Sentences with word «dimeric»

Comparison of loop conformation of Ab - R - ATA and artificially produced ATA -117-Rd11: Superimposed dimeric structures of Ab - R - ATA and ATA -117-Rd11.

Thus, the identification of dimeric ligands would be a promising approach for the development of effective CXCR4 antagonists [12].

And, indeed, previous research has shown that receptor tyrosine kinases, e.g. insulin receptors, and cytokine receptors, e.g. growth hormone receptors, exist in dimeric form even in the absence of ligands.

In Class II engagement, Sox9 binds to multiple active enhancer elements through sub-optimal, low - affinity Sox dimeric motifs (DNA sequences), resulting in a high level of transcription of cartilage - related genes.

They found that 0.05 % of the variants were monomers that could work as well as the original dimeric CM.

Prof. Maruyama's «rotation model» provides an explanation of the ligand activation mechanism of dimeric receptors.

Inhibits the activity of dimeric NF - kappa - B / REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals.

Previously, dimeric analogues of FC131 were used as starting points to evaluate the optimal distance between the monomeric units [81].

Design, synthesis, and functionalization of dimeric peptides targeting chemokine receptor CXCR4.

Type II parasites used in preliminary studies were either Prugniaud expressing tandem dimeric tomato red fluorescent protein and OVA peptide [36](dose: 2500 parasites) or ME49 expressing luciferase [37](dose: 300 parasites).

Bis -(3», 5»)- cyclic dimeric adenosine monophosphate: strong Th1 / Th2 / Th17 promoting mucosal adjuvant.Vaccine.

We evolved a variant of the wild type dimeric FP eqFP578 [13] denoted eqFP615 (Evrogen JSC) into the FP Amrose variants with 590 — 594 nm / 639 — 644 nm Ex / Em peaks as purified protein.

Appropriate modification of the salphen ligand allows an easy modular design of flexibly linked dimeric salphen species and their complexes, which can act as bifunctional catalysts.

In order to reveal how dimerization improves PTEN's ability to thwart tumor development, researchers needed to establish the protein's dimeric structure.

HMAb 2D22 binds across viral envelope (E) proteins in the dimeric structure, which probably blocks the E protein reorganization required for virus fusion.

While its general architecture resembles scramblases of the same family, there are distinct differences in the pore region located in each subunit of the dimeric protein.

Monomeric ribonuclease A has very low activity toward typically double - stranded RNA's; the dimeric form of ribonuclease A obtained by cross linking the enzyme by dimethyl suberimidate has more than 78 times the activity of the monomer toward polyadenylate · polyuridylate and 440 times the activity of the monomer toward the double - stranded RNA of a virus from Penicillium chrysogenum.

By evaluating the activity of the molecular structure of cinnamtannin B - 1 by structural unit, this group revealed that a dimeric structure in which two catechin are bound at a specific site is important for promoting the mobilization of MSC.

The ability to determine protein stoichiometry and monitor changes in the balance between monomeric, dimeric and multi-meric proteins can allow scientists to see the differences between a properly functioning cell and a diseased cell.

Recently, researchers led by Pier Paolo Pandolfi at Harvard Medical School found that PTEN's tumor suppressing activity becomes elevated when two copies of the protein bind together, forming a dimeric protein.

An improved binding affinity was detected after the presence of long spacers, with lengths from 20 to 80Å, in a dimeric ligand suggesting two different binding sites [11, 82].

On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.

This was also confirmed by the structural elucidation of the pharmacophoric groups in the dimers and with a comparison of the dimeric scaffold to the oligomer polyphemusin II structure that was used for the design of the first cyclic - pentapeptide derivatives and by recent molecular modeling studies using the CXCR4 crystal structure [11].

Structures of representative examples of a monomeric cyclic pentapeptide - based CXCR4 antagonist, two dimeric derivatives and a dimeric Ga - labeled DOTA complex [81].

The dimeric or tandem dimer versions of EosFP are preferred over the monomeric one since the formation of mEosFP's chromophore requires a temperature below 30 °C and this is not ideal for experiments in mammalian cells.

The Amrose FP precursor, eqFP615, was derived from the dimeric eqFP578.

A portion of the pIgR, termed the secretory component, remains bound to the dimeric IgA, and is an integral part of secretory IgA, increasing its resistance to proteases.