Sentences with phrase «disease with environmental factors»

In the last 20 years, people have been so focused on linking disease with environmental factors like chemicals and pollution.

Not exact matches

Important factors that could cause actual results to differ materially from those reflected in such forward - looking statements and that should be considered in evaluating our outlook include, but are not limited to, the following: 1) our ability to continue to grow our business and execute our growth strategy, including the timing, execution, and profitability of new and maturing programs; 2) our ability to perform our obligations under our new and maturing commercial, business aircraft, and military development programs, and the related recurring production; 3) our ability to accurately estimate and manage performance, cost, and revenue under our contracts, including our ability to achieve certain cost reductions with respect to the B787 program; 4) margin pressures and the potential for additional forward losses on new and maturing programs; 5) our ability to accommodate, and the cost of accommodating, announced increases in the build rates of certain aircraft; 6) the effect on aircraft demand and build rates of changing customer preferences for business aircraft, including the effect of global economic conditions on the business aircraft market and expanding conflicts or political unrest in the Middle East or Asia; 7) customer cancellations or deferrals as a result of global economic uncertainty or otherwise; 8) the effect of economic conditions in the industries and markets in which we operate in the U.S. and globally and any changes therein, including fluctuations in foreign currency exchange rates; 9) the success and timely execution of key milestones such as the receipt of necessary regulatory approvals, including our ability to obtain in a timely fashion any required regulatory or other third party approvals for the consummation of our announced acquisition of Asco, and customer adherence to their announced schedules; 10) our ability to successfully negotiate, or re-negotiate, future pricing under our supply agreements with Boeing and our other customers; 11) our ability to enter into profitable supply arrangements with additional customers; 12) the ability of all parties to satisfy their performance requirements under existing supply contracts with our two major customers, Boeing and Airbus, and other customers, and the risk of nonpayment by such customers; 13) any adverse impact on Boeing's and Airbus» production of aircraft resulting from cancellations, deferrals, or reduced orders by their customers or from labor disputes, domestic or international hostilities, or acts of terrorism; 14) any adverse impact on the demand for air travel or our operations from the outbreak of diseases or epidemic or pandemic outbreaks; 15) our ability to avoid or recover from cyber-based or other security attacks, information technology failures, or other disruptions; 16) returns on pension plan assets and the impact of future discount rate changes on pension obligations; 17) our ability to borrow additional funds or refinance debt, including our ability to obtain the debt to finance the purchase price for our announced acquisition of Asco on favorable terms or at all; 18) competition from commercial aerospace original equipment manufacturers and other aerostructures suppliers; 19) the effect of governmental laws, such as U.S. export control laws and U.S. and foreign anti-bribery laws such as the Foreign Corrupt Practices Act and the United Kingdom Bribery Act, and environmental laws and agency regulations, both in the U.S. and abroad; 20) the effect of changes in tax law, such as the effect of The Tax Cuts and Jobs Act (the «TCJA») that was enacted on December 22, 2017, and changes to the interpretations of or guidance related thereto, and the Company's ability to accurately calculate and estimate the effect of such changes; 21) any reduction in our credit ratings; 22) our dependence on our suppliers, as well as the cost and availability of raw materials and purchased components; 23) our ability to recruit and retain a critical mass of highly - skilled employees and our relationships with the unions representing many of our employees; 24) spending by the U.S. and other governments on defense; 25) the possibility that our cash flows and our credit facility may not be adequate for our additional capital needs or for payment of interest on, and principal of, our indebtedness; 26) our exposure under our revolving credit facility to higher interest payments should interest rates increase substantially; 27) the effectiveness of any interest rate hedging programs; 28) the effectiveness of our internal control over financial reporting; 29) the outcome or impact of ongoing or future litigation, claims, and regulatory actions; 30) exposure to potential product liability and warranty claims; 31) our ability to effectively assess, manage and integrate acquisitions that we pursue, including our ability to successfully integrate the Asco business and generate synergies and other cost savings; 32) our ability to consummate our announced acquisition of Asco in a timely matter while avoiding any unexpected costs, charges, expenses, adverse changes to business relationships and other business disruptions for ourselves and Asco as a result of the acquisition; 33) our ability to continue selling certain receivables through our supplier financing program; 34) the risks of doing business internationally, including fluctuations in foreign current exchange rates, impositions of tariffs or embargoes, compliance with foreign laws, and domestic and foreign government policies; and 35) our ability to complete the proposed accelerated stock repurchase plan, among other things.

The authors contend that the Parkinson's community must come together and focus its activism in support of: developing a better understand the environmental, genetic, and behavioral causes and risk factors for Parkinson's to help prevent its onset; increasing access to care — an estimated 40 percent of people with the disease in both the U.S. and Europe do not see a neurologist and the number is far greater in developing nations; advocating for increases in research funding for the disease; and lowering the cost of treatments — many patients in low - income countries do not have access to drugs that are both lifesaving and improve quality of life.

Researchers believe the disease may be up to 80 % genetic, with environmental or physiological factors accounting for the rest.

And even if such a demand existed, there was no evidence that genetic counseling could help patients with psychiatric disorders, which — like most of the more common diseases — are caused by a complex interplay of multiple genes and variants as well as environmental factors.

One difficulty in studying the genetics of common mental illnesses is that they are generally caused by environmental factors in combination with multiple gene variants, any one of which usually could not by itself cause disease.

However, