Sentences with phrase «discovery efforts»

Several novel therapeutic targets have already been identified, and drug discovery efforts continue.

Your college alumni network or even your high school alumni network can be persuaded to help you in your book discovery efforts even more easily than the media can.

The SDDC consists of the top Structural Genomics groups in North America, collaborating to support structure - guided drug discovery efforts for high - value targets.

Glycomine will use the proceeds from this financing to complete IND enabling pre-clinical studies and initiate clinical studies of its substrate replacement therapy in patients with Congenital Disorder of Glycosylation Type Ia (CDG - Ia), and to accelerate discovery efforts towards an enzyme replacement therapy for N - glycanase deficiency (Ngly1).

But last week, at a meeting of the European Astronomical Society (EAS) here, astronomers lamented the way the system has thwarted discovery efforts so far — and announced new efforts to probe it.

Species discovery efforts are usually hampered by under - sampling, he adds, but because of his continent - wide collecting, the study enjoys an unusually large sample.

Patent litigation, including managing electronic discovery efforts, working with expert witnesses to draft invalidity and non-infringement reports, drafting claim construction briefs and motions for summary judgment, and pre-trial preparations.

David also helped to coordinate discovery efforts in this MDL proceeding that encompassed hundreds of fact and expert witnesses» discovery and depositions.

Moderna led discovery efforts and is leading preclinical development.

Chemogenomics is a new concept where drug design and screening is conducted at the genome level for selective drug discovery effort against one target among a large family of related proteins / receptors.

The RBL, one of 11 in the country, serves as a valuable shared resource to others in academic, not - for - profit and private sectors for BSL - 3 training, basic research and translational discovery efforts.

Following completion of a massive epitope discovery effort (also supported by an HHS contract), current work on MTB includes development of tools to isolate MTB - specific T cells (supported by the Gates Foundation) and identifying T cell signatures that distinguish three possible infection states: cleared infection, stable latent infection, and latent infection with high risk of progression to disease (in conjunction with a large consortium led by Henry Blumberg at Emory University).

While the extensive discovery efforts were ongoing Pearson, Simon & Warshaw also participated in numerous mediation sessions, jointly and with individual defendants, under the auspices of nationally renowned mediator, the Honorable Daniel Weinstein (Ret.).

To avoid any inconsistencies and inefficiencies when handling discovery in related litigation across multiple jurisdictions, as well as an on - going governmental investigation, members of the eMerge team coordinated discovery efforts by:

Led Data Migration - lead strategy, storage sizing and data discovery efforts with vendor architects and Storage Operations on Data migration of 3PAR Inserv S / T storage arrays with Brocade switches to EMC Symmetrix V - MAX with Cisco Nexxus 7010 Series

«We thought that some knowledge of plant biology could accelerate discovery efforts.»

Our research aims at identifying the principles of neuronal interactions with signals from the cellular microenvironment and uncovering disease - relevant targets that can be harnessed to drive drug discovery efforts in neurological and age - related neurodegenerative diseases.

But last week, at a meeting of the European Astronomical Society here, astronomers lamented that the system has so far thwarted discovery efforts — and announced new schemes to probe it.

Species discovery efforts are usually hampered by under - sampling, but the UMass Amherst - AMNH study enjoyed unusually large sample coverage.

This mechanism includes potential targets for next - generation drug discovery efforts to treat metabolic diseases including diabetes and obesity.

Because of this extensive validation, in the Jimeno lab and elsewhere, the Wnt pathway has been a major focus of anti-cancer drug discovery efforts.

Toxicology, the traditional tests for adverse drug effects, continues to drive early drug discovery efforts.

Attrition of novel drug candidates due to cardiovascular liabilities (including proarrhythmic risk due to delayed ventricular repolarization and Torsades - de-Pointes arrhythmia) remains a hurdle for drug discovery efforts, a hurdle which may be mitigated by the use of human induced pluripotent stem - cell derived (hiPSC)- cardiomyocytes.

«These ligases are being actively developed in drug discovery efforts,» Hogenesch noted.

Some recent additions include: in 2007 GlaxoSmithKline opened a US$ 13 million medicinal chemistry outfit at Biopolis that doubled the company's research staff in Singapore; Eli Lilly's Singapore Center for Drug Discovery plans to boost its drug - discovery efforts, in part, by tripling its research and development staff to 150 within three years; the Novartis Institute for Tropical Diseases has grown to a staff of over one hundred researchers and supporting staff since its inception in 2002.

Diseases of the developing world, such as secretory diarrhea, have little commercial interest for the pharmaceutical industry and represent a gap that is productively filled by academic drug discovery efforts.

This mechanism includes potential targets for next - generation drug discovery efforts to treat met... more

Our departure from this paradigm was to emphasize the intersection of population biology and basic science in our discovery efforts.

So far, this represents an unsolved problem for drug discovery efforts.

A global consortium of HD researchers has just published a landmark study of genetic differences between people that might explain some of that variability, producing some tantalizing new targets for drug discovery efforts.

Since 1997, it has been our mission to provide ubiquitin proteasome pathway (UPP) researchers with innovative tools that facilitate and accelerate drug discovery efforts.

It can be used to study a particular chemical compound of interest in great depth, or in a broader screen at the starting point of a drug discovery effort.

Brent Stockwell, Ph.D., Assistant Professor in the Department of Biological Sciences and the Department of Chemistry at Columbia University leads drug discovery efforts.

There are, however, several challenges to generate soluble and stable complexes, and this is one of the many reasons why not many X-ray structures are available, especially at resolutions suitable to drive drug discovery efforts.

Pharamaceutical companies» decision is judicious, investment in this technology now may cut down future funding and even accelerate drug discovery efforts.

For instance, having executives travel with forensically clean laptops and smartphones reduces the number of devices to search during a discovery effort, while offering outsiders fewer windows onto proprietary company information.

Mend your current fractured, fragmented and disjointed e ‑ discovery efforts.

The desired outcome of any electronic discovery investment should be a reduced discovery bill and the more expeditious completion of the discovery effort.