The team was led by Barton Haynes, M.D., director of the Duke Center for HIV / AIDS Vaccine Immunology - Immunogen Discovery (CHAVI - ID) and the Duke Human Vaccine Institute, and John Mascola, M.D.,
director of the Vaccine Research Center of the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health.
«It's a nice tool to have in our arsenal,» says virologist Gary Nabel,
director of the Vaccine Research Center at the National Institute of Allergy and Infectious Diseases in Bethesda, Maryland.
However, widespread vaccination «is going to be hard to justify,» argues Gary Nabel,
director of the Vaccine Research Center at the National Institutes of Health in Bethesda, Md..
Not exact matches
Dr. Larry Corey, Principal Investigator, HIV
Vaccine Trials Network; Past President and
Director, Fred Hutchinson Cancer
Research Center Dr. Diane Havlir, Professor
of Medicine, University
of California, San Francisco Moderator: Siobhan O'Connor, Time Magazine
Developing a
vaccine against HIV is still our best hope for containing the AIDS pandemic, says Danilo Casimiro, Merck's
director of basic
vaccine research.
«Even with the new immunological studies, we can't tell what's special about the whole - cell
vaccine that makes it better,» says Kathryn Edwards, the director of the Vanderbilt University School of Medicine Vaccine Research
vaccine that makes it better,» says Kathryn Edwards, the
director of the Vanderbilt University School
of Medicine
Vaccine Research
Vaccine Research Center.
«Funding and commercial support are increasing in the area
of vaccine R&D, especially because of the high investment by entities such as the NIH and the Bill & Melinda Gates Foundation,» noted Marie - Paule Kieny, director of the WHO's Initiative for Vaccine Re
vaccine R&D, especially because
of the high investment by entities such as the NIH and the Bill & Melinda Gates Foundation,» noted Marie - Paule Kieny,
director of the WHO's Initiative for
Vaccine Re
Vaccine Research.
«Based on epidemiological studies, the 9vHPV
vaccine could prevent approximately 90 percent
of cervical cancer, 90 percent
of HPV - related vulvar and vaginal cancer, 70 to 85 percent
of high - grade cervical disease in females, and approximately 90 percent
of HPV - related anal cancer and genital warts in males and females worldwide,» explained Anna R. Giuliano, Ph.D.,
Director of the Center for Infection
Research in Cancer at Moffitt.
Maria Elena Bottazzi leads the
research, education and administration efforts
of the school, is a Professor
of Pediatric Tropical Medicine and the Deputy
Director for the Sabin
Vaccine Institute and Texas Children's Hospital Center for
Vaccine Development.
A team
of scientists at the
Vaccine Research Center (VRC)
of the National Institute
of Allergy and Infectious Diseases, part
of NIH, created VRC07 - αCD3 under the leadership
of VRC
Director John R. Mascola, M.D.; former VRC Director Gary J. Nabel, M.D., Ph.D.; and Richard A. Koup, M.D., VRC deputy director and chief of its immunology lab
Director John R. Mascola, M.D.; former VRC
Director Gary J. Nabel, M.D., Ph.D.; and Richard A. Koup, M.D., VRC deputy director and chief of its immunology lab
Director Gary J. Nabel, M.D., Ph.D.; and Richard A. Koup, M.D., VRC deputy
director and chief of its immunology lab
director and chief
of its immunology laboratory.
Based at the Cancer
Research Institute in New York, Old is the
director of the Cancer
Vaccine Collaborative, an international program dedicated to fighting cancer from the inside out.
One goal
of the study is to demonstrate the prevalence
of H. influenzae in the region, explains Joel Ward,
director of the Center for
Vaccine Research at the University
of California, Los Angeles, and scientific adviser to IVI.
«An RSV
vaccine with this M2 - 2 deletion could tip the balance toward a better immune response, which is what we predicted based on earlier laboratory studies,» says study leader Ruth A. Karron, MD,
director of the Center for Immunization
Research and a professor in the Department
of International Health at the Bloomberg School.
Kosten is also
researching vaccines for methamphetamines and opiates, which are among several anti-addiction shots that have the keen interest
of the National Institute on Drug Abuse, says NIDA
director Nora Volkow, a
research psychiatrist who has used brain imaging to investigate the addictive properties
of drugs.
Before the announcement, Marie - Paule Kieny,
director of the World Health Organization's Initiative for
Vaccine Research, told the news service: «I don't think that there is a lot of expectation that the efficacy of this vaccine will be very high.
Vaccine Research, told the news service: «I don't think that there is a lot
of expectation that the efficacy
of this
vaccine will be very high.
vaccine will be very high.»
A summary
of its recommendations, endorsed by WHO
Director - General Margaret Chan on 11 July, was released in a statement today and discussed during a press briefing (audio file) by Marie - Paule Kieny, head
of WHO's Initiative for
Vaccine Research.
The
research was led by the paper's senior author, James Crowe Jr., M.D., the Ann Scott Carrell Professor and
director of the Vanderbilt
Vaccine Center.
