Sentences with phrase «difficult time in the world»

Not exact matches

These risks and uncertainties include, among others: the unfavorable outcome of litigation, including so - called «Paragraph IV» litigation and other patent litigation, related to any of our products or products using our proprietary technologies, which may lead to competition from generic drug manufacturers; data from clinical trials may be interpreted by the FDA in different ways than we interpret it; the FDA may not agree with our regulatory approval strategies or components of our filings for our products, including our clinical trial designs, conduct and methodologies and, for ALKS 5461, evidence of efficacy and adequacy of bridging to buprenorphine; clinical development activities may not be completed on time or at all; the results of our clinical development activities may not be positive, or predictive of real - world results or of results in subsequent clinical trials; regulatory submissions may not occur or be submitted in a timely manner; the company and its licensees may not be able to continue to successfully commercialize their products; there may be a reduction in payment rate or reimbursement for the company's products or an increase in the company's financial obligations to governmental payers; the FDA or regulatory authorities outside the U.S. may make adverse decisions regarding the company's products; the company's products may prove difficult to manufacture, be precluded from commercialization by the proprietary rights of third parties, or have unintended side effects, adverse reactions or incidents of misuse; and those risks and uncertainties described under the heading «Risk Factors» in the company's most recent Annual Report on Form 10 - K and in subsequent filings made by the company with the U.S. Securities and Exchange Commission («SEC»), which are available on the SEC's website at www.sec.gov.

«I love Uber more than anything in the world and at this difficult moment in my personal life I have accepted the investors request to step aside so that Uber can go back to building rather than be distracted with another fight,» Kalanick said in a statement to the Times.

This is the point of view of an elitist from the first world with total disregard to the circu.mstances of lots and lots of people in much more difficult circ.umstances in the rest of the world who have neither the leisure time, education, literacy, or resources to «study» any religion, let alone choose yours to study.

It is difficult to see how, if God's relationship to the world is «wholly other» than the relation of creative spirit to its actual working in time (chronos), we can avoid discounting the Christian significance of creative effort, patient workmanship, and that careful assessment of conditions and consequences which make up so large a part of the wisdom of life.

The public, then, has a difficult time evaluating a major publication such as U. S. News & World Report (December 22, 1997) when it makes the announcement — for which no source is given — that charitable activity was «up 9.5 percent in two years,» a figure that corresponds to AAFRC figures for that time period.

It is difficult to imagine this tenet forming part of a sermon; I can not recall a preacher ever saying, «This text tells us that Jesus expected the end of the world in his own time; he was wrong of course, but let's see what we can make of the text anyway.

In a world marked by the effects of original sin, and certainly in a post-Christian, secular culture, one can agree that human beings have a very difficult time grasping metaphysical truths or principles of the natural laIn a world marked by the effects of original sin, and certainly in a post-Christian, secular culture, one can agree that human beings have a very difficult time grasping metaphysical truths or principles of the natural lain a post-Christian, secular culture, one can agree that human beings have a very difficult time grasping metaphysical truths or principles of the natural law.

... wow, lot's of mis - statements here by people speculating about the Bible and Jesus, including those of you who think the books of the Bible were written a few hundred years ago (Moses penned it around 1400BC)... the Bible is a collection of the most investigated writings of all time, so there is a tremendous amount of credible archeological and scientific material in this world available for review rooted in verifiable investigations... my response, read the Bible, do your own investigation, determine the Truth for yourself... hopefully, anne rice's denouncement of faith in the God of the Bible (it's difficult for me to believe she ever had Saving Faith in the first place) will bring some readers to investigate and find the Truth... God will call the Elect, not one more, not one less...

For anyone going through difficult times, you are going to be better served by people in the secular world or people operating apart from their Church.

I understand that thinking for yourself and seeing the logic is difficult after the brainwashing abuse your horrible parents did to you but it's time to grow up and think in the real world little one.

