In conclusion, histone modifier genes indicate clinical progression of PTCL - NOS and may represent a group of actionable biomarkers of
this disease subtype.
What's more — in the absence of information on the underlying molecular mechanisms of her particular case — that patient will likely end up taking a one - size - fits - all pill rather than a drug tailored for her unique
disease subtype.
«In this study we've shown five distinct ways — by quantifying tumor burden, identifying
disease subtype, cataloging mutations, predicting transformation and providing early warnings of recurrence — that circulating tumor DNA can yield potentially clinically useful information,» said Diehn.
A team of researchers led by UC San Francisco scientists has identified a new drug target for triple - negative breast cancer, an aggressive
disease subtype that has the poorest outcomes and accounts for as many as one in five cases.
An analysis based on
disease subtype showed that ibrutinib produced complete or partial responses in 37 percent (14 of 38) of patients with ABC DLBCL but only 5 percent (1 of 20) of patients with GCB DLBCL.
Nearly half of all blood cancer cases are lymphomas, or cancers of the lymphatic system, of which there are numerous unique
disease subtypes.
On the other hand, in a given tissue, the same tRNA sequences will produce different fragments in health and disease and across
disease subtypes.
«There is a pressing need in psychiatry to establish biologically based
disease subtypes, which might allow for more specific diagnosis and effective intervention,» says Dr Brilot.
Ongoing research includes efforts to identify more of the mutant genes and proteins that cause the various
disease subtypes.
By characterizing the role of gene mutations and copy number variations in a number of complement associated disorders, including kidney diseases, such as HUS (Hemolytic Uremic Syndrome), DDD (Dense Deposit Disease) or AMD (Age Related Macular Degeneration) the group has identified new
disease subtypes of this severe kidney diseases.
For example, in addition to asymmetric distribution of amyloid beta, which has been reported, the differences could reflect
disease subtypes that affect hemispheres differently.»
Ongoing research includes efforts to identify more of the mutant genes and proteins that cause the various
disease subtypes, efforts to discover the mechanisms of nerve degeneration and muscle atrophy with the hope of developing interventions to stop or slow down these debilitating processes, and efforts to find therapies to reverse nerve degeneration and muscle atrophy.
Not exact matches
He conducted his postdoctoral research at Brigham and Women's Hospital / Harvard Medical School, where he researched the role of the Wnt signaling pathway in mouse models of kidney
disease, and was part of a team that discovered a stem cell
subtype responsible for solid organ fibrosis.
Vaccines against one
subtype won't protect you against the others, says Harold Margolis, head of the dengue branch of the Centers for
Disease Control and Prevention (CDC) in San Juan, Puerto Rico.
«Suppressing a progenitor from creating the
subtype of dendritic cells implicated in causing lupus, for example, could be an efficient way of treating autoimmune
diseases while minimising the impact on the rest of the immune system.
Professor Nigel Bundred, from The University of Manchester and University Hospital of South Manchester NHS Foundation Trust, who led the study, said: «We know that different
subtypes of invasive breast cancer have different levels of
disease recurrence.
In 2009, a new strain of H1N1 caused what the Centers for
Disease Control and Prevention called «the first influenza pandemic in more than 40 years,» testament to a long - known influenza
subtype evolving into a new threat.
«Central America «kissing bug» carries two main
subtypes of Chagas
disease parasite.»
«The next step in understanding sleep apnea in the future will be to dissect different
subtypes of sleep apnea, likely defined by distinct pathophysiological mechanisms which may underlie different outcomes and predisposition to comorbidities,» Cavadas says, «As human life expectancy increases, delaying the onset of age - related
diseases becomes critical to our society.»
A recent study by researchers from the Manchester Cancer Research Centre, published in the journal Annals of Oncology, has explored potential
subtypes of DCIS and whether these
subtypes relate to
disease recurrence.
«Our study examined the effect of folic acid food fortification on each specific
subtype of congenital heart
disease based on the Canadian experience before and after food fortification was made mandatory in 1998,» said K.S. Joseph, M.D., Ph.D., the study's senior author and professor in the Department of Obstetrics and Gynecology and the School of Population and Public Health at the University of British Columbia in Vancouver, Canada.
A clinical trial has shown that patients with a specific molecular
subtype of diffuse large B - cell lymphoma (DLBCL) are more likely to respond to the drug ibrutinib (Imbruvica) than patients with another molecular
subtype of the
disease.
The novel H1N1 virus accounts for more than 99 % of the isolates
subtyped since 30 August in the United States, Nancy Cox, head of the influenza division at the U.S. Centers for
Disease Control and Prevention told ScienceInsider in an e-mail 10 days ago.
