Sentences with phrase «disease in rodents»

Birling MC, Herault Y, Pavlovic G. Modeling human disease in rodents by CRISPR / Cas9 genome editing.

- Modelling Human Disease in Rodents with CRISPR / Cas9 Genome Editing: June 27th - Why do the results discovered using genetically engineered mice sometimes fail to translate to humans?

Telomere length predicts both cellular health and disease in rodent models and humans.8 Shorter telomeres predict onset of cardiometabolic diseases of aging.9 Chronic stress is associated with higher inflammation, shorter telomeres, and lower activity levels of telomerase, the cellular enzyme that elongates telomeric DNA.10, 11 Levels of amyloid beta (Aβ) proteins circulating in the blood appear to be stress - related in rodent models12 and may be affected by stress reduction, and greater Aβ42 / Aβ40 ratios are associated with lower risk of dementia.13

There are multitudinous studies where high fat diets with 40 - 60 % calories from fat are used to induce cardiometabolic diseases in rodents, with 10 - 13 % fat diets used as a «healthy» control.

Not exact matches

On steps to be taken to prevent the spread of the disease, Idris urged residents to «avoid contact with rats, ensure proper collection and disposal of waste, cover all foods including left - overs and water properly, wash their hands properly before and after cooking of foods, block all rat hideouts and store food items in rodent - proof containers.»

While the disease remains a modest threat in rural, undeveloped areas, Green warns that our current stable relationship with plague in the developed world is only as good as our control of urban rodent populations.

«Our research shows that focusing surveillance on viruses in bats, rodents and non-human primates (a «SMART surveillance approach), and understanding what's disrupting these species» ecology is the best strategy to predict and prevent local outbreaks and pandemic disease,» Daszak continued.

It causes the disease tularemia in humans, rabbits and rodents, among others.

An inflammatory protein that triggers a pregnant mouse's immune response to an infection or other disease appears to cause brain injury in her fetus, but not the premature birth that was long believed to be linked with such neurologic damage in both rodents and humans, new Johns Hopkins - led research suggests.

As imprinted rodent genes were uncovered, geneticists wondered whether imprinting could explain the puzzle of two apparently unrelated diseases in people, Prader - Willi and Angelman syndromes.

Specifically, the researchers found that in some areas, the number of rodent - eating predators like foxes seemed to move inversely with the prevalence of Lyme disease; when those predators disappear, the disease may get a boost.

The study was done with rodent malaria, but the researchers, at Pennsylvania State University in University Park, expect the pattern to apply to human malaria and possibly to other mosquito - borne diseases such as dengue fever and West Nile virus.

Hantavirus, the pulmonary disease spread by rodents, for example, has been linked to changes in precipitation.

While studying the inflammatory mechanisms underlying colitis in rodents, a team of researchers led by Dana Philpott and Thierry Mallevaey realized that their laboratory mice were more susceptible to developing the disease if their intestines were already infected with the protozoan Tritrichomonas muris.

Studies have shown that exercise can have both structural and cognitive benefits in rodent models of pathological conditions like Fetal Alcohol Spectrum Disorders (FASD) and Alzheimer's disease.

A team of researchers at the University of South Florida investigating the short and long - term effects of ischemic stroke in a rodent model has found that stroke can cause long - term damage to the blood - spinal cord barrier (BSCB), creating a «toxic environment» in the spinal cord that might leave stroke survivors susceptible to motor dysfunction and disease pathology.

Rodents gone mad In other schizophrenia news, a new transgenic mouse may allow researchers to better study the enigmatic disease, which afflicts one percent of people worldwide.

However, since the novel genes that were identified, are known to lead to aging - associated diseases in humans, their further analysis seems to be promising for developing new approaches to understand and possibly cure these diseases and to contribute to a long life and healthy aging in humans — in a way, long - lived rodents do.

