Sentences with phrase «disease models are used»

Furthermore, these disease models are used for drug target identification.

Preclinical studies of the effects on this drug on neurodegeneration have been done but do not appear to have been published so I do not know which disease models were used.

Not exact matches

More broadly, updated longitudinal studies of the natural history of hypertension, diabetes, and cardiovascular disease are needed, because the data from the National Health and Nutrition Examination Survey that we used in our model are somewhat dated.

This is demonstrated in the studies reviewed in the special issue, which use computational models to examine brain processes, such as learning, emotion, dopamine signaling and information processing, and how processes interact in deficits underlying psychiatric disease.

Protein misfolding and aggregation had been identified as a major factor in mad cow disease, and research using yeasts as model organisms played a large role in those findings.

The company provides porcine models of particular diseases, models that are used to develop gene - based treatments and drugs.

«The whole value of model organisms is that they are lean and mean,» so once he has established his proofs of principle, ideally he will be able to use a matrix approach to efficiently tackle many rare diseases simultaneously.

In the present study, the researchers have discovered a reason for reduced fertility in people with autoimmune polyendocrine syndrome type 1 (APS1), which increases the risk of developing autoimmune disease (caused by the immune system attacking and damaging healthy cells) and which is often used as a model for autoimmune disease in general.

These findings allowed researchers to create a chimera virus: a mouse virus with a human viral gene that can be used to test molecules that inhibit human LANA protein in an animal model of disease, treating not only human herpes virus infection but also its associated cancers.

«I had been thinking about model organisms for a very long time in academia, and when I started to realize that there were all these people clamoring for their rare diseases I thought, «Why aren't people using model organisms to study them?

Thomas is a wildlife biologist by training, but he now uses technology such as satellite remote sensing and software applications such as geographic information systems to model vector disease transmission.

Exposed to both air and fluid, the cells might also be used to model the lungs and test drugs for lung disease.

The researchers are beginning to use their model to test whether Zika virus, and other pathogens associated with congenital disease, can infect placental cells and / or cross the placental barrier.

Using iPSCs, researchers developed a novel cellular disease model to probe the neurobiological causes of schizophrenia, which are not well understood (ChangHui Pak, abstract 032.29, see attached summary).

They can also be used to create novel disease models from which new drugs and therapies can be developed.

Zebrafish are commonly used to model human diseases, in part because their larvae are transparent, making it easy to see the effects of genetic mutations or drugs.

When the weather - based model developed at Rothamsted Research was used to predict how climate change may affect the wheat crops, it was predicted that wheat flowering dates will generally be earlier and the incidence of the ear blight disease on the wheat crops will substantially increase.

«Social media data have been suggested as a way to track the spread of a disease in a population, but there is a problem that in an emerging outbreak people also use social media to express concern about the situation,» explains study team leader Sherry Towers of ASU's Simon A. Levin Mathematical, Computational and Modeling Sciences Center.

This proof - of - principle study shows «for the first time... that human iPS cells can be used to model a diverse range of inherited diseases in adult cells,» the authors wrote in their paper, published online in The Journal of Clinical Investigation August 25.

Satellite imagery is used for all sorts of climate study, from identifying conditions that allow infectious diseases like West Nile virus and cholera to emerge, to creating models for predicting hurricanes, to distinguishing natural resources such as wind, water and sunlight.

Realistic stem cell therapies to replace diseased or damaged tissue may still be years away, but researchers have uncovered a promising new use for these undifferentiated cells: they can be programmed to become patient - specific laboratory models of inherited liver disease.

This weather - based model was then used to predict the impact on severity of the disease of future weather scenarios for the period from 2020 to 2050.

«We know that urate has neuroprotective properties in animal models, and an unusual convergence of human studies suggested its possible use as a disease - modifying strategy in Parkinson's; so the positive results of this trial are very encouraging.»

By coupling a machine learning model with a patient's pulse data, they are able to measure a key risk factor for cardiovascular diseases and arterial stiffness, using just a smart phone.