Rao and the research team found that it plays an important role in the development of the MLL - rearranged
subtype of leukemia by regulating various RNA messages that contribute to the
disease.
The team therefore analyzed the case history of 890 breast cancer patients and found that low Numb - 1 and -2 levels correlated with an increased risk of aggressive, metastatic
disease, particularly for the luminal
subtype of breast cancers, which tend to retain a normal, functional copy of the p53 gene.
This is important, he added, because this technique is increasingly used for classifying
diseases and their
subtypes, understanding gene expression changes during development and tracking the progression of cancer.
«Forty years ago, very little was known about breast cancer
disease biology — such as
subtypes, differences in radio - sensitivities, radio - resistances, local recurrence and in metastatic potential,» explains Bedrosian, the study's senior author.
There are four different
subtypes of the dengue virus, individuals can be infected multiple times with different viral
subtypes, and re-infection is associated with an increased risk for severe
disease.
When the researchers matched this data with clinical outcomes for more than 4,600 patient specimens in medical databases, they found these
subtypes were associated with different levels of
disease progression.
Ovarian cancer researchers have identified a protein biomarker expressed on the surface of tumour cells in high - grade serous ovarian cancer, the most common and lethal
subtype of the
disease.
In other
disease areas, the Parkinson's
disease map and the Atlas of Cancer Signalling Network, have already begun the process of integrating knowledge about the involved mechanisms in order to understand the different
subtypes of these
diseases.
Dr Alexander Mazein, lead author of the study from the European Institute for Systems Biology and Medicine, commented: «In - depth understanding of asthma means redefinition of asthma
subtypes based on the mechanisms that lead to the development of the
disease.
«In IBD therapy, this is a step toward precision medicine — to be able to clinically and biologically characterize a
subtype of
disease and then select the medicine that would best fit the patient with this type of inflammation,» Dr. Longman added.
This allows researchers to identify all of the components that play a role in a
disease, with the ultimate aim of understanding the different
subtypes of different
diseases and being able to better target therapies and treatments.
«We're still early in the study of androgen receptor in breast cancer and already scientists are divvying up the
disease to say, for example, that only the high AR expressing
subtype should be treated with anti-androgen receptor therapies,» Barton says.
This hybrid gene forms from two previously separate genes and only occurs in a new
subtype of this
disease.
Historically, medulloblastoma has been treated as a single
disease even though researchers at St. Jude and elsewhere showed that patient outcomes vary widely based on their tumor
subtype.
A subgroup of patients with NAFLD progresses to the inflammatory
subtype of the
disease called non-alcoholic steatohepatitis (NASH).
The
disease includes four biologically and clinically distinct
subtypes, of which Group 4 is the most common.
In the era of personalized cancer therapy, patients with TNBC remain at considerably higher risk of relapse and death than patients with other breast cancer
subtypes, due to the aggressive nature of TNBC and the lack of newer targeted therapies for the
disease.
These
subtype data are then combined with a standard pathology variable to deliver a «risk of recurrence» score that predicts the likelihood of that patient's
disease returning within the next 10 years.
Tumors in this
subtype «are associated with relatively indolent
disease, are cured by surgery, and almost never recur,» Swanton says.
Members of the section have discovered three of the nine genetic
subtypes of HPS, and serve as authorities on the clinical and basic research aspects of this group of
diseases.
The breakdown by intrinsic [gene expression]
subtype is generally representative of the
disease incidence as a whole:
We've also learned, he says, that cancer is not one
disease but many
subtypes, so there will never be a single penicillin - like cure.
In summary, our findings suggest that the specific genetic
subtypes of B. burgdorferi sensu stricto influence
disease pathogenesis.
This study suggests that a major determinant of the risk for hematogenous dissemination of B. burgdorferi in Lyme
disease patients with erythema migrans is the genetic
subtype of the infecting strain in the skin.
Doctors are already using drugs, such as Herceptin, that specifically target malfunctioning genetic pathways in tumors, but no such therapies are currently available for certain aggressive forms of the
disease, such as the triple negative
subtype.
Gary P. Wormser, Dionysios Liveris, John Nowakowski, Robert B. Nadelman, L. Frank Cavaliere, Donna McKenna, Diane Holmgren, Ira Schwartz; Association of Specific
Subtypes of Borrelia burgdorferi with Hematogenous Dissemination in Early Lyme
Disease, The Journal of Infectious Diseases, Volume 180, Issue 3, 1 September 1999, Pages 720 — 725, https://doi.org/10.1086/314922
Mucosal melanoma is a unique
disease that requires clinical considerations distinct from other melanoma
subtypes.