«We thought we would need five different sets
of vaccines or five different (drugs),» said James Crowe Jr., M.D., the Ann Scott Carrell Professor and
director of the Vanderbilt
Vaccine Center, who led Vanderbilt's end
of the
research.
In a previously published paper, Barouch and colleagues, including Colonel Nelson L. Michael, MD, PhD,
director of the Military HIV
Research Program at the Walter Reed Army Institute
of Research (WRAIR) and Stephen Thomas, MD, Upstate Medical University, State University
of New York, demonstrated that three different
vaccine candidates provided robust protection against Zika virus in both mice and rhesus monkeys.
Regulatory affairs is the name
of the game at the FDA, in Washington, D.C., and the specialized aspect
of reviewing and evaluating drugs or
vaccines means there's significant training after hire, says Kathryn Carbone, associate
director for
research at the Center for Biologics Evaluation and Research
research at the Center for Biologics Evaluation and
ResearchResearch (CBER).
«The pace
of preclinical and early clinical development for Zika
vaccines is unprecedented,» said Barouch, corresponding author and
director of the Center for Virology and
Vaccine Research at BIDMC.
«This is an important demonstration
of the possibilities opened up for immunotherapy by DMAb technology to direct in vivo production
of antibodies
of major relevance to human cancer,» said David B. Weiner, Ph.D., executive vice president
of The Wistar Institute,
director of The Wistar Institute
Vaccine & Immunotherapy Center, W.W. Smith Charitable Trust Professor in Cancer
Research, and senior author
of the study.
«Despite substantial public health efforts, flu
vaccine rates for U.S. children are well below national targets,» says lead author Sarah J. Clark, M.P.H., associate
director of the University
of Michigan C.S. Mott Children's Hospital National Poll on Children's Health and associate
research scientist in the U-M Department
of Pediatrics.
«Taken together, these two studies suggest that the new scalable
vaccine formulation is likely to prove as effective as the original formulation — which would make it the first protective TB
vaccine in humans since BCG, which was introduced almost a century ago,» said Professor Ajit Lalvani,
Director of the Tuberculosis
Research Centre, National Heart and Lung Institute, Imperial College London and a member
of the DAR - 901 development team.
«Many physicians reported tension between the need to build trust with families by being willing to compromise on the schedule while simultaneously feeling they were putting children at risk and causing them unnecessary pain by spreading out
vaccines on multiple visits,» writes Allison Kempe, MD, MPH, professor
of pediatrics and
director of ACCORDS (Adult and Child Center for Health Outcomes
Research and Delivery Science) at the University
of Colorado School
of Medicine and Children's Hospital Colorado.
«We previously showed that adenovirus vector - based HIV - 1
vaccine candidates offered partial protection against SIV when given alone,» said lead author Dan H. Barouch, M.D., Ph.D., director of the Center for Virology and Vaccine Research at BIDMC and professor of medicine at Harvard Medical
vaccine candidates offered partial protection against SIV when given alone,» said lead author Dan H. Barouch, M.D., Ph.D.,
director of the Center for Virology and
Vaccine Research at BIDMC and professor of medicine at Harvard Medical
Vaccine Research at BIDMC and professor
of medicine at Harvard Medical School.
«This
vaccine is a successful advancement in developing control strategies for Zika virus by creating widespread immunity in susceptible populations,» said Stephen Higgs,
director of the Biosecurity
Research Institute.
But Michael Osterholm,
director of the Center for Infectious Disease
Research and Policy at the University
of Minnesota in Minneapolis, says authorities should have been prepared to deploy the
vaccine more quickly.
From that chat has arisen plans for the MSD Wellcome Trust Hilleman Laboratories — named after a
vaccine scientist who worked at Merck — a non-profit
research institute that it will act like a nimble biotech company with «dynamic decision - making» in the words
of Ted Bianco,
director of technology transfer at the Wellcome Trust.
As VRC
Director, Dr. Mascola provides scientific leadership to the basic, clinical, and translational
research activities
of the VRC; develops
vaccine research programs to meet public health needs; allocates VRC resources; and develops policies for the execution
of multi-disciplinary
research.
Dr. John Mascola is
Director of the Dale and Betty Bumpers
Vaccine Research Center (VRC) at the National Institute
of Allergy and Infectious Diseases (NIAID), U.S. National Institutes
of Health.
William Schief is a Professor in the Immunology and Microbial Science Department at The Scripps
Research Institute in La Jolla, CA,
Director for
Vaccine Design at the International AIDS
Vaccine Initiative (IAVI), and an Associate Member
of the Ragon Institute
of MGH, MIT and Harvard.
David B. Weiner, Ph.D., executive vice president,
director of the
Vaccine & Immunotherapy Center, and the W.W. Smith Endowed Chair in Cancer
Research at The Wistar Institute, and peers received the 2018 Top Ten Clinical
Research Achievement Award last night at the National Press Club in Washington, D.C.
