Sentences with phrase «disease than mice»

They found that the mice developed earlier and more severe disease than mice that had normal Tob1 expression in all cells including CD4 +.

An accelerated progression may show up in clinical trials in human males, who live longer with the disease than mice.

Not exact matches

«We don't know if the observed reversibility of the disease symptoms as observed in the mouse,» he says, «exists in humans who have a much longer period of pre - and post-natal brain development than mice — months and years in humans, weeks in mice.»

Among mice that had antibodies, i.e., during antibody - enhanced infection, the researchers found that the addition of saliva extract caused more severe disease than virus alone.

The behavioral tests used here modeled one dimension of the disease — an inability to experience pleasure from normal activities — but not others, such as stress and anxiety, and probably tap into different brain mechanisms in mice than in humans, he says.

With no more than a change in diet, laboratory agouti mice (left) were prompted to give birth to young (right) that differed markedly in appearance and disease susceptibility.

When the mice were just four months old — well before they showed symptoms of the disease — their synaptic mitochondria had accumulated approximately five times more amyloid protein than nonsynaptic mitochondria had.

«What we found was, if we block mGluR5, which is the glutamate receptor we're interested in, the mice become hyper locomotive so they become able to move better than wild type mice suggesting glutamate receptors might be a good target for treating movement disorders such as Parkinson's disease.

A dye used for more than a century to stain autopsied brain tissue can prevent the devastating effects of Huntington's disease in mice, new research shows.

The mice, described in this month's issue of Nature Genetics, also may provide a quick way to screen potential drugs for the disease, a disabling condition that afflicts more than a third of U.S. women over the age of 60.

The vaccine slowed the progression of prion disease in the remaining 70 % of the experimental mice, allowing them to live longer than control mice, which did not receive the vaccine and died within about 200 days following infection.

Once the microglia were mobilized in mouse models of Alzheimer's disease, the researchers observed a more than 60 percent reduction in amyloid beta in the brain.

Furthermore, more than 75 % of mice infected with virus bearing the normal protein developed severe corneal autoimmune disease, whereas fewer than 20 % of mice infected with mutant virus did, and their symptoms were barely detectable.

The new study — published October 18, 2016 in the journal Molecular Psychiatry — combined genetic analysis of more than 9,000 human psychiatric patients with brain imaging, electrophysiology, and pharmacological experiments in mutant mice to suggest that mutations in the gene DIXDC1 may act as a general risk factor for psychiatric disease by interfering with the way the brain regulates connections between neurons.

Half of the mice studied, belonging to a genetic line that suffers a form of Crohn's disease were more affected than the remaining half of mice, which belong to a healthy mouse line.

«The disease progression was much faster in the crossbred mice than in the standard mice,» Connor said.

«The dog has a retina very similar to ours, much more so than mice, so when you want to bring a visual therapy to the clinic, you want to first show that it works in a large animal model of the disease,» said lead researcher Ehud Isacoff, professor of molecular and cell biology at UC Berkeley.

Mice bred to carry a gene variant found in a third of ALS patients have a faster disease progression and die sooner than mice with the standard genetic model of the disease, according to Penn State College of Medicine researchMice bred to carry a gene variant found in a third of ALS patients have a faster disease progression and die sooner than mice with the standard genetic model of the disease, according to Penn State College of Medicine researchmice with the standard genetic model of the disease, according to Penn State College of Medicine researchers.

With the risk for obesity - associated diseases significantly higher for men than women, researchers compared how mice from each sex reacted to high - fat diets.

Lynch and the team, however, reasoned that a model that mirrored the slowly progressive nature of the disease might be more valid than the rapidly progressive mouse models more commonly used.

His symptoms may come closer to mimicking the human disease than most mouse models of mental illness, because the gene involved has such a powerful effect.

The authors also found abnormalities in the subthalamic nucleus occur earlier than in other brain regions, and that subthalamic nucleus nerve cells progressively degenerate as the mice age, mirroring the human pathology of Huntington's disease.

Experiments on mice and on heart cells obtained from infants born with congenital heart disease suggest that neuregulin 1, a human growth factor, can put infant heart cells on a path that mimics normal growth rather than stalling out.

Using a model of Parkinson's disease in which the toxin MPTP, made famous in book «The Case of the Frozen Addicts,» induces Parkinson's - like symptoms in humans and mice, Dr. Smeyne showed that mice infected with H1N1, even long after the initial infection, had more severe Parkinson's symptoms than those who had not been infected with the flu.

SIGMAR1 deficiency accelerated disease onset of SOD1 - ALS mice by more than 20 %.

Sinclair's lab is now working on developing what he calls a possible «supermouse» with elevated levels of NAMPT to see if it lives longer and is more disease - resistant than normal mice.

