Sentences with phrase «directed against a tumor»
The Company focuses on discovering and developing small molecule drugs directed against tumor and immune cell targets that control key metabolic pathways in the tumor microenvironment.
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They then tried adoptive T cell therapy (ACT), in which T cells directed against a tumor are infused into a patient.
«Vaccine directed against tumor blood vessels suppress tumor growth, metastasis.»
Not exact matches
A highly specific polyclonal rabbit antiserum directed against murine cachectin / tumor necrosis factor (TNF) was prepared.
Researchers used tissue and blood samples to show that the gammopathy (a precursor to myeloma) in both mice and patients with Gaucher disease is triggered by specific lipids, and that the antibodies made by tumor cells in nearly a third of myeloma patients are directed against such lipids.
Because the vaccine causes the body to mount an immune response directed against a unique tumor, the therapy is much more effective than gene - targeted or more general chemotherapy alone.
We report here the adoptive transfer, to patients with metastatic melanoma, of highly selected tumor - reactive T cells directed against overexpressed self - derived differentiation antigens after a nonmyeloablative conditioning regimen.
«Surprisingly, the immune response directed against these bacteria helps the patient to better fight his / her tumor, by stimulating fresh immune defence mechanisms.»
James P. Allison and Matthew Krummel demonstrate that a monoclonal antibody directed against the CTLA - 4 molecule in a mouse model of melanoma could result in the rejection of tumors and that this rejection also resulted in immunity to a second exposure to tumor cells.
The mechanism of action is based on the activation of macrophages to defend against tumors by direct tumor cytotoxicity and consequently they secrete cytokines which recruit secondary immune cells, presenting antigen to T cells [5 - 7].
Researchers publish preclinical data suggesting the promise of a novel drug directed against a novel target n malignant mammary tumors...