Insofar, the results are also relevant for humans: 85 % of the long - lived rodents» genes are identical to human DNA, but in contrast to humans that are rather prone to illness, long - lived rodents have a very low risk to come down with age - related diseases.

Because rats don't develop Peyronie's disease, the researchers had to induce scarring by making incisions in the rodent penises.

The disease — typically spread by fleas that carry the bacteria and can infect humans or small rodents, like rats — remains a threat, with minor outbreaks still common in Africa, the Americas, and Asia.

In June, a review in Trends in Parasitology found that bats carry far fewer infectious diseases than rodentIn June, a review in Trends in Parasitology found that bats carry far fewer infectious diseases than rodentin Trends in Parasitology found that bats carry far fewer infectious diseases than rodentin Parasitology found that bats carry far fewer infectious diseases than rodents.

Summerville and her family live in the worst asthma hot spot in Baltimore: ZIP code 21223, where decrepit houses, rodents and bugs trigger the disease and where few community doctors work to prevent asthma emergencies.

Previous research in rodent disease models has shown that transplanted oligodendrocyte precursor cells derived from embryonic stem cells and from human fetal brain tissue can successfully create myelin sheaths around nerve cells, sometimes leading to dramatic improvements in symptoms.

Research has shown that giving TMAO to rodents promotes atherosclerosis and that humans with higher concentrations of TMAO in the bloodstream are at increased risk of developing heart disease.

In addition, mosquito repellants, such as DEET, and pesticides, such as permethrin, were sprayed on their clothes and tents to keep potentially disease - carrying insects and rodents at bay.

As if chronic fatigue syndrome (CFS) hasn't caused enough brawls, a new study published online by Science links the disease to a possibly contagious rodent retrovirus, XMRV, which has also been implicated in an aggressive form of prostate cancer.

A team led by parasitologist Stefan Kappe at the Center for Infectious Disease Research in Seattle in Washington gave a rodent version of this «genetically attenuated parasite,» or GAP, to mice and showed that they were completely protected when later infected with an unmodified — or wild - type — version of the same Plasmodium strain.

The selective loss of large herbivores, for instance, is known to cause relatively systematic increases in abundance of rodents [71], which are thought to be particularly effective at hosting and transmitting human - borne zoonoses, thus driving landscape - level increases in rodent - borne disease [72].

This pattern may result in more rodent - borne diseases.

General Product Information Obesity - High Fat Diets for Diet - Induced Obesity Models Metabolic Syndrome - Diet - Induced Metabolic Syndrome in Rodent Models Diabetes - High Fructose / Sucrose Diets for inducing Hypertriglyceridemia and Insulin Resistance in Rodents Atherosclerosis - Diet - Induced Atherosclerosis / Hypercholesterolemia in Rodent Models Hypertension - Phenotypic Expression of Hypertension in Rodent Models through Dietary Manipulation NAFLD (Non-alcoholic Fatty Liver Disease) Cancer - Creating a Clean Background for Oncology Research Test Compounds / Kaolin Pellets Diet and Immunology Focus: Arsenic in Grain - Based Laboratory Animal Diets and Effects on the Rodent Toxicological Phenotype Focus: The Importance of a Proper Control Diet

Intrastriatal Transplantation of Adenovirus - Generated Induced Pluripotent Stem Cells for Treating Neuropathological and Functional Deficits in a Rodent Model of Huntington's Disease» from Stem Cell Translational Medicine by Stuart P. Atkinson.

No one yet knows what's actually going on in cells when they're reprogrammed, and cancer is still a very real problem, with most rodents that get iPS cells developing the disease.

Light - activated genes, now illuminating brain circuitry in rodents and monkeys, may help solve mysteries of human disease.

Review of «Intrastriatal Transplantation of Adenovirus - Generated Induced Pluripotent Stem Cells for Treating Neuropathological and Functional Deficits in a Rodent Model of Huntington's Disease» from Stem Cell Translational Medicine by Stuart P. Atkinson.

