Not exact matches
The first detailed genetic comparison
of purebred domestic
dogs promises to rewrite the textbooks with new information about
breed classification and insights that may improve canine health by boosting understanding
of the more than 350 inherited disorders, including cancer, heart
disease, epilepsy, blindness and deafness, which
affect dogs.
One
of the most common
diseases seen in
dogs, with larger
breeds being the most
affected.
One
of the most common
diseases seen in
dogs, with larger
breeds being the most
affected — ultimately a malfunction
of the hip joints causing a loss
of function.
Methods.:
Dogs of various
breeds,
affected or unaffected with primary glaucoma, were genotyped for the Gly661Arg variant
of ADAMTS10, as well as 7 other nonsynonymous single nucleotide polymorphisms (SNPs) in other genes in the beagle POAG locus that segregate with
disease.
While it is true that no
dog affected with a spinal
disease should be
bred from, there is a great deal
of variance in the appearance
of a French Bulldog's spine as compared to, for example, a Labrador Retriever.
Concurrently a study in Labrador retrievers has identified a mutant variant
of ATP7B (Chr22) the Wilson
disease copper transporter gene in their
affected dogs while COMMD1 does not appear to be involved in
affected dogs in this and other
breeds.
This
disease most commonly
affects small
dog breeds at the age
of five to eight months.
They are also one
of the most frequent ophthalmic
diseases, as well as a major cause
of blindness in
dogs,
affecting both mixed and pure
breeds.
Although it is mostly a
disease of older large or giant
breed dogs, it can
affect dogs of any size or age.
Chronic active hepatitis is and inflammatory
disease of the liver common in small to medium
breed dogs, but can occur in any
breed of dog, male or female, can occur at any age, although most
affected dogs fall in the middle age to senior age range.
Although great strides have been made in identifying genetic markers and developing screening tests for many gene - based
diseases, there are no test yet for PLN, PLE, or RD. Therefore, the
breed club's health committee recommends that close relatives
of dogs with these
diseases not be
bred and that periodic tests be done on the relatives
of affected dogs to determine if the
disease is present and help establish a baseline for research.
Another important fact to remember is to avoid
breeding your
dog — given the genetic component
of this
disease, spaying or neutering
of affected dogs can at least prevent the
disease being passed on.
Beyond the typical thoughts that the good breeders should CERT for hips, eyes and
breed specific
diseases, etc., and know quite a bit about genetics, my criticisms
of breeders, even the so - called good ones, are more social in nature in regard to how they
affect the social lives
of the
dogs they have
bred, their owner selection process, and the possibility
of the
dog's success in staying in a home for life.
Inflammatory bowel
disease can
affect any
dog of any age, or any
breed.
The term, «canine familial dermatomyositis» currently should be reserved for
dogs with clinical and histopathologic evidence
of a juvenile onset heritable inflammatory
disease affecting skin and muscle in a
breed known to be at increased risk.
Dilated cardiomyopathy is a
disease of predominantly large and giant
breed dogs that results in progressive heart muscle dysfunction, chamber dilation, and eventual congestive heart failure or death
of affected patients.
If screening detects that a
dog is predisposed to a genetic
disease (or likely to produce
affected offspring) and / or perhaps already in the early stages
of the
disease, then no
breeding can take place under the scheme.
Inherited
diseases or structural problems such as hip dysplasia, glaucoma, sebaceous adenitis (a skin
disease), various heart ailments, and more tend to
affect many
breeds of dogs.
We have documented SIBO by culture
of duodenal juice in over half
of dogs with chronic intestinal disease; dogs of many breeds are affected, although there is a predominance of German Shepherd D
dogs with chronic intestinal
disease;
dogs of many breeds are affected, although there is a predominance of German Shepherd D
dogs of many
breeds are
affected, although there is a predominance
of German Shepherd
DogsDogs.
Disease of the heart muscle (cardiomyopathy) most commonly
affects larger and giant
breeds of dog
This
disease tends to be primarily genetic in nature and
affects mostly large
breeds of dogs.
This
disease can
affect dogs of all
breeds and ages and, unfortunately, it has no known cause and no cure.
Arthritis is a common
disease affecting cats and
dogs, especially large
breed dogs and senior pets, and can greatly
affect their quality
of life.
In some
breeds, notably Doberman Pinschers, the
disease is often an inherited one and Doberman Pinschers are one
of the most common
breeds of dogs to be
affected with DCM.
While the
disease can
affect any animal,
dogs from the following
breeds may be at an increased risk
of developing Addison's
disease: Standard poodle, Great Dane, Portuguese water
dog, West Highland white terrier, Rottweiler, English springer spaniel, Welsh springer spaniel, German shorthaired pointer, Soft - coated wheaten terrier, Nova Scotia duck tolling retriever, and the Bearded collie.
The
disease itself is painless but
affected dogs should be regularly monitored by an ophthalmologist to treat possible secondary effects
of PRA (the most widespread form
of PRA across
dog breeds) IG - PRA1 first presents as a loss
of vision in dim light conditions due to degeneration
of rod cells in the retina.
Cranial cruciate ligament
disease can
affect dogs of all sizes,
breeds, and ages, but rarely cats.
When first described, one
of the names given the
disease was «chronic osteomyelitis
of young German Shepherd
Dogs,» but as it was studied in subsequent years, other
breeds were found to be
affected, including the Rottweiler, Airedale, Irish Setter, German Shorthaired Pointer, Doberman Pinscher, Great Dane, Basset Hound, and Saint Bernard.
Mitral valve
disease is the most common heart disorder in older
dogs of all
breeds,
affecting more than one third
of dogs over 10 years
of age.
However, cancer is certainly one
of the most serious
diseases your
dog can get, and all
breeds of dogs can be
affected.
This
disease generally
affects the toy
breeds, the Yorkshire Terrier is such type
of breed and if the
dog tends to develop this
disease, it generally appears between birth and the fourth month.
It's an extremely debilitating
disease affecting the quality
of life and mobility
of many
dogs, especially senior aged, large
breeds (and their mixes).
PRA is a group
of eye
diseases that may
affect some
breeds of dogs.
Many consider kidney
disease as the most distressing
of the hereditary
diseases thought to
affect the
breed as is it fatal and causes pain and suffering not just to the
dogs but to owners too who see a much loved
dog fading before their eyes.
Chronic degenerative radiculomyelopathy (CDRM) is a well - recognised neuro - degenerative
disease of unknown aetiology which
affected large
breed dogs, primarily the German Shepherd
Dog (GSD).
In contrast to PRA (Progressive Retinal Atrophy), which is the more common type
of retinal
disease in many
dog breeds, CD does not
affect night vision.
Dr. Jesty and her 10 years experience in companion animal cardiology will present up to date information the diagnosis and treatment
of Boxer Cardiomyopathy (heart
disease), which commonly
affects this loyal
breed of dog.
Near relatives
of affected dogs should not be
bred to mates with a family history
of any autoimmune
disease.
Blood was collected for DNA extraction from a) privately owned crd3 -
affected and non-
affected purebred GIT
dogs; b) mixed
breed dogs derived from GIT founders and maintained as a study colony as part
of an NIH - sponsored project (EY006855) at the Retinal
Disease Studies Facility (RDSF) in Kennett Square, PA; and c) from 80 privately owned pedigreed
dogs from
breeds not known to segregate crd3 (Table 1).
These tests allow breeders to make more informed decisions about which
dogs to
breed and ultimately to reduce the frequency
of dogs affected by
disease.
In the same way that inbreeding among human populations can increase the frequency
of normally rare genes that cause
diseases, the selective
breeding that created the hundreds
of modern
dog breeds has put purebred
dogs at risk for a large number
of health problems,
affecting both body and behavior.
Not only are the genetics
of it so far unknown, but most
affected dogs will not develop the
disease until adulthood making it difficult to
breed away from.
Carrier
dogs can have mild features
of the
disease but when
bred with another carrier
of the same Mutation, there is a risk
of having severely
affected pups.
With less serious simple recessive
diseases breeding of affected dogs should be avoided if at all possible.
However, in a general sense, the decision to test or not should include considerations such as: the seriousness
of the
disease, the reliability
of the test, the prevalence
of the
disease in the
breed, and the presence
of affected or carrier
dogs in the vertical pedigree.
Since the
diseases discussed here are inherited or, in the case
of the autoimmune
diseases, genetically predisposed,
affected dogs generally should not be
bred.
Because
of the hereditary potential
of several
of these rare
diseases, as well as the significant health impacts
of a few
of them, breeders need to make note when cases arise and avoid
breeding dogs with
affected relatives to each other.
The removal
of affected dogs from the
breeding pool has long been and remains an important form
of prevention; the
affected dog necessarily has genes for whatever
disease it has and will pass them to its offspring.
RMSF can
affect dogs of all
breeds, but young purebred
dogs are reported to be more susceptible to developing severe
disease due to Rickettsia rickettsii infection than mixed
breeds.
Simply put, if you
breed an
affected dogs (two copies
of the mutation) to one you want to determine the genetic status for, if you get at least six puppies clear
of the
disease it is at least 98 % likely that the
dog you were testing is clear.