into micron - scale cardiac tissue, including microchamberin the journal Nature Communications, the researchers used biochemical and biophysical cues to prompt stem cells to differentiate and self - organize into micron - scale cardiac tissue, including microchambers.

Their capacity to divide, differentiate and repopulate tissues, which typically declines with an organism's advancing age, resembled those of their stem - cell counterparts in younger animals.

Several years ago, one of the students in Verma's lab noticed that BRCA1 is very active in the neuroectoderm, a sliver of embryonic tissue containing neural stem cells that divide and differentiate into the brain's vast assortment of cell types and structures.

Stem cells can differentiate into any type of cell in the body and create new tissues to repair injuries.

The transplanted stem cells had differentiated into endothelial cells — which form the inner lining of a blood vessel, providing a barrier between blood and spinal cord tissue — and attached to capillaries in the spinal cord.

Induced pluripotent stem cells are a type of pluripotent stem cell that can be generated directly from adult cells; they have the ability to be differentiated into a variety of tissue types and, in this case, MSCs that can regenerate damaged lung tissue.

Using miR - 192 levels in the cells, the investigators were able to differentiate with very high certainty between normal and chronically inflamed pancreas tissue as well as between healthy pancreas tissue and pancreatic cancer.

The tumor cells were all undifferentiated and hence provided a homogeneous peripheral field, in contrast to the cells of the normal limb bud, which were destined to differentiate into many types of tissue.

«The region selective - state of these stem cells is entirely novel for laboratory - cultured stem cells and offers important insight into how human stem cells might be differentiated into derivatives that give rise to a wide range of tissues and organs,» says Jun Wu, a postdoctoral researcher in Izpisua Belmonte's lab and first author of the new paper.

In the paper, published May 6, 2015 in Nature, the scientists report using these new stem cells to develop the first reliable method for integrating human stem cells into nonviable mouse embryos in a laboratory dish in such a way that the human cells began to differentiate into early - stage tissueIn the paper, published May 6, 2015 in Nature, the scientists report using these new stem cells to develop the first reliable method for integrating human stem cells into nonviable mouse embryos in a laboratory dish in such a way that the human cells began to differentiate into early - stage tissuein Nature, the scientists report using these new stem cells to develop the first reliable method for integrating human stem cells into nonviable mouse embryos in a laboratory dish in such a way that the human cells began to differentiate into early - stage tissuein a laboratory dish in such a way that the human cells began to differentiate into early - stage tissuein such a way that the human cells began to differentiate into early - stage tissues.

The new iPS cells passed the standard tests for pluripotency: They formed tumors called teratomas when injected into immunocompromised mice, and they could differentiate into cells from the three main tissue types in the body, including neurons, muscle and gut epithelium.

Certain differentiated cells in breast tissue can spontaneously convert to a stem - cell - like state, according to Whitehead Institute researchers.

Recent evidence suggests the existence of progenitor cells in adult tissues that are capable of differentiating into vascular structures as well as into all hematopoietic cell lineages.

When fluid is pumped slowly across both sides of the membrane, replicating the flow of liquid along the inside and outside of intestinal tissue in the body, the seeded cells not only differentiate into the four types found in the small intestine, but form tissue that spontaneously folds, develops villi, secretes mucus and even supports microbes commonly found in the small intestine.

Unlike other cell types, stem cells are unspecialized cells uniquely capable of making copies of themselves (self - renewing), differentiating into specialized cell types, and helping to maintain some tissues in the human body.

In a developing embryo, stem cells can differentiate into all of the specialized embryonic tissues.

New planarian tissues and organs are created by neoblasts - adult stem cells that share certain characteristics with embryonic stem cells and can differentiate into essentially all the cells in adult animals.

The self - renewable capacity of these cells, their ability to differentiate into several tissue progenitors (neural, mesenchymal stem cells...), and the possibility to work with mutated cell lines define human stem cells as a good basis for screening compounds libraries in order to discover new potential drugs for monogenic diseases.

«A vast range of embryological and tissue progenitor or stem cells, along with differentiated cells, can now be isolated and studied in vitro.»

The more mature (that is, more differentiated) the cells are when transplanted, the less likely they are to over-grow (to generate too many RPE cells, which can lead to scar tissue) or to migrate away from their intended place in the body.

We differentiated our iPS cells as embryoid bodies (EB)(Figure 4A) in the presence of FBS to induce endodermal and mesodermal fates, and in the presence of retinoic acid to induce an ectodermal fate, and after ten days allowed them to adhere to tissue culture dishes.

