Sentences with phrase «discordant for»

Within - family analyses of the pregnancy outcomes were consistent with a causal interpretation as the associations persisted when siblings discordant for SDP were compared.

Only 21 monozygotic twin pairs out of a total of 74 monozygotic pairs, or 28 percent, were concordant for transsexualism; the remaining 72 percent of identical twins were discordant for transsexualism.

Being bullied as an environmentally mediated contributing factor to children's internalizing problems: a study of twins discordant for victimization.

But Spector argues that EpiTwin has already made valuable contributions — for example, through a study of 15 twin pairs discordant for breast cancer that pointed toward hypermethylation of the DOK7 gene, which he believes could one day be used as a biomarker to help identify women at risk for breast cancer years in advance.

Wednesday, Oct. 18, 9:45 - 10:00 a.m., Room 230C, South Building Platform Presentation: Genome - wide methylomic analysis of neonatal blood from Danish twins discordant for mental illness S. Weinsheimer, iPSYCH, et al

Quantitative Differences in the Urinary Proteome of Siblings Discordant for Type 1 Diabetes Include Lysosomal Enzymes.

Unsupervised clustering proposed a large genetic contribution to the methylation variability as the affected twin from the pair discordant for T2D was epigenetically «closer» to his / her unaffected co-twin than to the other diabetic twins.

Differences in methylation between monozygotic twin pairs discordant for T2D were subsequently modest.

Fourteen MZ twin pairs discordant for T2D were recruited through Scandinavian twin registries (18)(Table 1).

Our aim was to dissect molecular mechanisms underlying T2D using genome - wide expression and DNA methylation data in adipose tissue from monozygotic twin pairs discordant for T2D and independent case - control cohorts.

We therefore analyzed CNVs in MZ twins discordant for T2D and filtered CNVs present in two or more individuals of the same status.

In this study, we capitalized on the strengths of a twin study design to present for the first time both genome - wide mRNA and DNA methylation profiles in adipose tissue from MZ twin pairs discordant for T2D.

We also identified copy number variants (CNVs) in monozygotic twin pairs discordant for T2D.

MZ twin pairs discordant for T2D are rare, and our relatively small sample size increases the risk of type II errors.

We next studied the global DNA methylation pattern with the Infinium HumanMethylation450 BeadChip in adipose tissue from 14 twin pairs discordant for T2D.

After correction for multiple testing, Ribel - Madsen et al. (13) identified two CpG sites with methylation differences of > 3 % in adipose tissue of five twin pairs discordant for T2D.

Heritability of cortical thickness changes over time in twin pairs discordant for schizophrenia

Twins discordant for obesity provide an opportunity to examine interrelations between obesity and its associated metabolic disorders, diet, and the gut microbiota.

We transplanted fecal microbiota from adult female twin pairs discordant for obesity into germ - free mice fed low - fat mouse chow, as well as diets representing different levels of saturated fat and fruit and vegetable consumption typical of the U.S. diet.

Separate groups of germfree mice were colonized with uncultured fecal microbiota from each member of four twin pairs discordant for obesity or with culture collections from an obese (Ob) or lean (Ln) co-twin.

Ridaura et al. (1241214; see the Perspective by Walker and Parkhill) obtained uncultured fecal microbiota from twin pairs discordant for body mass and transplanted them into adult germ - free mice.

Moreover, in the case of identical twins who are discordant for schizophrenia, the child of the healthy twin is as likely to be schizophrenic as the child of the schizophrenic twin.

Not exact matches

When the U.S. tone strikes a discordant note however, there are opportunities to look to Canada and Mexico as platforms for North American trade, in the event the U.S. pulls out of NAFTA and decides to go it alone.

Praise for an avowed supporter of the Tamil Tigers seems discordant coming Tony the Tory.

«It is one of these issues that seems discordant with what our country stands for.»

These terms represent two continua rather than discrete categories: a contrast of discordant disparity, for instance, is identified only in relation to other contrasts in the particular event under scrutiny.

