Not exact matches
«Scientists have thought that
fibroblasts are terminally
differentiated, meaning they can't adopt the fate of other kinds of
cells; but our study suggests this may not be entirely true,» said Eric Ubil, PhD, a postdoctoral fellow at UNC and first author of the Nature study.
Fibroblasts are a dynamic
cell type that achieve selective
differentiated states to mediate acute wound healing and long - term tissue remodeling with scarring.
They have already shown that they can transform human
fibroblast cells into pluripotent stem
cells, and now plan to start working on delivering the proteins needed to
differentiate stem
cells into specialized tissues.
(C) When iPS
cells were cultured in the absence of the HFF
cells, various
differentiated cells could be observed, such as definitive endoderm - like
cells (a) and (b),
fibroblast - like
cells (c), cardiomyocytes (d), epidermis - like
cells (e) and neural rosettes (f).
We hypothesize that SSEA3 expression is either identifying another less
differentiated and / or tissue specific stem
cell like population that is retrieved with the donor skin biopsy or that with culture, a subpopulation of
fibroblasts may acquire the ability to express SSEA3.
The endothelial
cells became vessels, recruited
fibroblasts and caused them to
differentiate into smooth muscle
cells.