Sentences with phrase «difficult side effects»

Current treatment strategies (most often long - term steroid use) are plagued by difficult side effects and fail to target an underlying source of the disease.

Not exact matches

These risks and uncertainties include, among others: the unfavorable outcome of litigation, including so - called «Paragraph IV» litigation and other patent litigation, related to any of our products or products using our proprietary technologies, which may lead to competition from generic drug manufacturers; data from clinical trials may be interpreted by the FDA in different ways than we interpret it; the FDA may not agree with our regulatory approval strategies or components of our filings for our products, including our clinical trial designs, conduct and methodologies and, for ALKS 5461, evidence of efficacy and adequacy of bridging to buprenorphine; clinical development activities may not be completed on time or at all; the results of our clinical development activities may not be positive, or predictive of real - world results or of results in subsequent clinical trials; regulatory submissions may not occur or be submitted in a timely manner; the company and its licensees may not be able to continue to successfully commercialize their products; there may be a reduction in payment rate or reimbursement for the company's products or an increase in the company's financial obligations to governmental payers; the FDA or regulatory authorities outside the U.S. may make adverse decisions regarding the company's products; the company's products may prove difficult to manufacture, be precluded from commercialization by the proprietary rights of third parties, or have unintended side effects, adverse reactions or incidents of misuse; and those risks and uncertainties described under the heading «Risk Factors» in the company's most recent Annual Report on Form 10 - K and in subsequent filings made by the company with the U.S. Securities and Exchange Commission («SEC»), which are available on the SEC's website at www.sec.gov.

To argue by inference from effect to Cause, from the passive object to the active Subject of change, from transitory, contingent being to a Being who is necessary and eternal, from nature's striving after perfection to a Perfection which is ultimate, from the order observable in creation to a creative Mind - all that (I shall be told) is to approach the great Riddle from one side, and that the most difficult.

Exhaustion is listed as a potential side effect of castor oil, which can make labor a little more difficult if you're already tired.

Reform is a more difficult issue of deciding what it is one wants to support — what kind of public interests public support should serve, what kinds of public goods one wants delivered — and developing forms of direct and indirect support that effectively encourage that without too many malign side effects.

«Since it exhibits various other functions in cell metabolism, potential side effects are still difficult to assess.»

«Psychiatry has long struggled with the fact that, while lithium is highly effective for treating bipolar disorder, the narrow therapeutic window and side effect profile often makes lithium both difficult and sometimes dangerous to work with clinically,» said Todd Gould, MD, of the Department of Psychiatry at the University of Maryland, an expert in the mechanisms of lithium and the neurobiology of bipolar disorder.

However, developing RNAi therapies has proven challenging because it is difficult to deliver large quantities of siRNA to the right location without causing side effects in other tissues or organs.

However, these strategies have had only limited success, because it is difficult to get all of the vaccine to the lymph nodes without some escaping to the rest of the body, which can cause unwanted side effects.

That's still difficult for schizophrenia itself, let alone side effects of schizophrenia drugs.

«Yet many cancer survivors are living with difficult and persistent side effects of these treatments, which can be incapacitating.

It's challenging to find alternatives to opioids because it's so difficult to craft painkillers without side effects.

The therapy has led to remission rates as high as 90 % in children and young adults with B - cell acute lymphoblastic leukemia (ALL); however, the side - effects can be extreme and difficult to manage.

In contrast, Disney noted, a typical cancer therapeutic targets and kills cells indiscriminately, often leading to side effects that can make these drugs difficult for patients to tolerate.

We have known for a while that microRNAs are important in cancer, but their diversity of roles has meant it's been difficult to target them with drugs without causing toxic side - effects.

However, delivering growth factors to the brain has proved difficult and risky for patients with significant side effects observed [120], such as sprouting of sensory and sympathetic neurons [121], and neuropathic pain [120].

Immunotherapy side effects can be very difficult to spot because they can cause symptoms that are associated with common ailments and infections.

The portfolio of available antibiotics for treating antibiotic resistant bacterial infections is very limited and comprises molecules inducing severe side effects and / or difficult to administrate like aminoglycosides and vancomycin that require parenteral injection.

But despite their good prognosis, many patients» powerful gut responses to their diagnosis (and the overall threat of cancer) drive their preferences for the most aggressive treatment strategies — overtreatment that could have incumbent side effects, additional risks or more difficult recovery.

GSK3β, the first neighbour of β - catenin is a central, highly multi-functional protein known as a key protein difficult to inhibit without causing side effects and toxicity.41 In glioblastoma and NSCLC cancer, previous studies found that the decreased level of FRAT1 influences the GSK3β activity to phosphorylate β - catenin and by that, inhibit the WNT pathway.39, 40 The role of FRAT1 in colon cancer is less known but based on its function in other cancer types and its special influencing position in colon cancer signalling, we point out its relevance as a potential target in colon cancer therapy (Fig. 3d).

