Sentences with phrase «disease course»

Since secondary infections are common in some types of canine liver disease a course of antibiotics might be prescribed.

Twenty percent of dogs have the potential to develop a severe disease course.

«While MyD88 is also a crucial adaptor for most TLR signaling pathways, MyD88 deficiency had no impact on disease course.»

Mast cell disease within the internal organs of cats has a more aggressive disease course.

«What's interesting is that this variability in lesion formation is also seen in humans, where patients with the same genetic mutation often have dramatically different disease courses.»

To stimulate development of Parkinson's disease (PD) therapeutics with potential for fundamentally altering disease course and / or significantly improving treatment of symptoms above and beyond current standards of care.

What little encouraging Alzheimer's treatment data does exist — including that around a promising drug called aducanumab — suggests medications that have gone through clinical trials seem to work better earlier in the dementia disease course, before patients develop full - blown Alzheimer's.

Smokers with a relapsing - remitting multiple sclerosis (MS) are three times more likely to develop a secondary - progressive disease course.

This virus, which is in the same family as Ebola, has a rapid disease course (seven to nine days) in nonhuman primates.

«High levels of the cell signalling protein TNF have been reported in JDM patients with a long disease course, suggesting this immune cell regulator may play a significant role in refractory disease,» said Dr Raquel Campanilho - Marques of the Institute of Child Health, University College London, UK.

«Development of a readily accessible biomarker for the c9FTD / ALS mutation may aid not only diagnosis of these disorders and allow for tracking disease course in patients, but it could provide a more direct way to evaluate the response to experimental treatments,» says co-author Kevin Boylan, M.D., medical director of the Mayo Jacksonville ALS Center, the only ALS Certified Center of Excellence in Florida.

These results support the hypothesis that that all the symptoms and disease courses observed in MS patients are produced by the same underlying mechanisms that damage nerve cells over time.

They found that, by changing the intensity of the underlying biological processes involved in MS at distinct times, they were able to successfully reproduce the variability of disease courses seen in these patients.

For example, patient EM, despite having the worst disease course, had the greatest HAI and MN serum titers.

Chronic lymphocytic leukemia (CLL) is a disease with varying disease course, where some patients can live for a long time while others succumb rapidly to the disease, despite therapy.

If people who take aspirin have a later age of onset of HD symptoms, or a slower disease course, we could guess that the immune reaction observed in HD patients is a bad thing.

Most people who have MS experience a «relapsing - remitting disease course,» which means they get new symptoms or relapses that last several days or weeks; then enter a period of remission.

Resource person for Pennsylvania Department of Agriculture and instructor for poultry disease courses designed for second and third year veterinary students.

Preventive health care tips include identification and minimization of disease risk factors, existing disease course improvement, and early disease detection through screening.

Provide counseling / education to patients and families regarding disease courses; aid patients with defining and compleeting end of life / closure activities; provide anticipatory grief counseling to patient and families; assist patients and families with navigating insurance / Medicare / Medicaid and other government programs

According to Dr. Dotson, the increased usage of corticosteroids and biologic medications among black children in the study could suggest a more severe disease course that may be attributable to worse intrinsic disease in black children.

«Building upon previous data related to the PRSS1 mutations found in patients with early - onset pancreatitis, we learned that combined with our current data, patients with PRSS1 are more likely to have an aggressive disease course,» said Giefer.

Typically, symptoms of ME / CFS begin suddenly following a flu - like infection, but a subset of cases classified by the investigators as «atypical» follows a different disease course, either from triggers preceding symptoms by months or years, or accompanied by the later development of additional serious illnesses.

«For many years, the rheumatology and dermatology communities have been trying to understand which patients with psoriasis go on to develop psoriatic arthritis and how we might detect it earlier in the disease course,» explained senior investigator Cheryl Barnabe, MD, MSc, of the McCaig Institute for Bone and Joint Health and the O'Brien Institute for Public Health, Cumming School of Medicine, at the University of Calgary, Alberta, Canada.

«The more we understand and discover important details such as this, the closer we are to developing treatments that could modify the disease course in patients.»

Further research will investigate whether the disease course, response to treatment and outcomes are dependent on the age of the first pancreatitis attack in children.

The authors suggest that while it is not certain that this particular strategy or drug could be effective, it is possible that either not enough drug was administered or that the drug needs to be administered earlier in the disease course.

«The data also suggest that immunotherapy administered earlier in the disease course is more beneficial, as response rates are much greater in first - compared to second - or later lines of therapy.»

The findings suggest that initiating treatment earlier in the disease course may lead to better outcomes.

HD mutation carriers had neurofilament concentrations that were 2.6 times that of the control participants, and the level rose throughout the disease course from premanifest to stage 2 disease.

«This is how we can start thinking about precision medicine in action,» said the study's senior author, Alice S. Chen - Plotkin, MD, an assistant professor of neurology at Penn. «We found that a relatively common genetic variation can both serve as a biomarker for and influence the disease course of Parkinson's patients.

In general, children with JDM are able to lead normal lives; however, some patients with JDM have a disease course that is refractory to multiple drug treatments.

In a phase II trial described in The Lancet today, Ionis and academic collaborators report that it extended the life spans and improved the motor function of babies with severe SMA, compared with the disease courses in natural history studies of untreated babies.

«Recently, several new compounds have been developed and approved with the aim of favourably changing the disease course, but with varied success,» writes Dr. Loredana La Mantia, Cochrane Multiple Sclerosis Cochrane and Rare Diseases of the Central Nervous System Group, Milan Italy, with coauthors.

«The disease course may last 10 or 20 years.»

In contrast, patient 1009 had relatively low HAI and MN serum titers but the highest frequency of broadly neutralizing antibodies and a less severe disease course.

We have thoroughly validated this approach in multiple animal models, observing marked improvement in modifying the disease course in both mild and severe models of SMA,» said Adrian Krainer, Ph.D., Professor of Molecular Genetics at Cold Spring Harbor Laboratory in Long Island, NY.

Mutations in at least 23 different genes cause autosomal dominant RP, with nearly identical symptoms and disease course.

In line with the objectives of the International Rare Disease Research Consortium (IRDiRC), we aim to develop novel tools that will allow to make more accurate diagnoses, predict the disease course and the efficacy of available treatments, and help developing new and better therapies for rare kidney diseases.

Our results demonstrating Gleevec's high efficacy in CML tell us that in applying the drug to other cancers, we need to diagnose and treat patients earlier in the disease course.

Peripheral T - cell lymphomas (PTCL) represent a heterogeneous clinicopathological entity of non-Hodgkin lymphoma with an aggressive disease course and poor clinical outcome.

Finally, we know that treatment early in the disease course is associated with improved efficacy of drugs and better outcomes, such as reduced risk for surgery.

While of obvious importance to patients, these findings are also tremendously important to hospitals and policymakers who are concerned with initiating palliative care earlier in the disease course.

«The more robust response rates of first - line therapy, compared with second or later lines, suggest that immunotherapy administered earlier in the disease course is more beneficial,» says Dr. Adams.

The really important questions are whether this therapy can be given safely; early in the disease course; and as second - line treatment, replacing an autologous stem cell transplant.

His plan is to sample thousands of tumors from hundreds of cancer patients across their disease course to track where immune checkpoint signaling molecules are distributed.

One clinical trial has begun and others will follow that are large phase III, randomized clinical trials comparing salvage chemotherapy plus autologous stem cell transplant versus CAR T - cell therapy, that is, second - line therapy administered earlier in the disease course.