In this context it is difficult not to recall the observation of Eddington, made a half - century ago (NPW 47 - 58) that in Minkowski's time - space the past is separated from the future even more effectively than in the world of Newton: instead of an instantaneous three - dimensional cross-section, it is a four - dimensional region of «Elsewhere» which separates the causal past from the causal futurIn this context it is difficult not to recall the observation of Eddington, made a half - century ago (NPW 47 - 58) that in Minkowski's time - space the past is separated from the future even more effectively than in the world of Newton: instead of an instantaneous three - dimensional cross-section, it is a four - dimensional region of «Elsewhere» which separates the causal past from the causal futurin Minkowski's time - space the past is separated from the future even more effectively than in the world of Newton: instead of an instantaneous three - dimensional cross-section, it is a four - dimensional region of «Elsewhere» which separates the causal past from the causal futurin the world of Newton: instead of an instantaneous three - dimensional cross-section, it is a four - dimensional region of «Elsewhere» which separates the causal past from the causal future.

This was my first experience at making these buns, and I honestly thought It would be the most difficult thing in the entire world, and I would have the hardest time convincing you guys to try it.

So much of this type of thing is happening in our food system at all times, where we are told we are getting A, while actually getting B. Of course, in today's world, it's difficult to be in the know about everything, and we have to pick our battles, but it's always good to have some of those veils lifted.

All of my family left Lebanon around this time, since politically it had become a difficult world to live in.

I always have a difficult time on my birthday as I find it a reminder of how alone I am in the world.

Plus, being able to headline a much smaller show that largely occurs at the same venue every time isn't even remotely as difficult as headlining in huge arenas around the country / world.

we have waited a long time for this club to truly step up, which is a difficult ask... to do so properly they will need to overextend themselves and get well outside the comfort zone they have become accustomed to... at the very least they owe their fans, most of whom supported this franchise for at least the first 8 years of this 10 year plan, one real shot at the «promised» land... remember phase one was build and save, phase two was the fire sale of all our top players, phase three was supposed to be our metamorphosis, when we were literally told how we could compete with any club in the world and phase four appears to be rinse and repeat, under the guise that we just can't seem to find any players that are better than our current lot (can you even imagine the state of world soccer if that were truly the case)... it's time for you Mr. Kroenke and Mr. Wenger to ask not what the fans can do for you, but what you two can do to make things right again for the fans... if you can't do this earnestly and honestly, simply move on before the only thing left in the cupboard are bitter memories and what could have beans?

