Sentences with phrase «disease locus»
The phrase "disease locus" refers to the specific area or gene on a person's DNA where a disease or condition is believed to be located. It can be thought of as the spot on our genetic material that is associated with causing a particular illness or disorder. Full definition
The small number of samples used for this analysis highlights the power of the canine model system for genetic analysis of traits and implies its potential application to identify other important disease loci in dogs.
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Linkage Mapping of the Primary Disease Locus for Collie Eye Anomaly.
That's a lot of work to pin down the genetic architecture and disease mechanism for a handful of disease loci.
Linkage mapping of the primary disease locus for collie eye anomaly.
Kruglyak also developed the linkage analysis program GENEHUNTER, which has been responsible for the identification of hundreds of human disease loci.
Transcription factors operate across disease loci, with EBNA2 implicated in immunity.
I like this study because it demonstrates the importance of looking at both common and rare variants, in a large number of samples, to more comprehensively interrogate the genome for complex disease loci.
25/4: 00 Imputation of low - frequency variants identifies novel Alzheimer's disease loci in the IGAP Consortium.
Purpose.: Previously, we mapped the disease locus in the beagle model of autosomal recessive primary open angle glaucoma (POAG) to a 4 - Mb interval on chromosome 20, and identified a Gly661Arg variant in ADAMTS10 as the candidate disease - causing variant.
Phylogenetic studies show that the terriers probably share a common ancestry, and combining data from the three breeds will probably not only allow the mapping of the disease locus but may also identify a minimal critical haplotype with a small number of candidate genes, as has been done for other canine diseases (37, 40).