Side effects of quitting Eliminating fast food can be as difficult as giving up smoking, as your brain becomes addicted to the ingredients in the food.

This method destroys most (but not all) of the anti-nutrients but has the unhappy side effect of so denaturing the proteins that they become very difficult to digest and much reduced in effectiveness.12 The phytate content remains in soy milk to block the uptake of essential minerals.

This process removes most — but not all — of the trypsin inhibitors, but has the unfortunate side effect of over-denaturing the other proteins in soy, particularly lysine, rendering them difficult to digest and possibly toxic.

This serious side effect of weight loss surgery is difficult to fix.

Initiation can be difficult (carbohydrate withdrawal) Socially challenging (can be hard to eat out) There may be side effects, depending on food choices Cheating once can set you back a few days or more Some versions allow processed / artificial foods Some people need to also limit calories to lose weight

The side effects were so bad that even though he completed the race and did relatively well, he concluded that trying to stay in ketosis all the time, despite the performance benefits, was just too difficult and inconvenient.

Many Westerners however find squatting is difficult due to lack of strength and range of motion in the hips, and lack of extensibility in the calves, a side effect of sitting in chairs for lengthy periods of the day and wearing heeled shoes.

Though it would be difficult to consume this much ginger without taking a supplement, this would still be preferable to a pharmaceutical med, many of which have unwanted side effects.

It doesn't come with a lot of side effects, and the results are difficult to ignore.

A 2015 Study examined a group of individuals that were considered «statin intolerant», meaning that they suffered from statin side effects, particularly muscle pains, that made it difficult or unbearable to continue taking the drug.

The fact that it might eliminate your need for medication, make you feel — and be — younger, drastically reduce your risk for chronic disease, fix your brain, and other benefits too numerous to list here — and does all this without side - effects — makes it a difficult sell.

Beyond making you feel lousy, dehydration can have serious side effects on your blood volume and tissues, making it difficult for your body to detoxify itself.

However, the diet's strictness, unpalatability and side effects can make it difficult to adhere to.

Of course coconut oil is a natural food, with virtually no risk or side effects, and funding for research on a natural food is difficult to come by when no product can be patented as a result of the research, such as lucrative pharmaceutical drugs.

You should know that being overweight can worsen the side effects of low hormonal levels and make it difficult for your body to produce enough hormones.

The main drawback with the ketogenic diet was difficult tolerability and high dropout rates — given the extremely positive results and the severe side effects common with antiepilepsy medication, the development of an easier - to - follow ketogenic diet would be a worthwhile goal.5

There are treatments for sickle cell, such as some cancer drugs, Buchanan pointed out, but they can be difficult to manage and have side effects.

«It would be a difficult clinical decision whether or not to treat these symptoms of menopause with hormone replacement therapy, as these come with their own significant side effects and risks,» Bond said.

It's a difficult balance to establish a healthy sex life between chronic pain, unexpected bleeding, medication side effects, and hormone imbalances.

Anna Karenina becomes a case of director Wright favoring style over substance, with the unfortunate side effect that the style makes it very difficult to maintain a sense of place and time.

The more difficult success factors in just about any field come from more human skills such as collaboration, critical thinking, and creativity, all of which are developed as a side effect of gameplay in MMORPG's such as World of Warcraft.

Difficult and time consuming but I see it as a winning formula, but then I noticed a strange side - effect.

Even if this were true, it's difficult to know whether the rising stock market actually affects economic growth or if it is one of the side effects of a healthy and productive business environment.

Many inexperienced dog owners find it very difficult to judge just how sensitive their dog is, and how much force to use without adverse side effects.

Thus arises a very difficult part of this diagnosis: deciding whether extending the animal's life for a short time is worth the expense and side effects.

In pets, it is difficult to tell if they may experience this side effect.

If any of the following side effects occur, contact your veterinarian immediately: hives, difficult breathing, swelling (lips, tongue or face) May cause mouth irritation if it hasn't been mixed well with moistened food and allowed to stand High doses may cause nausea, cramping, diarrhea or vomiting If these symptoms persist or you notice anything else unusual, contact your veterinarian Can this drug be given with other drugs?

It is a difficult operation and side effects and failures are not uncommon.

Our modelling indicates strongly that a tax at this low level will have no effect upon coal - fired generation and, given the relatively low price elasticity of demand for electricity at the retail level (probably because electricity has been so cheap in Australia), the demand side effect would be negligible and difficult to spot given the srong secular growth in demand.

This serious side effect can be difficult to treat and may cause disfigurement.