No scheme of analysis could account for all gradations of relative scale, so I have begun with a simple division into contrasts of relative parity or disparity and contrasts that are discordant or concordant.

Into this evolution enter all the expansive, retrogressive, and discordant qualities which account for the perennial struggle present in the religious response to life.

When this occurs, the inherently self - surpassing quality of the feelings of subjectivity, which may either overreach themselves in an expansive quality that knows no bounds or else become blocked by retrogressive and discordant tendencies, instead forms the basis for the religious mode of experience «at the width where the «self» has been lost, and interest has been transferred to coordinations wider than personality» (AI 368).

The painting might seem rather discordant but for its one unifying element: the lamp, with its warm glow piercing the isolation.

The time for tension in our soul is over, and that of happy relaxation, of calm deep breathing, of an eternal present, with no discordant future to be anxious about, has arrived.

Suppose that for some reason the chemical doctrine had been highly prized throughout some district as the foundation of its social order — would it have been wise, would it have been candid, would it have been moral, to forbid the disclosure of the fact that the experiments produced discordant results?

Given the discordant mix of voices assembled for the series — Jesus Seminar scholars, a womanist theologian (Townes), a process theologian (Cobb), and the likes of Hauerwas and Sample — one has to have a seminary degree to detect the real theological battlelines.

The failure to realize a higher form of perfection is preferable for Whitehead: «Progress is founded upon the experience of discordant feelings.

There is one discordant note: he ran the New York City Marathon in a slow (for him) 3 hours and 27 minutes.

Newmania, Its always good to hear from you, and not unusual for you to be a discordant voice.

And there was the discordant thud last Wednesday night, when Assembly Speaker Carl Heastie, a Democrat, and Senate Majority Leader John Flanagan, a Republican, declared they were sending their members home without doing one of the few things that actually came with a deadline: extending mayoral control for New York City's schools, a system that both houses and parties view as a vast improvement over the old system of board control.

For all the unity themes Cuomo had sought this week, the de Blasio snafu was a discordant note.

Further complicating matters, treatment makes infected people less infectious and is a form of prevention itself; next week, the World Health Organization is expected to recommend that all infected people in discordant couples receive ARVs — a huge challenge for many resource - limited countries.

«Our results in prairie voles have identified a biological mechanism that could explain the link between discordant drinking and relationship breakdown, but we will need to do further work to confirm this for humans,» says Ryabinin.

«The discordant twin design minimizes a number of potentially confounding factors that may explain the association between childhood verbal ability and subsequent alcohol use by «controlling» for differences on variables [such as] socioeconomic differences or family factors that, if excluded, could cloud the interpretation of findings.»

Hirnschall explains that a group of outside experts began a review of the evidence late last year before making five recommendations for discordant couples.

WHO had planned to release «discordant» couple guidelines, in the works for several months, at the Rome gathering, but pulled the plug at the eleventh hour.

A discordant name for a dwarf planet.

Several candidate genes for obesity and T2D (e.g., IRS1 and VEGFA) were differentially expressed in discordant twins.

The identification of CNVs in the discordant twins provides an additional potential explanation for phenotypic variation within MZ twin pairs.

DNA methylation was analyzed in adipose tissue of discordant twins, case - control cohort 2, and the twin cohort for heritability estimates using Infinium HumanMethylation450 BeadChips (Illumina).

«These results, and in particular those regarding discordant siblings, strongly suggest that the association between cesarean delivery and childhood obesity is real, rather than an issue of inadequate control for shared causes as we and others had proposed,» he said.

While Anderson's usual traits are accounted for — a conspicuous, often discordant soundtrack; cracks at consumerism; strokes of surrealism — Punch - Drunk Love is Anderson's first feature - length dance with romance.

For all its disorienting intensity, emphasized by Mica Levi's keening and discordant score, Jackie operates at a chilly remove from the viewer.