New York, NY — January 31, 2006 — The Spinal Muscular Atrophy Foundation announced the completion of a new licensing agreement that will facilitate access to intellectual property fundamental to drug
discovery efforts for the disease.
Not exact matches
Health care companies have also continued to expand their research and development
efforts, resulting in innovative
discoveries as well as cures and treatments
for many diseases.
Wine brands are using humor as a vehicle
for education, but Gallo has discovered that any
effort that encourages wine drinkers to explore, experiment and embark on a journey of
discovery will bring the industry closer to reducing fear among budding oenophiles.
The ACCC's
effort to sever an alliance of interest between Coles and a popular platform
for petrol price
discovery has taken a huge leap forward.
When Ricardo said, «I make a daily
effort to make a culinary
discovery here in México, not abroad,» I couldn't help but ask him: «Are you saying that French cuisine,
for example, is not important
for you?»
The
discovery of novel health effects of bioactive compounds will provide the scientific basis
for future
efforts to use biotechnology to modify / fortify foods and food components as a means to improve public health.
(While this was also arguably the original goal of academies / universities centuries ago, the modern university model has become a vocational school of sorts — preparing students
for success in future endeavors, rather than seeking
discovery, enlightenment, and progress through the
efforts of its constituents.
These
discoveries were made by oncologist Dr. Michael Kühn from the Department of Internal Medicine III, which is a part of the University Center
for Tumor Diseases (UCT) at the Mainz University Medical Center, in a collaborative
effort with researchers from the Memorial Sloan - Kettering Cancer Center in New York and Harvard University in Boston.
Academic
efforts in drug
discovery also exist at other institutions, such as Baylor University's Center
for Drug
Discovery, Harvard University's Laboratory
for Drug
Discovery in Neurodegeneration, and many others.
This
discovery is important
for maternal health and
for our
efforts to develop preventive measures to minimize miscarriages, which are a big health problem
for women in the affected areas of Africa.»
The
effort has already had one practical result: the
discovery of two new genes
for resistance to a race of wheat stem rust to which there is virtually no resistance in wheat.
This
discovery serves as a stepping - stone
for the team's ongoing
effort to theoretically understand 3D NEC in quantum materials, and to experimentally probe 3D NEC in different ways.
Their
discovery of the LDL receptor and their
efforts to understand how the protein functioned are credited with laying the foundation
for the development of the blockbuster class of cholesterol - lowering statin drugs.
Companies in the partnership supply compound libraries and drug
discovery expertise to the
effort, while academic partners contribute knowledge about the disease and facilities
for screens and assays.
Chemogenomics is a new concept where drug design and screening is conducted at the genome level
for selective drug
discovery effort against one target among a large family of related proteins / receptors.
Toxicology, the traditional tests
for adverse drug effects, continues to drive early drug
discovery efforts.
Attrition of novel drug candidates due to cardiovascular liabilities (including proarrhythmic risk due to delayed ventricular repolarization and Torsades - de-Pointes arrhythmia) remains a hurdle
for drug
discovery efforts, a hurdle which may be mitigated by the use of human induced pluripotent stem - cell derived (hiPSC)- cardiomyocytes.
Topics ranged from the political (Vienna - based astrophysicict Mazlan Othman, who may have the best business card in the world as she is the director of the United Nations Office
for Outer Space Affairs, discussed her duties and called
for an international protocol on dealing with the possible detection of life in outer space) to the philosophical (theologian Ted Peters of University of California, Berkeley, discussed the significance of the
discovery of extra-terrestrial life
for the world's religions) to the positively apocalyptic (astrophysicist Frank Drake, the original champion of the search
for extra-terrestrial intelligence
efforts, pondered whether a technologically advanced civilization would inevitably use its power to annihilate itself.).
This year, Hummels will serve as one of 46 NASA Student Ambassadors, selected
for their outreach
efforts and
for their ability to generate public attention
for NASA's space
discoveries during the International Year of Astronomy.
According to the researchers the methodology they employed
for this study allowed them to make an important
discovery without investing more money in genotyping or more
effort to recruit volunteers.
Already the National Science Foundation, through its Planetary Biodiversity Inventories
for select groups of organisms has shown that intense, team
efforts can speed the
discovery and classification of unknown organisms, says meeting organizer Quentin Wheeler from Arizona State.
The
discovery, the product of a multiyear
effort to provide a high - quality full genome map of the oil palm plant and to scour the sequence
for genes of importance to both science and industry, has major implications
for agriculture and the environment.
The question now, experts said, is what the
discovery of the bottoms - up ice formation means
for efforts to understand ice sheet behavior and to investigate past climate by extracting ice cores.
Now, translational research has emerged as a field in its own right, aided in large part by the National Institutes of Health (NIH) Roadmap
for Medical Research, a collection of initiatives that prioritize
efforts to shepherd biomedical
discoveries into clinical application.
«Techniques like this one that enable controlled, remote C - H activation are just beginning to be adopted by industry, and should provide a boost to drug
discovery and development
efforts for many years to come,» Yu said.
