Sentences with phrase «direct cell reprogramming»

Neurons created from neural stem cells derived using a new direct cell reprogramming methodMINGLIANG ZHANG, PHD, GLADSTONE INSTITUTES (VIA EUREKALERT) Researchers have developed a method to directly reprogram cells using a combination of nine chemical compounds.

Not exact matches

However, in 2007 Professor Wilmut announced that he had decided to change to an alternative method of research pioneered in Japan, known as direct reprogramming or «de-differentiation», which could create human embryonic cells without using human eggs or cloning human embryos.

In the direct reprogramming, the researchers exposed the adult skin cells to a specific mix of signaling molecules the scientists» past research had found would convert healthy skin cells directly into a type of brain cell called medium spiny neurons, without intermediate steps along the way.

Subsequent procedures included mammalian somatic cell nuclear transfer, cell fusion, induction of pluripotency by ectopic gene expression, and direct reprogramming.

But like the medieval alchemists, today's cloning and stem cell biologists are working largely with processes they don't fully understand: What actually happens inside the oocyte to reprogram the nucleus is still a mystery, and scientists have a lot to learn before they can direct a cell's differentiation as smoothly as nature's program of development does every time fertilized egg gives rise to the multiple cell types that make up a live baby.

«By gaining direct access to the cytoplasm of the cell we have achieved genetic reprogramming at an incredible high efficiency.

In a commentary accompanying the new study, Dolly cloner Ian Wilmut and his co-worker Jane Taylor of the University of Edinburgh in Scotland wrote that «a modified approach to direct reprogramming... is likely to be the ultimate method of choice for producing human stem cells.»

«Dolly the Sheep told me that nuclear reprogramming is possible even in mammalian cells and encouraged me to start my own project, wrote Yamanaka, who splits his time between the University of California, San Francisco, and the Center for iPS Cell Research and Application (CiRA) at Kyoto University in Japan, which he directs.

Induced pluripotent stem cells are generated by direct reprogramming of adult liver and stomach cells.

The question is now whether these cells, these pericytes are also permissive for direct lineage reprogramming?

Those cells can be reprogrammed into, or directed to become, the type of brain cells most affected in Huntington's disease.

This webinar will cover the following topics: first, I will try to explain, in a few slides, the basic concept underlying direct lineage reprogramming; that is the reprogramming of one cell type into another without going through a pluripotent intermediate.

Review conceptual and technical aspects of direct reprogramming of somatic cells, such as fibroblasts and astrocytes, into induced neurons.

BB: Thank you, Sarah, for this kind introduction and thanks to Abcam for organizing this webinar, and thank you, the audience, for attending this webinar about Direct Reprogramming of Somatic Cells into Induced Neurons.

It would also have been nice to see a mention of direct reprogramming, the latest stem cell technology that may one day make even iPSCs obsolete.

Also, rather than using such compounds to reprogram cells all the way back to the pluripotent state, we are also working on more direct ways to change one type of cell directly into another.

Since the late 1980s, researchers had used «direct reprogramming» to, for example, make different types of adult cells turn into muscle cells.

In the following year, the direct reprogramming of human somatic cells was accomplished [2], [3].

His lab has pioneered the generation of clinical grade induced pluripotent stem (iPS) cells using non-viral reprogramming methods such as direct delivery of reprogrammed proteins and novel episomal methods, and has recently identified novel mechanisms underlying metabolic reprogramming during human induced pluripotency.

The lab pioneered the generation of safe human iPS cells via the direct delivery of reprogramming proteins.

The scientists also used the chemicals to improve direct cardiac reprogramming of human cells, which is a more complicated process that requires additional factors.

The crux of the discovery, published online Tuesday by the journals Cell and Science, is a «direct reprogramming» technique that adds a cocktail of four genetic factors to run - of - the - mill human skin cells.

Secondly, considering that direct reprogramming is a slow and inefficient process, especially for human cells, it is desirable to have feeder cells which can last long enough for reprogramming to proceed.

However, direct cellular reprogramming that does not involve a stem cell state solves some of the safety concerns surrounding the use of stem cells.

Direct reprogramming could revolutionize the field of regenerative medicine, as it lets scientists transform one adult cell type into another without first having to revert back to the stem cell state.

Melton is also a pioneer in direct cellular reprogramming research — the transformation of one type of adult cell into another, without first going through a stem cell state.

This next generation of direct reprogramming builds on the reprogramming method discovered by Gladstone investigator Shinya Yamanaka, MD, PhD, who found that, by using four genetic factors, adult cells can be reprogrammed to pluripotent cells known as induced pluripotent stem (iPS) cells.

Two studies demonstrate the first direct, chemical reprogramming of mouse and human skin cells into heart muscle and neural cells.

Direct conversion or reprogramming of human postnatal cells into endothelial cells (ECs), bypassing stem or progenitor cell status, is crucial for regenerative medicine, cell therapy, and pathophysiological investigation but has remained largely unexplored.

He conducted some of the first studies on direct cellular reprogramming and successfully transformed scar tissue in the heart into healthy, beating heart muscle cells after a heart attack.

Direct reprogramming has been achieved for target cell types such as neurons and insulin - producing beta cells.

In her own lab, she has discovered barriers to direct reprogramming that, when broken down, enhance the conversion of one cell type to another.

And two studies published this summer in Nature Biotechnology found that direct conversion methods to produce neural stem cells that employ the traditional reprogramming genes actually pass the cells through a pluripotent step.

Human pluripotent stem cells derived from embryos (human Embryonic Stem Cells or hESCs) or generated by direct reprogramming of somatic cells (human Induced Pluripotent Stem Cells or hiPSCs) can proliferate almost indefinitely in vitro while maintaining the capacity to differentiate into a broad diversity of cell tcells derived from embryos (human Embryonic Stem Cells or hESCs) or generated by direct reprogramming of somatic cells (human Induced Pluripotent Stem Cells or hiPSCs) can proliferate almost indefinitely in vitro while maintaining the capacity to differentiate into a broad diversity of cell tCells or hESCs) or generated by direct reprogramming of somatic cells (human Induced Pluripotent Stem Cells or hiPSCs) can proliferate almost indefinitely in vitro while maintaining the capacity to differentiate into a broad diversity of cell tcells (human Induced Pluripotent Stem Cells or hiPSCs) can proliferate almost indefinitely in vitro while maintaining the capacity to differentiate into a broad diversity of cell tCells or hiPSCs) can proliferate almost indefinitely in vitro while maintaining the capacity to differentiate into a broad diversity of cell types.

In 2010, Srivastava and a former postdoctoral fellow, Masaki Ieda, PhD, expanded on that breakthrough with direct reprogramming in a dish, which allows scientists to transform one adult cell type into another without first reverting back to a stem cell state.

Methods to reprogram primate somatic cells to a pluripotent state include somatic cell nuclear transfer [2], somatic cell fusion with pluripotent stem cells [3] and direct reprogramming to produce induced pluripotent stem cells (iPSCs)[4]--[10].