Now we know how it does this: its active ingredient targets a newly
discovered type of cell that lowers the immune response.
Not exact matches
Nathaniel Hoyle
of the MRC Laboratory
of Molecular Biology in Cambridge, UK, and his colleagues have
discovered that genes in a
type of skin
cell switch on and off during day - night cycles.
In the present study, the researchers have
discovered a reason for reduced fertility in people with autoimmune polyendocrine syndrome
type 1 (APS1), which increases the risk
of developing autoimmune disease (caused by the immune system attacking and damaging healthy
cells) and which is often used as a model for autoimmune disease in general.
«We and others have been following this family tree from one daughter
cell to the next to
discover how each
cell type is created and how the parent
cell «decides» if it should make more
of itself or create the next
cell type.
The
cells are a recently
discovered type of immune
cell called Th17.
The origin
of these complex
cell types has long been a mystery to the scientific community, but now researchers from Uppsala University in Sweden have
discovered a new group
of microorganisms that represents a missing link in the evolutionary transition from simple to complex
cells.
A panel
of small molecules that inhibit Zika virus infection, including one that stands out as a potent inhibitor
of Zika viral entry into relevant human
cell types, was
discovered by researchers from the Perelman School
of Medicine at the University
of Pennsylvania.
The circuit Hasan's group has
discovered consists
of three
types of nerve
cells — one set senses and reports the lack
of protein in food, a second set integrates this input with metabolic information and the third set controls the hormonal signals necessary to begin pupation.
The newly
discovered human
cells, named «cord - blood - derived embryonic - like stem
cells» or CBEs, are not quite as primitive as embryonic stem
cells, which can give rise to any tissue
type of the body.
The researchers
discovered that both
types of cells shut down when the mice were infected with malaria.
Building upon their earlier research on the biology
of fat metabolism, Joslin scientists
discovered that microRNAs - small RNA molecules that play important roles in regulation in many
types of tissue — play a major role in the distribution and determination
of fat
cells and whole body metabolism.
A University
of Wyoming faculty member led a research team that
discovered a certain
type of soil bacteria can use their social behavior
of outer membrane exchange (OME) to repair damaged
cells and improve the fitness
of the bacteria population as a whole.
They
discovered that
cells respond to ubiquitin modification
of SIRT1 differently according to the
type of environmental insult that occurs.
A possible fix arose in 2003, when researchers
discovered that certain genes can transform the
cells supporting the hair
cells into both
types of hair
cell.
A research group led by Kobe University Graduate School
of Medicine Ph.D. student KATSUNUMA Sayaka and Assistant Professor TOGASHI Hideru
discovered the mechanism for a mosaic pattern formation
of two different
cell types.
The researchers
discovered that FT was also produced in the same
type of companion
cells in the phloem
of Maryland Mammoth tobacco.
In 2010, it was
discovered that enhancers directed expression
of RNA on a broad scale in neurons and macrophages, a
type of immune system
cell.
Harvard School
of Public Health (HSPH) researchers have
discovered that a particular
type of protein (hormone) found in fat
cells helps regulate how glucose (blood sugar) is controlled and metabolized (used for energy) in the liver.
In experiments in mice, UC San Francisco researchers have
discovered that regulatory T
cells (Tregs; pronounced «tee - regs»), a
type of immune
cell generally associated with controlling inflammation, directly trigger stem
cells in the skin to promote healthy hair growth.
Spanish scientists have
discovered that melatonin consumption helps control weight gain because it stimulates the appearance
of «beige fat», a
type of fat
cell that burns calories in vivo instead
of storing them.
The research team with international collaborators analysed more than 100 patient samples from ovarian and other cancer
types to
discover a distinct population
of cells found in some tumours.
An international team
of scientists, led by Monash Biomedicine Discovery Institute researcher Dr Di Yu, and Dr Axel Kallies from the Walter and Eliza Hall Institute, have
discovered that killer T
cells, a specialised
type of white blood
cells, can find these «hidden» infected
cells in tissue and destroy them.
The researchers
discovered that this Treg
cell type plays a decisive role in the development and manifestation
of allergic asthma.
Rutgers University scientists have
discovered the three - dimensional structure
of a gene - specific transcription activation complex, providing the first structural and mechanistic description
of the process
cells use to turn on, or activate, specific genes in response to changes in
cell type, developmental state and environment.
The researchers
discovered that this region is required to both turn Sox2 on, and for the embryonic stem
cells to maintain their characteristic appearance and ability to differentiate into all the
cell types of the adult organism.
The researchers
discovered that
cell divisions that deviate from this norm always result in two different
types of cells.