In experiments published Tuesday, July 14 in the journal Nature Communications, the researchers used biochemical and biophysical cues to prompt stem cells to differentiate and self - organize into micron - scale cardiac tissue, including microchamberIn experiments published Tuesday, July 14 in the journal Nature Communications, the researchers used biochemical and biophysical cues to prompt stem cells to differentiate and self - organize into micron - scale cardiac tissue, including microchamberin the journal Nature Communications, the researchers used biochemical and biophysical cues to prompt stem cells to differentiate and self - organize into micron - scale cardiac tissue, including microchambers.

In a study using human muscle tissue, scientists in Children's Stem Cell Research Center - led by Johnny Huard, PhD, and Bruno Péault, PhD - isolated and characterized stem cells taken from blood vessels (known as myoendothelial cells) that are easily isolated using cell - sorting techniques, proliferate rapidly and can be differentiated in the laboratory into muscle, bone and cartilage cellIn a study using human muscle tissue, scientists in Children's Stem Cell Research Center - led by Johnny Huard, PhD, and Bruno Péault, PhD - isolated and characterized stem cells taken from blood vessels (known as myoendothelial cells) that are easily isolated using cell - sorting techniques, proliferate rapidly and can be differentiated in the laboratory into muscle, bone and cartilage cellin Children's Stem Cell Research Center - led by Johnny Huard, PhD, and Bruno Péault, PhD - isolated and characterized stem cells taken from blood vessels (known as myoendothelial cells) that are easily isolated using cell - sorting techniques, proliferate rapidly and can be differentiated in the laboratory into muscle, bone and cartilage ceCell Research Center - led by Johnny Huard, PhD, and Bruno Péault, PhD - isolated and characterized stem cells taken from blood vessels (known as myoendothelial cells) that are easily isolated using cell - sorting techniques, proliferate rapidly and can be differentiated in the laboratory into muscle, bone and cartilage cecell - sorting techniques, proliferate rapidly and can be differentiated in the laboratory into muscle, bone and cartilage cellin the laboratory into muscle, bone and cartilage cells.

InvivoSciences makes engineered heart tissues from mouse embryonic stem cells and stem cells from differentiated adult tissues in humans, such as fat and skin.

In a developing embryo, stem cells can differentiate into all the specialized cells, but also maintain the normal turnover of regenerative organs, such as blood, skin, or intestinal tissues.

Adipose tissue contains differentiated cells called adipocytes that are specialized in storing fat.

To explore the differentiation markers for detecting germ cells differentiated from ES cells, the expression of various germ cell marker genes was examined in tissues and ES cells of the cynomolgus monkey (Macaca fascicularis).

In a study published recently in Cell, researchers at the University of São Paulo's Ribeirão Preto Medical School (FMRP - USP) in Brazil and collaborators in several other countries describe a method that objectively measures the degree of similarity between tumor samples and pluripotent stem cells (cells that can differentiate into nearly any type of tissue in the bodyIn a study published recently in Cell, researchers at the University of São Paulo's Ribeirão Preto Medical School (FMRP - USP) in Brazil and collaborators in several other countries describe a method that objectively measures the degree of similarity between tumor samples and pluripotent stem cells (cells that can differentiate into nearly any type of tissue in the bodyin Cell, researchers at the University of São Paulo's Ribeirão Preto Medical School (FMRP - USP) in Brazil and collaborators in several other countries describe a method that objectively measures the degree of similarity between tumor samples and pluripotent stem cells (cells that can differentiate into nearly any type of tissue in the bodyin Brazil and collaborators in several other countries describe a method that objectively measures the degree of similarity between tumor samples and pluripotent stem cells (cells that can differentiate into nearly any type of tissue in the bodyin several other countries describe a method that objectively measures the degree of similarity between tumor samples and pluripotent stem cells (cells that can differentiate into nearly any type of tissue in the bodyin the body).

As cells divide and differentiate, changes in transcriptional profile occur, leading to considerable phenotypical diversities forming different subpopulation of cells and tissues in living organisms.

«We take human stem cells and differentiate them into cardiomyocytes and build 3D tissues out of them,» said Tracy Hookway, a postdoctoral scholar in McDevitt's laboratory.

During wound healing differentiated Gata6 (+) cells migrate from the SD into the interfollicular epidermis and dedifferentiate, acquiring the ability to undergo long - term self - renewal and differentiate into a much wider range of epidermal lineages than in undamaged tissue.

I had a hunch based on this work that microRNA expression would be different in breast cancer stem cells than in more differentiated tumor cells or normal tissue and that it would change as the stem cells differentiated to form a tumor.

Histopathology (microscopic examination of tissues) is important, because in the urine of atleast 30 % of dogs, neoplastic cells can not be differentiated from reactive epithelial cells associated with inflammation.