She and her colleagues will be exploring the role of YY1 further, using clinical samples as well as mouse models, to look at the protein in diseases like lupus to deepen their understanding of how autoimmunity could result from the «escape» of immune genes from X chromosome inactivation.

Bocinsky and d'Alpoim Guedes are using the modeling technique to identify little - used or in some cases completely forgotten crops that could be useful in areas where warmer weather, drought and disease impact food supply.

We can use this model to study how the skin barrier develops normally, how the barrier is impaired in different diseases and how we can stimulate its repair and recovery.»

Now that the team has generated the tools necessary to rapidly manipulate killifish, the model organism can be used to screen for genes and drugs that slow or reverse aging and age - related diseases.

Stem cell models, derived from healthy or diseased cells, are also being developed for use in drug efficacy and toxicity testing.

This is particularly important as it indicates the method can be used in a variety of cell types to create disease models and contribute to the discovery of new disease - specific therapeutics.

Using CRISPR / Cas9, the Hamon Center team was able to correct the genetic defect in a mouse model of DMD and thus prevent the development of features of the disease, which in boys causes progressive muscle weakness and degeneration, often along with breathing and heart complications.

Most animal studies of the disease are conducted with laboratory mice that have been genetically engineered and bred to model ALS, but for this research, investigators used rats with ALS because they more accurately portray the disease's variable course in humans.

«This computational model might be used to predict other life - threatening episodes of diseases,» Chen said.

hiSCs were used to model adrenal diseases in a dish and provided a platform to test interventions for new personalised treatments.

«TB is a complex disease and modelling it is difficult but we've successfully used our model to replicate real world situations and are confident that it can be used to predict the effects of various changes in the way we tackle the disease.»

«One idea is to develop disease models that can use existing climate models to predict where these vectors will show up due to climate variability,» she said.

This human - agent model of disease dynamics can then be used to provide reproducible empirical analyses, yielding greater insights into the behavioural reactions and individual responses of people threatened by outbreaks of disease.

In this latest research, Mohan and his colleagues present new findings that detail the use of a synthetic, plant - derived compound — abbreviated CDDO — that was shown to effectively suppress the multiple steps of lupus development in murine models, including the onset of kidney disease.

Mardinoglu says the team's network modeling approach, which relied on data from the Sweden - based Human Protein Atlas project and The Genotype - Tissue Expression (GTEx) project consortia, can be used in the identification of drug targets and eventually in the development of efficient strategies for treating a number of chronic liver diseases.

First, the researchers used mice that had been genetically modified to produce excess amounts of the human version of ß amyloid — a common Alzheimer's disease model.

One BSL - 4 lab in Harbin is already awaiting accreditation; the next two are expected to be in Beijing and Kunming, the latter focused on using monkey models to study disease.

DNA - In CRISPR is an innovative transfection reagent that simplifies and accelerates genome editing using large plasmids and difficult - to - transfect cells for life science researchers generating disease models.

Using a combination of cell - based and mouse models, the researchers showed that the recently - evolved mycobacteria were more virulent, likely to cause more serious disease in patients.

Eggan has also been itching to use cloning technology to create embryonic stem cells that could be used to model the development of various diseases, especially diabetes and ALS.

Using experimental models and state - of - the - art technology, the scientists found that switching off this protein leads to better control of glucose production from the liver, revealing a potential new target that may be used to treat type 2 diabetes and other metabolic diseases.

Animal models are often used to replicate human disease; the relevance and similarity between animal models of joint disease and human osteoarthritis has not been fully evaluated.

«Using the fruit fly as a model [for a human disease] is extremely exciting,» he adds.

Perlmutter researchers used a mouse model of PDA, a disease that is usually fatal in patients within five years of diagnosis.

However, research at The University of Manchester using higher doses of Genistein Alygone in the mouse model of Sanfilippo Disease has shown that this is effective in reducing neurodegeneration2, 3.

It could be used to diagnose almost any human disease, sometimes before symptoms appear, help identify new drugs, and even change the way we use animal models to understand disease.