Sentences with phrase «disease model research»

Not exact matches

The role that big pharma plays in research, while valuable, is often tenuous, because profit models for many diseases are not always apparent, at least in the short term.

He conducted his postdoctoral research at Brigham and Women's Hospital / Harvard Medical School, where he researched the role of the Wnt signaling pathway in mouse models of kidney disease, and was part of a team that discovered a stem cell subtype responsible for solid organ fibrosis.

Maine statute directed the committee to develop this model policy based on the current research and best practice guidelines from the national Centers for Disease Control and Prevention and other states» concussion management documents.

The Dr Hadwen Trust for Humane Research claims that «in some instances, reliance on inaccurate animal «models» of human disease have undoubtedly delayed medical progress.»

Protein misfolding and aggregation had been identified as a major factor in mad cow disease, and research using yeasts as model organisms played a large role in those findings.

The researchers, including first author Matheus Victor, PhD, a postdoctoral research associate, set out to generate neurons that would mimic those of adult patients in order to model the onset and progression of Huntington's disease.

«It started to become quite evident to me that a research career in infectious disease epidemiology and mathematical modeling would be a fairly perfect combination of my longstanding interests in math and biology and medicine, as well as my emerging interest in infectious disease transmission and public health more generally,» she says.

We do not cover developments of interest only to specialists, such as new animal models of a disease or the opening of new science research centres.

«We knew that the brain hat was a very high potential» among marchers, says Chris Pierret, a biologist at the Mayo Clinic in Rochester, but his group commissioned crocheted zebrafish hats, honoring one of their favorite disease research models.

The key problem for research on smallpox is that there is no good animal model for the disease.

To study the pathogenesis of HIV - induced PNS disease, Jamie Dorsey, Research Technologist, and the research team led by Dr. Mankowski developed a simian immunodeficiency virus (SIV)- infected macaque model that closely reflects key peripheral nervous system (PNS) alterations seen in HIV patients with peripheral neuResearch Technologist, and the research team led by Dr. Mankowski developed a simian immunodeficiency virus (SIV)- infected macaque model that closely reflects key peripheral nervous system (PNS) alterations seen in HIV patients with peripheral neuresearch team led by Dr. Mankowski developed a simian immunodeficiency virus (SIV)- infected macaque model that closely reflects key peripheral nervous system (PNS) alterations seen in HIV patients with peripheral neuropathy.

«This research has broad impact, because by deepening our understanding of cell reprogramming we have the potential to improve disease modeling and the generation of better sources of patient - specific specialized cells suitable for replacement therapy,» said Plath.

In preclinical studies using cell models that mimicked liver cells of patients with the rare disease Friedreich's ataxia (FA), a widely used cholesterol - lowering drug increased a precursor of HDL (high - density lipoprotein), the «good cholesterol,» according to new research published in PLOS ONE from the Perelman School of Medicine at the University of Pennsylvania.

Even the new studies clashed somewhat: Unlike the UCSF study, the German research found no major differences between the overall microbiomes of twins with and without MS. Finally, mouse models of MS are not perfect mimics of the human disease, and mouse immune systems aren't identical to people's.

When the weather - based model developed at Rothamsted Research was used to predict how climate change may affect the wheat crops, it was predicted that wheat flowering dates will generally be earlier and the incidence of the ear blight disease on the wheat crops will substantially increase.

The new research investigated the effectiveness of MSC therapy in a mouse model of chronic inflammatory lung disease, which reflects some of the essential features of diseases such as COPD and cystic fibrosis.

The research is also the first to demonstrate beneficial effects of UDCA on dopaminergic neurons, the nerve cells affected in Parkinson's disease, in a fly model of Parkinson's disease which carries the same genetic change as some patients with the condition.

For the research, the scientists used the platform to target colon macrophages in order to reduce inflammatory symptoms caused by Inflammatory Bowel Disease (IBD) in mouse models.

For example, rats are often good models for humans in disease research, but they aren't when it comes to pooping because rats are pellet poopers.

The research team also screened candidate drugs using a «disease - in - a-dish» model.

The journal provides cutting - edge research including results from animal models that are likely to apply to patients, studies in human tissue that provide new information about therapies or disease, and innovative reports of drug discovery and development.

«When the Novartis Institutes for BioMedical Research was first founded, we set up a model that would make biology more rational by understanding the molecular pathways of disease,» Elton says.

Another problem is that modeling studies, like this one, are inherently less powerful than other kinds of medical research: randomized clinical trials, the gold standard in medical research, in which patients are randomly assigned different treatments or no treatment; case - control studies, which compare patients who have a condition with those who do not; or cohort studies, which determine the risk of contracting a disease by studying a group of people with similar demographics.

