Recently, Dr. Ding achieved entirely gene - free chemical reprogramming, using only drugs to turn fibroblasts
directly into brain cells.
Some researchers have been trying an alternative route: engineering gene - delivery vehicles such as viruses to transfer neurotrophic - factor genes
directly into brain cells.
Not exact matches
In the direct reprogramming, the researchers exposed the adult skin
cells to a specific mix of signaling molecules the scientists» past research had found would convert healthy skin
cells directly into a type of
brain cell called medium spiny neurons, without intermediate steps along the way.
But scientists are making progress in refining these therapies, and the first ever trial of fetal stem
cells injected
directly into the
brain is currently under way in children with Batten disease, a rare and fatal illness of the nervous system.
In the
Cell Stem
Cell study, Zhiheng Xu of the Chinese Academy of Sciences in Beijing sidestepped the mice's natural resistance to Zika virus by injecting a Samoan isolate
directly into fetal
brains.
Scientists are hopeful that ultimately these
cells could be transformed in the laboratory to yield specific
cell types needed for a particular treatment, or to cross the «blood -
brain barrier» by expressing specific therapeutic agents that are released
directly into the
brain.
Rather, parasites move
directly from the blood
into endothelial
cells, where they replicate, cause the
cell to burst and then infect neighboring
brain cells.
For them, Levin thinks «there's a kind of twitchy program going on» in which photosensitive
cells — the researchers aren't sure which ones — bypass the
brain and
directly spur the muscles
into movement.
In this method, skin
cells are turned
directly into brain, heart, liver, or pancreas
cells without going through a stem
cell stage first.
These
cells have the ability to cross the blood -
brain barrier and travel
directly into the nervous system to improve blood flow to the
brain and repair some of the nerve damage which has occurred as a result of your degenerative disease or neurological injury.
The treatment makes these ganglion
cells act like photoreceptors, responding to patterns of light that pass through the retina and converting them
into patterns of electricity that go
directly to the
brain.
Human skin
cells have also been
directly converted
into neurons that can be used to study and find treatments for diseases in the
brain, as well as liver
cells and insulin - producing
cells of the pancreas.
«Our approach could lead to a simpler method of creating iPSCs or could be used to
directly reprogram skin
cells into other
cell types, such as heart
cells or
brain cells.»
The team managed to transform astrocytes (a type of supporting
cells in the
brain)
into neurons
directly within the
brain of rats.