Not exact matches
His lab
differentiates iPSCs from autistic patients into neurons and
glial cells, which they suspect may be releasing cytokines at levels higher than normal in autistic patients.
They also applied it to human brain tissue collected by the Genotype - Tissue Expression (GTEx) Project, finding that they could a) identify expression signatures unique to neurons,
glial cells, and other
cell types in the brain (including rare types), and b)
differentiate between closely related
cell subtypes.
Progenitors of the central retina are the first to leave the
cell cycle and
differentiate into the six neuronal and one
glial cell class of the mature retina.
In culture, neural stem
cells (NSCs) can readily
differentiate into neuronal and
glial subtypes, but their ability to
differentiate into region - specific neuronal
cell types is limited.
Instead of developing into motor neurons like they usually would, most
cells instead
differentiated into a type of
glial cell called a floor plate
cell.
Amiodarone HCL was found to be selectively toxic to NSCs but not to
differentiated neurons or
glial cells.
Immunocytochemical staining for Ki67 (
cell proliferation marker), Sox2 (neural stem
cell marker), Olig2 (progenitor
cell marker), and GFAP (
glial fibrillary acidic protein, a marker for
differentiated astrocytes) captured by confocal microscopy imaging.