Sentences with word «dimerization»

Such a finding suggested that the treatment of EGFR - related lung cancers with the usual small molecule inhibitory drugs would not be successful (patients harboring these mutations are typically resistant to these drugs), while antibodies that interfere with dimerization of EGFR would be effective.

After induction of interferon - stimulated genes (ISGs), the ubiquitin - specific protease USP18 docks to the receptor complex via STAT2, thus interfering with receptor dimerization and STAT phosphorylation.

It contains motifs that are responsible for dimerization, nuclear translocation and binding to NF - κB - binding motifs that are present in DNA.

Envisioning GFP as a substrate promoting dimerization,

«PTEN dimerization may be the key to understanding an individual's susceptibility for PTEN - sensitive tumors,» said Lösche, a professor of physics and biomedical engineering at Carnegie Mellon.

These materials are sensitive to light, and cause the nanoparticles to self - assemble through a photo - dimerization process — crosslinking — when subjected to light at a wavelength of 365 nanometers.

Cellecta's unique multiplex primer design minimizes primer dimerization and cross-reactivity while maximizing specificity and efficacy.

The FPX method is based on green and red dimerization dependent fluorescent proteins (ddFPs) that Campbell and coworkers first reported in 2012.

Prof. De Meyts assures that «Prof. Maruyama makes a convincing case that this [dimerization] model is incorrect, and that in fact, numerous cell membrane receptors are pre-dimerized in the membrane and are activated allosterically by ligand binding.»

Prof. Maruyama suggests that rotation of a receptor's transmembrane region requires less energy than lateral movement of monomeric receptors inside the fluid membrane proposed by the «dimerization theory.»

In order to reveal how dimerization improves PTEN's ability to thwart tumor development, researchers needed to establish the protein's dimeric structure.

For DNA cleavage to occur, two zinc finger proteins must bind, each to specific, adjoining sequences in the CCR5 gene, leading to FokI dimerization and subsequent DNA cleavage resulting in a double strand break [24]--[26].

We analyzed the influence of a pH - shift over the course of antibody storage using ELISA and investigated antibody dimerization at acidic and neutral pH as well as differences in the IgG subclass distributions among the IVIG using both HPLC and a nephelometric assay.

His graduate work at Yale University involved making lots of mutations in the transmembrane region of the epidermal growth factor receptor (EGFR) and collecting data on which mutations affected dimerization.

STAT1 and STAT2 represent two of the seven mammalian STAT proteins that share several structurally and functionally conserved domains, including an NH2 - terminal coiled - coil region for interactions with other transcription factors and chaperone proteins, a phosphotyrosine - binding Src homology 2 domain required for receptor binding and STAT dimerization, and a COOH - terminal transcription activation domain (TAD) within which a highly conserved tyrosine residue is present.

Dimerization seems to be enhanced for eqFP615, but in the case of eqFP650, the absorption and excitation spectrum match indicating a lower tendency to form non-fluorescent dimers.

In addition to receptor binding, the assays measure key events along the ER adverse - outcome pathway, such as receptor dimerization, DNA binding, transactivation, gene expression, and cell proliferation.

The side chain of D -[NMe] Orn2 represents, within the peptide, the «least important residue», amenable to acylation, and therefore it has been used as an anchor point for dimerization, leading to derivative 33 (Figure 7)[81, 83].

Envisioning GFP as a substrate promoting dimerization, Tang et al. tested pairs of their GFP - binding proteins (GBPs) to find those that could co-occupy GFP.

According to the previous «dimerization» model, prior to ligand binding receptors exist in monomeric form.

But the fact that the protein pairs up is surprising, he says, and «you rarely see a dimerization domain that isn't important.»

In naïve cells, receptor dimerization is effectively induced by all IFNs, leading to phosphorylation of pre-associated STAT1 / STAT2 / IRF9 complexes, which subsequently form the transcription factor ISGF3.

We could unambigously demonstrate that dimerization of the receptor subunits is induced by ligand binding.

After further modifications of FC131, including an N - methylation and the introduction of a side chain, aimed at affinity enhancement, compound 32 was selected for a dimerization study.

Tanaka T, Nomura W, Narumi T, Masuda A, Tamamura H. Bivalent ligands of CXCR4 with rigid linkers for elucidation of the dimerization state in cells.

Gesicle loading utilizes the iDimerize system, which enables inducible protein - protein interactions: The membrane - bound CherryPicker red fluorescent protein on the surface of the gesicle is tagged with one dimerization domain, and the Cas9 endonuclease contains another dimerization domain.

We deleted the phosphate sensing PAS domain [14] from PhoR and made fusions at both the conserved DHP domain (Dimerization and Histidine Phosphotransfer) and the charged region (CR).

(A) Eph receptor - ephrin binding at cell - cell contact sites results in the dimerization / clustering of Eph receptor - ephrin complexes, and initiation of canonical signals through the receptor cytoplasmic domain.

Determined the reaction thermodynamics of potential CO2 reduction catalysts for complexation and dimerization