Sentences with phrase «discover gene function»

This method is designed to discover gene function and validate candidate genomic sequences involved in human disease.

Not exact matches

This team also discovered 3,200 genes that had fewer loss - of - function or missense mutations than would be expected suggesting that these are likely disease - causing variants that are rare or absent in the population because of their detrimental effect on human health.

The scientists from the Montreal Neurological Institute and Hospital at McGill University, led by Peter McPherson, along with collaborators in Saudi Arabia, Jordan, Germany, and at SickKids Hospital and the University of Toronto, have discovered that a severe form of epileptic encephalopathy is caused by recessive loss - of - function mutations in the gene DENND5A.

The scientists also discovered that the stem cells released tiny packets of microRNA, bits of genetic material that control how genes function.

«Y chromosomes are vital for male development and fertility and it will be fascinating to gain a better insight into the function that these newly discovered genes have in different species,» she says.

After extensive analysis of this new gene, the team discovered that moc1 functions as a chloroplast - specific «Holliday junction resolvase», which Nishimura continues, «is very important in untangling a DNA structure called Holliday junctions.

With rapid advances over the past 10 years in technologies for discovering and analyzing the functions of genes, researchers are now increasingly able to get at the biological roots of complex disorders such as substance abuse and addiction.

These two areas, though, are linked in more ways than just function — the same gene controls the size of each area, Salk researchers led by Dennis O'Leary have now discovered.

Potentially explaining why even healthy brains don't function well with age, Salk researchers have discovered that genes that are switched on early in brain development to sever connections between neurons as the brain fine - tunes, are again activated in aging neuronal support cells called astrocytes.

«The power of this study is that we looked at genes discovered to be over-expressed in patients» tumors and determined their function in kidney cancer, which has not been done on a large scale before,» he says.

Furthermore, half the worm genes have human counterparts, so discovering the function of the worm's genes will help explore what human genes do.

Moving forward, the researchers want to identify the functions of the newly - discovered taste genes.

By measuring gene expression in the transgenic mice using DNA microarrays, researchers discovered 50 biomarkers of gene expression that each indicated declining kidney function.

The next phase of study involving the newly discovered gene mutations will investigate their function using human blood samples at the molecular level.

Among the approximately 100 imprinted genes discovered so far, about half of them, including Igf2, make proteins in the brain, raising the question of whether imprinting errors in genes that control the structure and function of the brain might contribute to mental illness.

In the early 1990s, Adrian Bird of the University of Edinburgh discovered the MeCP2 protein and proposed that it functions as a repressor of downstream genes.

Ruiz - Trillo and his team sequenced the Capsaspora genome in an earlier project and discovered that the amoeba contained many genes that, in animals, are related to multicellular functions.

They analyzed the genome of the common mold Aspergillus and discovered a small cluster of genes whose function was previously unknown.

A study investigating the function of the recently discovered enhancer RNA molecules may open new avenues for gene therapy.

When the data was sorted and refined, the scientists discovered that patients who benefited from the immunotherapy treatment with longer survival and progression - free survival were those whose tumors lacked a functioning PRBM1 gene.

Next, the researchers discovered a set of genes and compounds that can transform these cells into functioning liver cells.

Other labs will pitch in for the final assembly and annotation of the genome, as well as analyzing the functions of the new genes discovered.

The regulation of the CAMP gene by vitamin D was discovered by Gombart, and researchers are still learning more about how it and other compounds affect immune function.

Reanimation of genes in living cells allows us to discover the function of that prehistoric information in ways that studying genetic code alone can never provide.

The authors highlight the importance of measuring the variability of transcript expression and location in so many cells by using their data to discover genes with related functions in the cell.

Test each mutant mouse line (4,000 mouse lines in the first 5 years, and ultimately up to 20,000) through a broad based primary phenotyping pipeline in all the major adult organ systems and most areas of major human diseases.Through this activity and employing data annotation tools, systematically aim to discover and ascribe biological function to each gene, driving new ideas and underpinning future research into biological systems.

Working with touch - insensitive mutants, Chalfie's group has discovered that five of these 17 genes are responsible for cell development, twelve for cell function.

By labeling HAR1 molecules in human and macaque embryos, we discovered that the RNAs functioned in neurons during patterning and layout of the cortex, 6 a brain structure that expanded greatly in size during human evolution.7 Exactly which genes HAR1 is regulating remains to be determined.

This project will discover genes that control cuticle development and function in corn, evaluate the potential for improvement of the leaf cuticle to help produce crops with increased drought tolerance and resistance to diseases, and generate tools to guide these efforts.

The mapping of the genome was finished in 2003, and scientists are continuing on the quest to discover what each gene does and how it functions.

Her current research is focused on discovering how normal and disease melanocyte cell states establish distinct regulatory DNA landscapes, and also determining how the combination of both genetic variation within these regulatory regions and environmental cell signals alter gene expression and normal cell function.

«We have discovered that the AaMYB1 gene has a dual function: it promotes trichome formation in the leaves and artemisinin synthesis inside the trichomes», explains Soraya Pelaz, ICREA researcher at CRAG and senior author of the article.

Using weighted gene co-expression network analysis, we discovered that amylin treatment influenced two gene modules linked with amyloid pathology: 1) a module related to proinflammation and transport / vesicle process that included a hub gene of Cd68, and 2) a module related to mitochondria function that included a hub gene of Atp5b.

Results: We discovered stable epigenetic signatures which define regional differences in gut epithelial function, including induction of segment - specific genes during cellular differentiation.