When the UCSD researchers isolated and shut off mutant SOD1genes in the motor neuron cells only, the disease onset slowed, but the course of the disease eventually caught up to the control rodents.

How about: 1) Heath Hens back and all birds genetically treatable; 2) Passenger Pigeons back; 3) Great Auks back; 4) Black - footed Ferrets disease - free; 5) Northern White Rhinos back; 6) Genetic - rescue tools in wide and responsible use; 7) Asian elephants liberated from lethal herpes; 8) Woolly Mammoths back; 9) Islands liberated from invasive rodents; 10) Lyme disease rare; 11) Hawaiian birds liberated from malaria; 12) A debate tool in use by the general public to work through controversy about new technologies.

Transgenic models session Chairs V.Korinek & Z. Kozmik 16.00 Bohumil Fafílek Cell tracking and manipulation in genetically modified mice 16.30 Michaela Krausová Mouse transgenic model to study tumor progression and metastasis in the gut 17.00 coffee break 17.20 Matej Durik Rodent transgenic models of cardiovascular diseases 17.50 Jan Masek The role of Wnt / beta - catenin signaling in neural crest development: an insight from transgenic and knockout mice 19.00 dinner

As with many human diseases, fatty liver in rodents is also diet - inducible.

For such study, we have used the McGill - R - Thy1 - APP transgenic rat, which is unique compared to other rodent models in that the AD - like phenotype has been achieved with a single genomic insertion of a mutated human APP transgene; minimizing off - target genetic corruption and therefore being closer to the human disease [32].

Last April, at a conference resort next to the Golden Gate Bridge, 52 scientists from around the world spent three days doing case studies on: 1) wildlife diseases with vectors such as mosquitoes, 2) wildlife diseases without vectors, such as chytrid fungus in amphibians, 3) destructive island invasives such as rodents and ants.

The results were obtained from mice and human stem cells in cultivated brain tissue, and from a series of rodent models for human neurodegenerative diseases and acute brain injuries.

Qualified candidate must be a motivated, talented and disciplined scientist having excellent expertise in behaviorally assessing various rodent models of neurodegenerative disease.

Neurological disease from B. burgdorferi infection is also absent in rodents, rabbits and dogs [30].

Landfills breed rodents like rats, mice and insects, who in - turn transmit diseases.

Since the presence of phytoestrogen containing sources (i.e. soy protein and isolated isoflavones) has been found to influence atherosclerosis and lipoprotein metabolism in various rodent models (7 - 13), the use of purified Western - type diets provides a clean «reagent» for inducing this disease.

In a second study, published in the journal Stem Cells Translational Medicine, the team showed that in rodents they could use the same type of lung cell to successfully treat a model of IPF — a chronic, irreversible, and ultimately fatal disease characterized by a progressive decline in lung functioIn a second study, published in the journal Stem Cells Translational Medicine, the team showed that in rodents they could use the same type of lung cell to successfully treat a model of IPF — a chronic, irreversible, and ultimately fatal disease characterized by a progressive decline in lung functioin the journal Stem Cells Translational Medicine, the team showed that in rodents they could use the same type of lung cell to successfully treat a model of IPF — a chronic, irreversible, and ultimately fatal disease characterized by a progressive decline in lung functioin rodents they could use the same type of lung cell to successfully treat a model of IPF — a chronic, irreversible, and ultimately fatal disease characterized by a progressive decline in lung functioin lung function.

This review will highlight commonly used dietary factors able to influence LDL - C and atherosclerosis in various rodent models, as well as some of the potential benefits and drawbacks associated with using these models for disease induction.

Of 69 rodent pairs, 11 did die of «parabiotic disease,» essentially a form of tissue rejection, but in the other pairs, the effects were noticeably positive — although only for the older mice.

Dr. Gage has served in many countries as a short - term consultant on plague and other rodent - borne diseases for the World Health Organization (WHO) and its regional affiliates.