Sentences with phrase «disease subtypes»
"Disease subtypes" refers to different categories or types of a particular disease. These subtypes may vary in terms of symptoms, causes, or the way they affect the body. It helps doctors and researchers understand and classify diseases more accurately to develop appropriate treatments and interventions. Full definition
Nearly half of all blood cancer cases are lymphomas, or cancers of the lymphatic system, of which there are numerous unique disease subtypes.
sciencedaily.com
Other goals are to identify which drugs work best for which cancer patients, using novel biomarkers to describe more precisely than before the match between disease subtypes and treatments.
Ongoing research includes efforts to identify more of the mutant genes and proteins that cause the various disease subtypes.
«There is a pressing need in psychiatry to establish biologically based disease subtypes, which might allow for more specific diagnosis and effective intervention,» says Dr Brilot.
«In this study we've shown five distinct ways — by quantifying tumor burden, identifying disease subtype, cataloging mutations, predicting transformation and providing early warnings of recurrence — that circulating tumor DNA can yield potentially clinically useful information,» said Diehn.
An analysis based on disease subtype showed that ibrutinib produced complete or partial responses in 37 percent (14 of 38) of patients with ABC DLBCL but only 5 percent (1 of 20) of patients with GCB DLBCL.
On the other hand, in a given tissue, the same tRNA sequences will produce different fragments in health and disease and across disease subtypes.
A team of researchers led by UC San Francisco scientists has identified a new drug target for triple - negative breast cancer, an aggressive disease subtype that has the poorest outcomes and accounts for as many as one in five cases.
By characterizing the role of gene mutations and copy number variations in a number of complement associated disorders, including kidney diseases, such as HUS (Hemolytic Uremic Syndrome), DDD (Dense Deposit Disease) or AMD (Age Related Macular Degeneration) the group has identified new disease subtypes of this severe kidney diseases.
For example, in addition to asymmetric distribution of amyloid beta, which has been reported, the differences could reflect disease subtypes that affect hemispheres differently.»
What's more — in the absence of information on the underlying molecular mechanisms of her particular case — that patient will likely end up taking a one - size - fits - all pill rather than a drug tailored for her unique disease subtype.
Notably, the team also found that these fragment attributes change between tissues, between healthy individuals and patients, and between disease subtypes.
Ongoing research includes efforts to identify more of the mutant genes and proteins that cause the various disease subtypes, efforts to discover the mechanisms of nerve degeneration and muscle atrophy with the hope of developing interventions to stop or slow down these debilitating processes, and efforts to find therapies to reverse nerve degeneration and muscle atrophy.
In conclusion, histone modifier genes indicate clinical progression of PTCL - NOS and may represent a group of actionable biomarkers of this disease subtype.