The company is developing a portfolio consisting of four advanced product candidates, including pimavanserin, which is in Phase III development for the treatment of Parkinson's
disease psychosis.
At issue is whether previously unknown risks have been found for Nuplazid, which treats Parkinson's
disease psychosis.
Not exact matches
Nuplazid, which treats
psychosis associated with Parkinson's
disease, has been scrutinized for reports people dying while taking it.
Of the participants, over one - third reported a medical history that included some form of psychiatric
disease, including depression and even
psychosis.
Postpartum depression left untreated for weeks can cause the
disease to worsen, possibly developing into postpartum
psychosis which can require quick and immediate treatment.
«Pimavanserin: Relief from
psychosis in dementia, without devastating side - effects: A new kind of antipsychotic has been found to relieve terrifying and disturbing symptoms suffered by millions of people with Alzheimer's
disease worldwide.»
Up to 5 % of alcoholics in the United States develop Korsakoff's
psychosis, a chronic
disease that wipes out memories and can prevent new ones from forming.
The term «schizophrenia,» with its connotation of hopeless chronic brain
disease, should be dropped and replaced with something like «
psychosis spectrum syndrome,» argues a professor of psychiatry in The BMJ today.
Several trials have shown that CBT can reduce the risk of developing
psychosis by about 50 % in the following year, Heinssen says, though it's not clear whether treatment prevents or delays
disease.
An alteration in the neuregulin - 1 gene — a single change in one letter of the DNA code for the protein — has been found in families with schizophrenia and linked to late - onset Alzheimer's
disease with
psychosis.
When asked about the ethics of offering a drug to people who may never get the
disease it's designed to prevent, Michael Sand, the Boehringer scientist overseeing the clinical trial, acknowledges that
psychosis risk prediction is far from perfect.
Moreover, males with
psychosis are more likely to die prematurely due to cardiovascular
disease also.
Understanding and overcoming these barriers could be an important strategy to help people with
psychosis be more active, and potentially to reduce their risk of cardiovascular
disease.»
Less than a decade ago, anti-NMDA receptor encephalitis was first identified, a
disease characterized by inflammation of the brain that causes acute psychiatric symptoms including
psychosis.
Professor Clive Ballard from the Wolfson Centre for Age - Related Diseases at the IoPPN, King's College London, said: «Our findings clearly indicate serious risks associated with antipsychotics and highlight the need for greater caution in treating
psychosis in Parkinson's
disease.
Studies reveal that subtle indications of the
disease can be identified long before full - blown
psychosis develops.
Complementing its extensive capabilities, PsychoGenics offers a variety of validated mouse models including in - licensed transgenic models that support research in areas such as Alzheimer's
disease, Huntington's
disease, Parkinson's
disease, Autism spectrum disorders,
psychosis / schizophrenia, Spinal Muscular Atrophy (SMA), muscular dystrophy and other muscle disorders.
PsychoGenics works with pharmaceutical and biotechnology companies, academic institutions and not - for - profit research foundations to address such major neurological disorders as: ALS, Huntington's
Disease, anxiety, cognitive impairment, depression,
psychosis / schizophrenia and SMA.
As the
disease continues to progress, people with CJD may experience hallucinations,
psychosis, deterioration of coordination, involuntary movements, very weak arms and legs, poor ability to swallow and speak, and further mental impairments.
These results suggest that the serotoninergic system may be not involved in the pathogenesis of depressive symptoms in AD patients, and it may be involved in other aspects of
disease pathophysiology like cognitive symptoms and
psychosis.
A dosage adjustment is made when the patient is an elder one, suffers from agitation or
psychosis, has any form cardiovascular
disease or has already experienced a long standing and severe form of hypothyroidism.
Quite a lot of research has been done in this area, where gluteomorphins have been found in the urine of patients with schizophrenia, autism, ADHD, postpartum
psychosis, epilepsy, Down's syndrome, depression, and autoimmune
diseases like rheumatoid arthritis.
Markers of gluten sensitivity and celiac
disease in recent - onset
psychosis and multi-episode schizophrenia.
Its deficiency, which is often masked by folic acid, may lead to neurological damage and trigger symptoms of various
diseases including multiple sclerosis (MS), depression,
psychosis, or Parkinson's
disease.
Patients had to fulfil the following criteria: a diagnosis of schizophrenia, schizoaffective
psychosis, or delusional disorder according to criteria from the Diagnostic and Statistical Manual of Mental Disorders, 3rd edition, revised11; no evidence of organic brain
disease; substance abuse not identified as the primary problem; age between 18 and 65 years; presence of persistent hallucinations or delusions, or both, for a minimum of 6 months and at least 1 month of stabilisation if they had experienced an exacerbation during this period; stable medication; no psychological or family intervention; their responsible medical officer had given permission for them to enter the study; no serious threat of violence towards the assessors; and they had given informed consent to participate.