Dr. Pontiano Kaleebu, Chairman Africa AIDS
Vaccine Program and Acting Director of Uganda Virus Research Institute, delivered a strong keynote address that reiterated the importance of an HIV vaccine, what it will take to develop an effective vaccine and how community members can help with the international
Vaccine Program and Acting
Director of Uganda Virus
Research Institute, delivered a strong keynote address that reiterated the importance
of an HIV
vaccine, what it will take to develop an effective vaccine and how community members can help with the international
vaccine, what it will take to develop an effective
vaccine and how community members can help with the international
vaccine and how community members can help with the international effort.
«The two greatest challenges remaining in HIV / AIDS
research are finding a cure and developing a safe and effective preventive
vaccine,» said Anthony S. Fauci,
director of the National Institute
of Allergy and Infectious Diseases, which is leading the
vaccine trial.
VIDD
Director Dr. Julie McElrath has called the approach «the next wave»
of HIV
vaccine research.
Dr. Merlin Robb, Deputy
Director of Clinical
Research participated in a panel discussion entitled, «Progress Toward an HIV
Vaccine.»
Since immune responses to
vaccines can differ around the world, these findings are encouraging for the development
of an effective Ebola
vaccine for Africa,» said Merlin Robb, M.D.,
Director for Clinical
Research at the US Military HIV
Research Program (MHRP), whose site in Uganda, Makerere University Walter Reed Project (MUWRP), conducted the study.
He is the recipient
of several awards and honors, including the NIH
Director's Translational
Research Award and the
Vaccine Industry Association Outstanding Academic
Research Laboratory.
There are many variations
of H1N1, says Rafi Ahmed,
director of the Emory
Vaccine Center and a Georgia
Research Alliance Eminent Scholar, but this technology could be used to identify a very specific strain, such as the one weâ $ ™ re dealing with in the current pandemic.
«This finding is consistent with a hypothesis generated out
of the follow - up studies to the RV144 HIV
vaccine trial in Thailand that showed the first efficacy in humans,» noted COL Nelson Michael,
Director of the U.S. Military HIV
Research Program at the Walter Reed Army Institute
of Research.
Weiner joined The Wistar Institute as the Executive Vice President,
Director of the
Vaccine & Immunotherapy Center, and W.W. Smith Charitable Trust Professor in Cancer
Research in 2016.
Dr. Marie - Paule Kieny was
Director of the WHO Initiative for
Vaccine Research (IVR) from 2001 - 2010.
He was requested by Dr. Vasee Moorthy, Head
of the WHO Initiative for
Vaccine Research, and recommended for the WHO assignment team by Dr. Barney Graham, Deputy
Director of the NIH
Vaccine Research Center (VRC), and Colonel Nelson Michael,
Director of the MHRP.
Glenda Gray, executive
director of the Wits Health Consortium's perinatal HIV
research unit in South Africa, presented data today at the HIV R4P conference in Cape Town indicating that the prime - boost
vaccine candidates initially tested in the RV144 trial in Thailand — the only HIV
vaccine trial to date to show any efficacy — induced cross-clade immune responses in a Phase I safety trial conducted in South Africa, with immunogenicity similar to or greater than that
of the responses induced in Thai volunteers.
Old, who also heads the Ludwig Institute for Cancer
Research (LICR) New York Branch and has served for many years as
director of LICR's worldwide scientific programs, says that, eventually,
vaccines will treat a wide variety
of cancer types, recruiting the immune system to stop the progression
of patients» tumors and helping to fully stabilizing the disease.
The Wistar Institute was awarded a $ 1,494,972 grant by the Bill & Melinda Gates Foundation to advance a DNA - based
vaccine candidate for protection against malarial infection utilizing a synthetic DNA platform created in the lab of David B. Weiner, Ph.D., executive vice president, director of the Vaccine & Immunotherapy Center at The Wistar Institute and the W.W. Smith Charitable Trust Professor in Cancer Re
vaccine candidate for protection against malarial infection utilizing a synthetic DNA platform created in the lab
of David B. Weiner, Ph.D., executive vice president,
director of the
Vaccine & Immunotherapy Center at The Wistar Institute and the W.W. Smith Charitable Trust Professor in Cancer Re
Vaccine & Immunotherapy Center at The Wistar Institute and the W.W. Smith Charitable Trust Professor in Cancer
Research.
«The approval
of a
vaccine to treat cancer is a victory in the history
of cancer therapy, and signals the beginning
of a new era in cancer medicine,» said Jill O'Donnell - Tormey, Ph.D., executive
director of the U.S. - based Cancer
Research Institute (CRI), a nonprofit organization founded in 1953 that has provided decades
of significant support to cancer immunology researchers around the world so that the development
of cancer immunotherapies such as Dendreon's Provenge might one day be possible.
However, Gladstone Insitute
of Virology and Immunology
director, Warner Greene, says that a
vaccine is still the Holy Grail in HIV
research.
«A team
of scientists here at NIAID worked tirelessly to rapidly develop this
vaccine for clinical testing,» Dr. John Mascola, director of NIAID's Vaccine Research Center, said in the sta
vaccine for clinical testing,» Dr. John Mascola,
director of NIAID's
Vaccine Research Center, said in the sta
Vaccine Research Center, said in the statement.