Sentences with word «dimethylation»

G9a (EHMT2) and GLP (EHMT1) catalyze the mono and dimethylation of lysine 9 of histone 3 (H3K9) and other non-histone substrates such as p53 and WIZ.

In addition, SGC0946 potently reduces H3K79 dimethylation with cellular IC50 of 2.6 nM in A431 cells, and 8.8 nM in MCF10A cells.

In cell studies, SGC0946 reduces H3K79 dimethylation with an IC50 of 2.6 nM in A431 cells and 8.8 nM in MCF10A cells.

Significant reduction in H3K9 dimethylation at 100nM in MDA - MB231 cells as measured by fluorescence immunostaining without significant cellular toxicity.

To examine the chromatin structure of rice centromere 8, Nagaki et al. [6] used ChIP - PCR with antibodies against two different covalent modifications of the canonical H3 histone protein (rather than the centromere - specific CenH3): dimethylation on lysine 9 (dimethyl - K9), which has been shown to be enriched in heterochromatic regions, and dimethyl - K4, which is present in euchromatic portions of the chromosome.

Selective Recognition of H3.1 K36 Dimethylation / H4K16 Acetylation Facilitates the Regulation of All - trans - retinoic Acid (ATRA)- responsive Genes by Putative Chromatin Reader ZMYND8.

Research Paper G9a stimulates CRC growth by inducing p53 Lys373 dimethylation - dependent activation of Plk1 Jie Zhang, Yafang Wang, Yanyan Shen, Pengxing He, Jian Ding, Yi Chen Theranostics 2018; 8 (10): 2884 - 2895.

For the first time ever, the study used this formation of novel enhancer regions to describe the selection of enhancers and the progression of the activation from transcription factor binding to histone acetylation and eRNA transcription, finally leading to the mono - and dimethylation of histone H3 lysine 4 (H3K4me1 / 2).

UNC0638 exhibits a dose - dependant reduction in H3K9 dimethylation, while being more potent and efficacious than BIX - 01294.

On the other hand, the dimethylation of the amino group led to a loss in activity (compound 119).