This is an incredibly difficult question to answer for a variety of reasons, most importantly because over the years our once vaunted «beautiful» style of play has become a shadow of it's former self, only to be replaced by a less than stellar «plug and play» mentality where players play out of position and adjustments / substitutions are rarely forthcoming before the 75th minute... if you look at our current players, very few would make sense in the traditional Wengerian system... at present, we don't have the personnel to move the ball quickly from deep - lying position, efficient one touch midfielders that can make the necessary through balls or the disciplined and pacey forwards to stretch defences into wide positions, without the aid of the backs coming up into the final 3rd, so that we can attack the defensive lanes in the same clinical fashion we did years ago... on this current squad, we have only 1 central defender on staf, Mustafi, who seems to have any prowess in the offensive zone or who can even pass two zones through so that we can advance play quickly out of our own end (I have seen some inklings that suggest Holding might have some offensive qualities but too early to tell)... unfortunately Mustafi has a tendency to get himself in trouble when he gets overly aggressive on the ball... from our backs out wide, we've seen pace from the likes of Bellerin and Gibbs and the spirited albeit offensively stunted play of Monreal, but none of these players possess the skill - set required in the offensive zone for the new Wenger scheme which requires deft touches, timely runs to the baseline and consistent crossing, especially when Giroud was playing and his ratio of scored goals per clear chances was relatively low (better last year though)... obviously I like Bellerin's future prospects, as you can't teach pace, but I do worry that he regressed last season, which was obvious to Wenger because there was no way he would have used Ox as the right side wing - back so often knowing that Barcelona could come calling in the off - season, if he thought otherwise... as for our midfielders, not a single one, minus the more confident Xhaka I watched played for the Swiss national team a couple years ago, who truly makes sense under the traditional Wenger model... Ramsey holds onto the ball too long, gives the ball away cheaply far too often and abandons his defensive responsibilities on a regular basis (doesn't score enough recently to justify): that being said, I've always thought he does possess a little something special, unfortunately he thinks so too... Xhaka is a little too slow to ever boss the midfield and he tends to telegraph his one true strength, his long ball play: although I must admit he did get a bit better during some points in the latter part of last season... it always made me wonder why whenever he played with Coq Wenger always seemed to play Francis in a more advanced role on the pitch... as for Coq, he is way too reckless at the wrong times and has exhibited little offensive prowess yet finds himself in and around the box far too often... let's face it Wenger was ready to throw him in the trash heap when injuries forced him to use Francis and then he had the nerve to act like this was all part of a bigger Wenger constructed plan... he like Ramsey, Xhaka and Elneny don't offer the skills necessary to satisfy the quick transitory nature of our old offensive scheme or the stout defensive mindset needed to protect the defensive zone so that our offensive players can remain aggressive in the final third... on the front end, we have Ozil, a player of immense skill but stunted by his physical demeanor that tends to offend, the fact that he's been played out of position far too many times since arriving and that the players in front of him, minus Sanchez, make little to no sense considering what he has to offer (especially Giroud); just think about the quick counter-attack offence in Real or the space and protection he receives in the German National team's midfield, where teams couldn't afford to focus too heavily on one individual... this player was a passing «specialist» long before he arrived in North London, so only an arrogant or ignorant individual would try to reinvent the wheel and / or not surround such a talent with the necessary components... in regards to Ox, Walcott and Welbeck, although they all possess serious talents I see them in large part as headless chickens who are on the injury table too much, lack the necessary first - touch and / or lack the finishing flair to warrant their inclusion in a regular starting eleven; I would say that, of the 3, Ox showed the most upside once we went to a back 3, but even he became a bit too consumed by his pending contract talks before the season ended and that concerned me a bit... if I had to choose one of those 3 players to stay on it would be Ox due to his potential as a plausible alternative to Bellerin in that wing - back position should we continue to use that formation... in Sanchez, we get one of the most committed skill players we've seen on this squad for some years but that could all change soon, if it hasn't already of course... strangely enough, even he doesn't make sense given the constructs of the original Wenger offensive model because he holds onto the ball too long and he will give the ball up a little too often in the offensive zone... a fact that is largely forgotten due to his infectious energy and the fact that the numbers he has achieved seem to justify the means... finally, and in many ways most crucially, Giroud, there is nothing about this team or the offensive system that Wenger has traditionally employed that would even suggest such a player would make sense as a starter... too slow, too inefficient and way too easily dispossessed... once again, I think he has some special skills and, at times, has showed some world - class qualities but he's lack of mobility is an albatross around the necks of our offence... so when you ask who would be our best starting 11, I don't have a clue because of the 5 or 6 players that truly deserve a place in this side, 1 just arrived, 3 aren't under contract beyond 2018 and the other was just sold to Juve... man, this is theraputic because following this team is like an addiction to heroin without the benefits

