Inside the epithelial cell, the tail of E-cadherin binds to a protein called α - catenin, which recruits other proteins that spur assembly and
disassembly of actin filaments and is absolutely critical for strong adherence between epithelial cells.
«These findings demonstrate that efficient
actin filament disassembly by GMF is essential for rapid dynamics
of cell protrusions, and that this dynamics are important for cell migration in a three - dimensional tissue environment,» says Minna Poukkula from the research group
of professor Pekka Lappalainen.