Recently research published in Cancer Discovery showed that changing the schedules of drug administration can improve outcomes leading to more complete responses in mouse models of the disease.

Her research group focuses on developing dynamic models for effective infectious disease management for HIV, hepatitis, and genomics.

This research depicts the findings of Sampson et al., who show that signals from gut microbes are required for the neuroinflammatory responses as well as hallmark gastrointestinal and a-synuclein-dependent motor deficits in a model of Parkinson's disease.

Next, the research team will examine specifically whether these liver cells obtained from human embryonic stem cells in a dish help repair injured livers in preclinical animal models of liver disease.

Most animal studies of the disease are conducted with laboratory mice that have been genetically engineered and bred to model ALS, but for this research, investigators used rats with ALS because they more accurately portray the disease's variable course in humans.

Their previous research, which used an inducible model of periodontal disease, found that Cp40 could reduce signs of the disease.

The model expands the research toolkit for investigations of social behaviors and psychiatric diseases like autism and schizophrenia.

«These results enable future studies in Alzheimer's and other disease models and highlight the importance of basic research which precedes drug - discovery,» says Jaan - Olle Andressoo.

«This research project is a prime example of how mouse models can help us to better understand cancer diseases in human beings,» says Sabine Harlander.

Like humans, songbirds such as zebra finches (above) can learn vocalizations, and this similarity suggests they could serve as models for research on Huntington's disease and other neurodegenerative disorders that affect speech and vocalization.

Kühn has just recently joined the MDC and is head of the research group for «iPS cell based disease modeling.»

In this latest research, Mohan and his colleagues present new findings that detail the use of a synthetic, plant - derived compound — abbreviated CDDO — that was shown to effectively suppress the multiple steps of lupus development in murine models, including the onset of kidney disease.

«The mouse models don't recapitulate the human disease,» said Ravi Basavappa of the National Institutes of Health, which gave Fine one of its 12 Pioneer Awards for «unusually bold,» high - risk, and potentially high - impact research.

«Traditional methods of infectious disease research using animal models have provided limited information about disease progression until the study's endpoint, when investigators could analyze tissues from those animals,» he said.

the National Institutes of Health being the biggest funder but in the case of the flu, the Centers for Disease Control also fund their own research and a little bit about that research, and other countries also have their own ways of funding things, typically government, and the researchers in their current model of working, they are not required to release their scientific data until they publish it.

Reported today in Disease Models & Mechanisms, Karim Si - Tayeb and colleagues in the research group of Bertrand Cariou from l'Institut du Thorax, Nantes used an innovative approach to develop unique patient cell - based models of PCSK9 - driven hypercholesteroModels & Mechanisms, Karim Si - Tayeb and colleagues in the research group of Bertrand Cariou from l'Institut du Thorax, Nantes used an innovative approach to develop unique patient cell - based models of PCSK9 - driven hypercholesteromodels of PCSK9 - driven hypercholesterolemia.

Application of sun protection factor 30 (SPF30) sunscreen prior to exposure to ultraviolet - B (UVB) light delayed melanoma onset in a mouse model of the disease, according to data from a team at The Ohio State University Comprehensive Cancer Center Comprehensive Cancer Center — Arthur G. James Cancer Hospital and Richard J. Solove Research Institute.

However, research at The University of Manchester using higher doses of Genistein Alygone in the mouse model of Sanfilippo Disease has shown that this is effective in reducing neurodegeneration2, 3.

Clinical trials to treat neurodegenerative diseases such as Alzheimer's have a historically high failure rate, partially because potential drugs are derived from research in nonhuman models.

Another experiment, one designed by students, will observe fruit flies as a research model for learning how diseases work at the cellular and molecular levels.

His research focuses on the cancer biology, drug resistance, and signaling pathway networks of human diseases as well as on ways to model these disorders.

Muotri noted that the research represents one of the first efforts to use iPSCs and brain in - a-dish technology to generate novel insights about a disease process and not simply replicate data from other models.

This research is all aimed at tissue repair strategies, but it also may provide new in vitro models for human disease.

Research on Huntington's has thus far relied heavily on animal models of the disease, and has left many key questions unanswered.

Because of these limitations, most pancreatic cancer research relies on genetically engineered mouse models of the disease, which can take up to one year to generate.

But this remarkable therapeutic benefit isn't limited to MS. Previous research in animal models that mimic other diseases suggest that certain forms of amyloids can ease damage from strokes, traumatic brain injuries and even heart attacks.

An international research team led by biochemists at The University of Texas Health Science Center at Houston (UTHealth) reduced the sickling of red blood cells in a mouse model of the disease.