Joining a club of arsenal s stature has its ups and downs.There is a requirement of how our players should perform when on the pitch.The following is a list of players who were wrong to choose arsenal.Aaron ramsey - Even though he is the most favoured of all players at the club now.I cant help but think how it would have gone for Him if he decided to search for other greener pastures.He was a clear talented footballer during his time at cardiff but he hasnt been raised with the discipline at arsenal.You can always see ramseys all round strengths but sadly Its not helping him or the club with his foward moving pleasurr.He is so Over used and its sometimes difficult for him to get used to the rythm of the game.With time you realise he gets low ib confidence and his engine gets wasted.He needed somebody who would have managed him properly and with care and that person is certainpy not wenger.You would have been better off at Manu mate.Calum chambers - Came us a very talented player from southampton with raw talent.He was very good at first but wenger found a way to reduce his level of confidence.His inexperience was left exposed and wenger did nt do anything to resolve that problem and instead He looked for other talented players.Alex oxlade chamberlain - Another very talented player who needed only his skilled sharpened and his character modelled.That and he was ready to become a world beater.But wenger decided to let him run and run like a headless chicken causing him to be often injured and damaging his confidence.Who knows what would have happened to him gad he decided to look for more greener pasture.He is surely a much better player than this.Theo walcott - Another player who was tipped to have a very bright future.He had it in him.But all he needed was an appropriate manager who would nurture him with discipline and help him with his talent.But on Coming to arsenal he was given Much more responsiblities putting more weight on his shoulders on top of that another player who was recklessly managed with his talent and never coming off age because his character wasnt properly shaped.Mesut ozil - Al right i agree he perfoms well just recently.But imagine all the legendary players he was often compared to during his time at real madrid.On coming to arsenal he found no rotation often overused, suffered many injuries and his confidence dwindled.It is pretty clear arsene does not take any responsibility for players.And when at arsenal you have to be your own manager.You need not rely on your manager otherwise you might continue being the same player for the next many years.That is why each and every player are what they are because of their own efforts and wenger had nothing to do with it.Van persie was the same player for over 7 years untill he himself decided to change.Wenger only organises and prepares tge team while the rest is in your court.It is not what so many people make it out to be.Thats why we need to pressure wenger more than our own players.They are their own self managers and wenger needs to take that responsibility

Even with the unlimited funds, it appears Sheikh Mansour bin Zayed Al Nahyan will have a difficult time convincing the best players in the world that Manchester City is the right club for them.

(«It is difficult,» says Kada, «because in 1996, when Hicham was 21, he had the world's best time in this event.»)

Although it will be incredibly difficult to ever match his contributions on the pitch, it's vitally important for a former club legend, like Henry, to publicly address his concerns regarding the direction of this club... regardless of those who still feel that Henry has some sort of agenda due to the backlash he received following earlier comments he made on air regarding Arsenal, he has an intimate understanding of the game, he knows the fans are being hosed and he feels some sense of obligation, both professionally and personally, to tell it like he sees it... much like I've continually expressed over the last couple months, this team isn't evolving under this current ownership / management team... instead we are currently experiencing a «stagnant» phase in our club's storied history... a fact that can't be hidden by simply changing the formation or bringing in one or two individuals... this team needs fundamental change in the way it conducts business both on and off the pitch or it will continue to slowly devolve into a second tier club... regardless of the euphoria surrounding our escape act on Friday evening, as it stands, this club is more likely to be fighting for a Europa League spot for the foreseeable future than a top 4 finish... we can't hope for the failures of others to secure our place in the top 4, we need to be the manufacturers of our own success by doing whatever is necessary to evolve as an organization... if Wenger, Gazidis and Kroenke can't take the necessary steps following the debacle they manufactured last season, their removal is imperative for our future success... unfortunately, I strongly believe that either they don't know how to proceed in the present economic climate or they are unwilling to do whatever it takes to turn this ship around... just look at the current state of our squad, none of our world class players are under contract beyond this season, we have a ridiculous wage bill considering the results, we can't sell our deadwood because we've mismanaged our personnel decisions and contractual obligations, we haven't properly cultivated our younger talent and we might have become one of the worst clubs ever when it comes to way we handle our transfer business, which under Dein was one of our greatest assets... it's time to get things right!!!

For people living outside of Europe, the Champions League draw this afternoon was kinda difficult to follow live because of the time zones, world clock, Greenwich Meridian thingy stuff, so here's a small update about the team Roma will face in the CL semi-final.

Experiencing such difficult time after his biting incident in last World Cup, Luis Suarez has come a long way in showcasing his maturity as he has been doing well with Barcelona and Uruguay.

The Costa Rica international has had a difficult time with injuries over the last two years, missing the 2014 World Cup in Brazil after breaking his leg in January that year.

But while coming home to a wife was beneficial to veterans returning to civilian life after serving in Vietnam or the Korean War / World War II era, or in periods between, being married isn't helping post-9 / 11 veterans readjust; in fact, «post-9 / 11 veterans who were married while they served had a significantly more difficult time readjusting than did married veterans of past eras or single people regardless of when they served.

