Sentences with phrase «directed against antigens»
Not exact matches
We report here the adoptive transfer, to patients with metastatic melanoma, of highly selected tumor - reactive T cells directed against overexpressed self - derived differentiation antigens after a nonmyeloablative conditioning regimen.
http://science.sciencemag.org/
*** It is directed against the 5T4 / WAIF1 tumour antigen, a protein found on many different solid tumours and is thought to contribute to the spread of cancer cells.
DC are the most influential APC, playing a key role in directing cellular and humoral immune responses against self and non-self antigens 110.
The mechanism of action is based on the activation of macrophages to defend against tumors by direct tumor cytotoxicity and consequently they secrete cytokines which recruit secondary immune cells, presenting antigen to T cells [5 - 7].
This leads the immune system to direct antibodies against the healthy tissue - not just antigens - causing swelling, pain, and tissue damage.
When the amino acid sequence is homologous between the target antigen, such as gluten, against which the immune system is mounting a response, and tissue proteins, such as the thyroid tissue, a case of mistaken identity occurs, and the immune response can become directed against self tissues, manifesting as autoimmune disease (Hashimoto's thyroiditis in this instance).
She explained that when you give a vaccine antigen, which is the protein of the virus or bacteria you're immunizing against, you actually neutralize any existing antibody directed specifically against that same antigen.