The Weill Cornell researchers studied more than 500 Crohn's disease patients and found that those who carry a homozygous mutation in the CX3CR1 gene have a reduced gut antifungal response much like that seen in the mice lacking CX3CR1 + phagocytes.

So when Drake and his colleagues measured the RNA levels — a direct link to how much of a gene is being produced — in the genes of 334 mice, he didn't expect to find more than a few variations that might help explain why males and females have such different rates of cardiovascular disease and diabetes or why they react differently to certain drugs.

In the study, mice given a lethal dose of dengue virus less than a week after receiving the protective DMAb were completely protected from lethal disease — significantly more rapid than vaccine - driven protection, which can take weeks to months to reach peak efficacy levels.

Specifically, rod - mediated inner retinal responses to dim light flashes were faster in diseased mice than in their wild - type controls.

The mice that were fed a calorie - restricted diet, mainly by a reduction in their carbohydrate intake, over a period of six months, had fewer disease symptoms than their normal - diet counterparts.

«Two is better than one to improve brain function in Alzheimer's disease mouse model.»

REG3G - deficient mice also developed more severe alcoholic liver disease than normal mice.

Using two complementary approaches to reduce the deposits of amyloid - beta in the brain rather than either approach alone improved spatial navigation and memory in a mouse model of Alzheimer's disease.

In mice, the dose required for contraception was 10 times lower than that required for treating Gaucher's disease patients.

«We don't yet understand why mice that develop severe inflammation express about 20 times higher levels of CD209a than mice that do not develop severe disease, and we don't yet know about the role of DC - SIGN in human schistosomiasis.

The researchers found that bacteria forming part of a cluster were more likely to be taken up by human cells and to survive in them than the microbes without close relatives; the cluster strains also caused more severe disease in mice.

If sufficient 1,25 - dihydroxyvitamin D is produced, it may exert paracrine effects on surrounding T lymphocytes, thereby regulating the tissue - specific immune responses.10 Some support for this hypothesis comes from recent experiments showing that mice fed diets high in vitamin D had significantly fewer clinical and pathological signs of EAE than mice fed a vitamin D — deficient diet.37 Central nervous system levels of 1,25 - dihydroxyvitamin D, but not blood levels, were higher in supplemented mice than in vitamin D — deficient mice and correlated inversely with disease severity.

To better understand this complex tissues and its functions — and the diseases that affect it — a multicenter team led by researchers at the Broad Institute of MIT and Harvard and Massachusetts General Hospital has released a census of the cells that make up the lining of the small intestine, using gene expression profiles of more than 53,000 individual cells from the mouse gut or gut organoid models.

They do not appear to live any longer than the rest of us, which is a caution for anyone extrapolating effects from mice, and have a variety of medical issues associated with their form of dwarfism, but may be resistant to some forms of age - related disease.

«Because scientists can selectively switch off genes in mice, more will be learnt about human disease from the mouse genome than from the human genome.

He notes that though ticks carry the disease, its real reservoir in the wild is white - footed mice, and their reproductive behavior is more susceptible to gene drive than ticks.

The CRISPR / Cas technology applied to mouse genetic engineering could quickly advance scientific understanding of disease mechanisms by allowing researchers to ask complex questions and find answers much faster than with traditional gene targeting approaches.

It should be noted, however, that while a study on senescent cell ablation in genetically normal mice would provide at least some evidence on the effect of senescent cells (and their ablation) on promoting cancer, even such a study would likely show less effect than could be anticipated in a large mammal model, since even normally - aging mice rarely suffer metastatic disease to the extent of aging humans, as sheer primary tumor volume is generally sufficient to be fatal to mice.

There are lots of different HD mice available, and because every case of HD is caused by the same basic genetic mutation, it may be that «our» mice will turn out to be better than those of other diseases, at predicting success in human patients.

Results showed the first two groups didn't develop PCOS, unlike the mice in the control group, whereas the test subjects with ovary ARs still contracted the disease, albeit at a lower rate than the normal mice.

It creates customisable and high - scale mouse models of human disease or displaying an abnormality (KI, KO mouse models) and it provides a complete phenotyping characterisation of the immune system by polychromatic and mass cytometry measuring more than 50 simultaneous quantitative parameters in standardised conditions.

Vicky Robinson, of NC3Rs, which campaigns to reduce use of animals, said: «We can't assume a transgenic marmoset will be better for disease research than, for example, a transgenic mouse.

These kind of mice are an extraordinary resource for modeling human disease; for instance, research has found that mice that are genetically mutated to carry the BRCA1 gene (a human breast cancer gene) behave more similarly to human cancer patients than those mice who have had a tumor physically transplanted in.

«Still, as in humans,» says Reinholdt, «the success rate for Mendelian disease gene discovery in the mouse is only slightly better than 50 percent.»