When it comes to sleep, the biggest challenge for school - age children and their parents is the demands on a child's time that will make early bedtime routines difficult to manage, especially in today's 24 - 7 wired and fast - paced world.

Having Denise here caring for my babies as well as helping me through such a difficult time made all the difference in the world.

I have never been more tired, hungry (pregnancy hunger has NOTHING on nursing hunger for this mama), or busy — finding time for myself is literally the most difficult thing in the world these days.

The either - or position is a difficult one in a world where many parents feel it is possible to have both one - on - one time and screen time in their baby's life.

Self - discipline with time management can be a difficult skill to teach in today's world.

Since many new moms have a difficult time getting out, and since I like to see what is actually happening I am going to be joining the new Google Helpouts team in providing services to women all over the world!

However, it is difficult to remember a time when foreign policy played such a small role in a domestic election, particularly at a time when the world is such an uncertain place and globalization is making our foreign relations with each other ever more important.

«Manhattan is desirable to the world but it took real people in difficult times to get the civic fabric in place so that we have a place where the rest of the world wants to be.»

Out in the real world, meanwhile, The Labour leaders of British cities are exploring the theory and practice of centre - left politics in unspeakably difficult times.

«During this campaign my case has been based on three things: first, the need for strong, proven leadership to steer us through what will be difficult and uncertain economic and political times, the need, of course, to negotiate the best deal for Britain in leaving the EU and to forge a new role for ourselves in the world.

«We want this to be one of the most successful countries in the world in 20, 30, 40 years» time; there's a pretty difficult question that we have to answer which is essentially: are we going to be a country that is prepared to work hard in the way that Asian economies are prepared to work hard, in the way that Americans are prepared to work hard.

To paraphrase George Osborne (and Fraser Nelson in the News of the World) the Tory leadership did not fix the party's finances during the good economic times and are now facing very difficult decisions as a consequence.

The images chosen elicit memories of a tense and difficult time in the City's history but as you know, New York is the safest big city in the world.

Without another example like it in the solar system, astronomers have had a difficult time describing how such a wacky world formed.

We start with the fuzzy world of quantum geometry, where it is even difficult to say what is time and what is space, yet the phenomena occurring in our cosmological model still look as if everything was happening in ordinary spacetime!

Even here on Earth, with all the time and resources in the world, confirming the existence and nature of ancient life (~ 4 billion years old) has proven difficult — and it is unlikely to be any easier with Mars.

It deliberately poisons a portion of the natural world for an endless stretch of time and in doing so it not only leaves future generations with thousands of tons of the most dangerous rubbish imaginable on their hands but makes it as difficult as the state of our technology permits for them to deal with it.

Optimists tend to be upbeat and look on the bright side of things, frequently viewing the world as a positive place, determining ways to affect the outcome of even difficult situations, and finding meaning in darker times.

However, if your schedule makes regular workouts difficult and you spend most of your time sitting in front of a computer, these quick exercises could make a world of difference to your current and future wellbeing!

Relaxation: In our plugged - in, information - overload world, you may find it difficult at first to spend some time in the sauna free from your phone, family, or job, but this actually a boon to your healtIn our plugged - in, information - overload world, you may find it difficult at first to spend some time in the sauna free from your phone, family, or job, but this actually a boon to your healtin, information - overload world, you may find it difficult at first to spend some time in the sauna free from your phone, family, or job, but this actually a boon to your healtin the sauna free from your phone, family, or job, but this actually a boon to your health.

You have to start with something, else you end up keeping your creative world only for yourself and it is too easy and too difficult in the same time to live in your «hutte», you need to challenge your creations in reality, at least to give it a try.

In the busy world we all live in it can be difficult for women and men in Croydon to try and have the time to go out and meet peoplIn the busy world we all live in it can be difficult for women and men in Croydon to try and have the time to go out and meet peoplin it can be difficult for women and men in Croydon to try and have the time to go out and meet peoplin Croydon to try and have the time to go out and meet people.

With the rise of online dating, many singles who have a difficult time dating are making the effort in joining the online dating world.

Dear friends, In today's world it is often very difficult to meet people with similar interests, especially for those that have little time for dating and may be looking for specific things like personality,...