One
of the team's most exciting new observations suggests a link between autism and a
type of neural stem
cell called outer - radial glia (oRGs),
discovered by the Kriegstein lab in 2010.
They tried hundreds
of different recipes; eventually they
discovered that if they mixed liver precursor
cells (derived from iPS
cells) with two other
types of standard human
cell lines known to be important for embryonic liver development, then the
cells would spontaneously form a 4 to 5 - millimeter 3D structure called a liver bud.
Salk Institute scientists have
discovered the holy grail
of endless youthfulness — at least when it comes to one
type of human kidney precursor
cell.
Phages, shown here surrounding and attacking a bacterial
cell, are part
of a newly
discovered type of immunity that protects mucus - covered human tissue from bacterial infection.
Nathaniel Hoyle
of the Laboratory
of Molecular Biology in Cambridge, UK, and his team have been investigating how the time
of day affects wound healing, after they
discovered that genes in a
type of skin
cell switch on and off during day - night cycles.
Now, Professor Martin and colleagues have
discovered that in response to specific
types of cell damage, Parkin can trigger the self - destruction
of «injured» nerve
cells by switching on a controlled process
of «cellular suicide» called apoptosis.
Scientist at the University
of Bonn and TU Munich have now
discovered that
type I IFN released by immune
cells due to increased migration
of gut bacteria into the cirrhotic liver incapacitate the immune system.
Researchers from immune biology professor Annette Oxenius's group have now
discovered what keeps NK
cells from killing off their «colleagues from the other department»
of the immune system: healthy CD8 +
cells are able to detect the immune messenger substance
type 1 interferon, which binds to specific receptors on the surface
of these immune
cells and thereby conceals their stress.
«We also
discovered that this
type of regulation is, interestingly, specific to beta
cells, and not seen in other metabolic
cell types such as liver and fat
cells,» he says.
Gladstone investigators also
discovered that the p75 neurotrophin receptor — a protein long known for its role in the development
of brain
cells — plays unexpected roles in metabolic disorders, such as
type 2 diabetes.
Scientists have
discovered a completely new
type of opal formed by a common seaweed which harnesses natural technology by self - assembling a nanostructure
of oil droplets to control how light reflects from its
cells to display a shimmering array
of colors...
Salk Institute scientists
discover new
type of stem
cell that could potentially generate mature, functional tissues
Gladstone scientists have
discovered how to make the three
types of heart
cells — cardiomyocytes, endothelial
cells, and smooth muscle
cells — out
of a new
type of cardiac stem
cell created in a lab.
Surprisingly, they
discovered that fibroblasts, connective tissue
cells that are one
of the most abundant
types of cells in the mucosa, greatly increase HIV infection
of immune
cells.
Additional CD4 + T
cell types have been
discovered, including those producing IL - 17 (Th17
cells), that likely participate in the induction
of IBD.
Researchers from the Sloan - Kettering Institute, led by Dr. Lorenz Studer, have
discovered a novel
type of neural stem
cell, which has a broader differentiation potential than previously identified neural stem
cells.
Scientists at the Gladstone Institutes have
discovered how to make a new
type of cell that is in between embryonic stem
cells and adult heart
cells, and that may hold the key to treating heart disease.
In 2010, Kriegstein's lab
discovered a new
type of neural stem
cell in the human brain, which they dubbed outer radial glia (oRGs) because these
cells reside farther away from the nurturing ventricles, in an outer layer
of the subventricular zone (oSVZ).
We have gone on to show that the sensitivity
of the germ line genome instability differs across inbred strains
of mice, offering a unique opportunity to use systems genetics approaches to
discover the underlying pathways governing
cell division and survival across a variety
of cell types.
Embryonic stem
cells,
discovered in the Department
of Genetics in the 1980s (for which Sir Martin Evans was awarded the Nobel Prize in Physiology or Medicine 2007), have become an important tool for developmental biology, understanding disease, and in regenerative medicine due to the ability to give rise to all
cell types in culture.
By understanding how certain brain
cells are either vulnerable or resistant to neurodegenerative diseases, the lab has also
discovered specific «profiles»
of vulnerable
cell types, thus advancing neuroprotective strategies for Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis (ALS).
Instead, they
discovered that each V. carteri
cell type expresses orthologs
of genes from different temporal phases
of the light — dark cycle in a related unicellular alga, Chlamydomonas reinhardtii, with somatic
cells enriched for expression
of dark - phase genes, and gonidial
cells enriched for expression
of light - phase genes.
«We
discovered what looked to us to be an entirely distinct
type of cell,» says Steinman.
In addition, in collaboration with the Harvard Medical School bioinformatics team, he
discovered (4) how global parameters
of the transcriptome differ between various
cell types.