Sentences with phrase «disease gene silencing»
Dr Carroll, who edited the article, has previously undertaken RNA - targeted Huntington's disease gene silencing research, and is named in an associated patent.
https://en.hdbuzz.net/ Not exact matches
The gene - silencing strategy, in the form of RNA interference, has also showed promise against an uncommon neurodegenerative disease called hereditary ATTR amyloidosis, as my colleague Sy Mukherjee wrote about in Fortune's year - end Investor's Guide.
«These particles, microRNA based SNAs, could also potentially be used for gene silencing in other cancers and diseases of genetic origin.»
RNA interference (RNAi), a technique for silencing genes that shows potential for treating diseases, has been like a hot baseball prospect who hasn't proven he can play in the big leagues.
Being able to detect and measure the amount of mutant huntingtin present in the nervous system will be a valuable way of seeing whether the gene - silencing drug is hitting its target and has the intended effect, lowering the amount of disease causing mHTT protein.
Silencing of one of the «cell death» genes may be the first step in finding treatments to help woman delay menopause or avoid the health problems — osteoporosis, heart disease — associated with the cessation of estrogen production.
ASCB President Don Cleveland of the University of California, San Diego, said his team just published an animal study on a gene silencing therapy for treating a form of Lou Gehrig's disease that they now hope to move to clinical studies.
In September, Alnylam Pharmaceuticals announced that its small RNA molecules silenced the gene that causes the progressive disease hereditary ATTR amyloidosis in a successful phase III trial.
Researchers have collected information on which genes are activated or silenced in certain diseases and by certain drugs for many years.
Drugs capable of activating silenced genes improve survival and growth outcomes in a mouse model of Prader - Willi syndrome (PWS), a rare and incurable childhood disease, according to a study funded by the National Institutes of Health (NIH).
Biologically, hypermethylation often silences genes that keep runaway cell growth in check, and its appearance in the DNA code of breast cancer - related genes shed into the blood may indicate that a patient's cancer growth is increasing and the disease has worsened.
Results with formulations of lipid nanoparticles as agents to deliver siRNAs in animals, including nonhuman primates, 28,29 have shown activity toward silencing of disease - modifying genes expressed in the liver.
If what you've read here about zinc finger technology reminds you of «gene silencing» or «huntingtin - lowering» methods for treating Huntington's disease, give yourself a gold star.
Today brings news that the first Huntington's Disease patients have been successfully dosed with gene silencing drugs targeting the HD gene.
Our proprietary technology can selectively inhibit any gene in the genome, specifically silencing the production of disease - causing proteins.
The new CRISPR technique works by silencing the gene (DUX4) thought to be responsible for the genetic disease.
Our technology is a highly specific and modular platform that enables us to inhibit or «silence» the expression of disease - causing genes, allowing cells to revert to their healthy state.
After huge leaps forward in recent years, we're edging ever closer to human trials of huntingtin lowering or «gene silencing» as a potential treatment for Huntington's Disease.
The length of this «triplet repeat expansion» determines the degree of gene silencing, and thus the severity of the disease.
Cleveland and the members of his lab use these therapies, also known as designer DNA drugs, to silence genes involved in the development of various neurodegenerative diseases such as Alzheimer's, Huntington's and Lou Gehrig's disease.
She leads a team at the UCL Huntington's Disease Centre that is currently conducting a trial of a novel «gene silencing» treatment for HD, sponsored by Ionis Pharmaceuticals.
We are interested in dissecting the mechanisms of epigenetic gene silencing and understanding the functional relevance of DNA methylation in diseases.
So far, we've seen gene silencing drugs tested in several different animal models of Huntington's disease, successfully delaying symptom onset or even reversing symptoms.
By injecting molecules called short interfering RNAs directly into tissue known as the trabecular meshwork, researchers have been able to silence the action of disease - relevant genes.
Mipomersen (Kynamro) reduces low - density lipoprotein (LDL) cholesterol by silencing a gene that produces apolipoprotein B - 100, a building block of LDL; the drug can treat familial hypercholesterolemia, an inherited disease that may cause heart attacks at an early age.
One possible implication of this work is for so - called «gene - silencing» therapies for Huntington's disease, which aim to reduce production of the huntingtin protein, by sticking to its RNA message molecules and telling cells to get rid of them.
Transgenerational effects of caloric restriction on longevity, B - vitamins silencing bad genes, cognitive stimulation revering neurodegenerative disease, exercise increases neurogenesis, and vitamin D controls aging.