There are at least three unique challenges hampering brain disease management: relative inaccessibility,
disease onset often preceding the onset of clinical symptoms by many years and overlap between clinical and pathological symptoms that makes accurate disease identification often difficult.
Not exact matches
These newer studies are beginning to uncover the reasons why men are much more susceptible to neurodegenerative
diseases like Parkinson's and ALS; why autism, dyslexia, stuttering and early
onset schizophrenia are three to four times more prevalent in boys; and why attention deficit hyperactivity disorder is diagnosed 10 times more
often in boys.
Olfactory dysfunction is commonly associated with neurodegenerative
diseases, such as Alzheimer's and Parkinson's
disease, and is
often a measurable sign of these
diseases prior to the
onset of their cardinal symptoms.
«It is well recognized that food intake is implicated in many chronic health issues including obesity, diabetes and heart
disease, and diet is
often a target of treatment to prevent the
onset of these conditions,» commented the researchers Alyssa Lundahl and Timothy D Nelson of the University of Nebraska - Lincoln, USA.
Reykjavik, ICELAND, and Basel, SWITZERLAND, August 18, 2000 — deCODE genetics (Nasdaq / Easdaq: DCGN) and F.Hoffmann - La Roche announced today that scientists at deCODE have successfully mapped a novel gene that contributes to the occurrence of the common form of Alzheimer's
disease (
often referred to as late -
onset Alzheimer's).
Our first liver therapeutic development program is for methylmalonic acidemia (MMA), a serious and
often life - threatening rare liver
disease; it is primarily a pediatric
disease with
onset in early infancy.
«People with Parkinson's
disease often show signs of depression before the
onset of significant movement problems, so it's likely that the neural imbalance in Parkinson's is also responsible for some behavioral changes associated with the
disease,» said Dr. Kreitzer, who is also an assistant professor of physiology at the University of California, San Francisco, with which Gladstone is affiliated.
What's particularly worrying is sufferers may not be aware they have the
disease, as the
onset is
often slow and can show little symptoms.
Traditional bloodwork, such as standard lipid panels or glucose testing,
often fails to adequately capture a patient's health risks before the
onset of cardiovascular
disease, diabetes, rheumatic states, and other chronic conditions.
Fibrocystic breast
disease often becomes painful and the benign tumors swell with the
onset of menstruation.
Because hemangiosarcoma tumors most
often in develop in internal organs, frequently, there are few or no obvious symptoms before the
onset of severe clinical signs of
disease.
Dogs and Cats age much more quickly than humans and the gradual
onset of
disease in seemingly healthy pets
often goes unnoticed.
Most
often, the
disease is recognized by the
onset of a heart murmur, which can be recognized during a routine physical exam.
Acquired, or adult
onset heart
disease in cats
often occurs in middle - aged to older animals due to wear and tear on the heart structures, but can also result from an injury or infection
Hyperthyroid cats are rarely presented to the veterinarian for behavioral signs, Perhaps because aggression is primarily wen when the cat is restrained, we as a profession are more likely to experience this aspect of the
disease than the cats» owners, Treating the underlying thyroid problem generally resolves the behavioral problems however, and because
onset is
often insidious, it is only after the endocrine imbalance has been addressed that the owners appreciate the deterioration in their animal's behavior.
Since changes made by Cushing's
disease are quite gradual in
onset and are
often believed to be a result of simple aging, many dogs are not diagnosed until the
disease is advanced.
Juvenile
onset carries a fair to good prognosis, since the flawed immune system is usually age related, and clinical
disease will
often abate with age.
This wide range in
onset has made the
disease extremely difficult to predict or eliminate; affected dogs are
often bred before the owner realizes they will develop the
disease.
Clinically affected dogs are
often young (3 - 18 months of age) and present with poor weight gain, progressive peripheral neuropathy including ataxia, leg crossing, tremors and paresis which worsens with exercise.Behavioral changes, blindness, dementia, anorexia, cachexia, urinary incontinence and muscle weakness affecting all four limbs are usually present in terminal stages of the
disease with death occurring 2 - 6 months after
onset of clinical signs, necessitating euthanasia.
Often dental
disease is a gradual
onset, and some people mistake it as their pet getting «grumpy» in old age.
However, much like human
diseases, the gradual
onset of symptoms may
often go unnoticed.
The Sudden
onset of the
disease often makes an owner think that a cat has been poisoned.