The convergence of several factors explains the trend: cheaper genetic sequencing technologies, the
discovery of new oncogenes (genes that can cause a normal cell to become cancerous), a new generation of computers and bioinformatics that can analyze vast amounts of data, and a multibillion - dollar
effort by researchers inside and outside the pharma industry to develop targeted drugs and companion diagnostics
for cancer.
A $ 1.7 million drug
discovery effort to identify molecular and genetic risk factors and new therapeutic targets
for cognitive decline and Alzheimer's disease, based on data from the Religious Order Study and the Rush Memory and Aging Project.
«This
discovery highlights the need
for increased study throughout the tropics,
for example Manu NP and its surrounding areas have been well studied, but despite these
efforts, new species are being continuously discovered,» points out first author Alex Shepack, a PhD student in the laboratory of co-author Dr Alessandro Catenazzi at Southern Illinois University.
Long - term monitoring
efforts that supported this
discovery are vital as we continue to monitor changes in the Arctic and develop tools to support adaptation planning
for both wildlife and people.»
This mechanism includes potential targets
for next - generation drug
discovery efforts to treat metabolic diseases including diabetes and obesity.
This mechanism includes potential targets
for next - generation drug
discovery efforts to treat met... more
A co-founder of Tenaya Therapeutics, he was also chosen
for his
efforts to bring his
discoveries to market to fight the world's leading cause of death — heart disease.
In order to most rapidly realize the value of genetics
for human health, deCODE is currently partnering with life sciences companies to accelerate their target
discovery, validation, and prioritization
efforts, yielding improved patient stratification
for clinical trials and essential companion diagnostics.
What's next: Important follow - on studies include using these initial
discoveries to design targeted
efforts for understanding the specific signaling pathways under EGFR transactivation.
The consolidation of these
efforts in an independent initiative will allow faculty from the CMI to lead a focused investigation in small molecule drug
discovery for multiple therapeutic applications.
Such information will be valuable
for the
discovery of the genetic causes of human diseases and will aid
efforts to identify new drug targets.
ANN ARBOR, Mich. — Sept. 15, 2008 — Assay Designs and the Spinal Muscular Atrophy Foundation (SMAF) are very pleased to announce a collaborative agreement
for development of reagents and assays
for SMN (Survival Motor Neuron) protein to expedite drug
discovery and development
efforts for spinal muscular atrophy (SMA), the leading genetic cause of mortality in infants and toddlers.
Our curated catalog of planet candidates provides a starting point
for future
efforts to confirm and characterize K2
discoveries.
We aim to accelerate the pace and success rate of mRNA
discovery research
efforts for both our ventures and our partners.
This
effort, which will enhance deCODE's proprietary gene and drug target
discovery work and may provide genetic markers
for additional diagnostic development, will leverage Illumina's Sentrix ® HumanHap BeadChips; Infinium ™ assay and LIMS (laboratory information management system); as well as analysis and visualization tools from Illumina's BeadStudio software.
Housed in Switch's Las Vegas SUPERNAP data center and available to UNLV researchers through SUPERNAP's unique connectivity network, «Cherry Creek» received upgrades in 2015, giving UNLV and its research partners access to world - class computing power and acting as a catalyst
for scientific
discovery, the modernization of applications, and regional economic development
efforts.
The RBL, one of 11 in the country, serves as a valuable shared resource to others in academic, not -
for - profit and private sectors
for BSL - 3 training, basic research and translational
discovery efforts.
The new
discovery advances
efforts to find new and effective treatments
for heart failure.
«This funding will help provide important new opportunities to translate basic
discoveries and leading - edge technologies from UC San Diego's research laboratories into needed therapies
for patients — an
effort being spearheaded by our new Drug Discovery Institute,» said Palmer Taylor, PhD, associate vice chancellor
for Health Sciences and dean of the Skaggs School of Pharmacy and Pharmaceutical Sciences.
With the ability to integrate these data sets in a tightly linked, highly annotated manner, Labmatrix has the kind of flexibility, security and data access control today's scientists require
for information management of biomarker
discovery, next generation biobanking, pre-clinical and clinical studies and translational research
efforts.
He is Director of the Joint Center
for Translational Medicine, a collaborative
effort joining Caltech and UCLA in a program translating basic science
discoveries into clinical realities.
«It took our team of researchers and collaborators more than 15 years of diligent
effort to unravel the genetic cause of FOP that had been shrouded in mystery
for so long,» says Fred Kaplan, MD, the Isaac & Rose Nassau Professor of Orthopaedic Molecular Medicine, of the 2006
discovery of the mutation that causes FOP.
Another
effort is to identify genes involved in human development, known as DGAP (Developmental Genome Anatomy Project), which uses naturally occurring human chromosomal rearrangements in association with major congenital anomalies as the biological reagents
for gene
discovery.
Another reason why EPA started with estrogen was that high - throughput in vitro assays were already developed either commercially
for use in drug
discovery by the pharmaceutical industry or through an interagency government
effort called Toxicology Testing in the 21st Century, or Tox21.
Housed in Switch's Las Vegas SUPERNAP data center and available to UNLV researchers through SUPERNAP's unique connectivity network, the «Cherry Creek» supercomputer gives the university and its research partners access to world - class computing power and will act as a catalyst
for scientific
discovery, the modernization of applications, and regional economic development
efforts.