Melton and colleagues are now doing large scale screening with microarrays to track gene activity as cells develop and
discover gene products that move cells along the proper paths.
Not exact matches
It is likely that previously uncharacterized
gene products with intriguing effects on behavior will be
discovered within these networks.
Other scientists (including Jay Keasling, last year's
DISCOVER Scientist of the Year) are having great success adding handfuls of
genes to E. coli and other microbes to make a variety of valuable
products, including medicines and jet fuel.
It will potentially eliminate the need to sequence around a newly
discovered disease SNP to find the variant that actually alters the
gene product, says NHGRI Director Francis Collins.
«We may have
discovered a major step toward developing a «dream tool» for remotely controlling neural circuits, by manipulating specific cells using engineered
gene products that respond to magnets,» said Ali Deniz Güler, a UVA biology professor who led the study in his neuroscience lab.
The
product of the p53 tumor suppressor
gene is
discovered independently by several groups: Lionel Crawford and David Lane; Albert Deleo and Lloyd Old; and Arnold Levine.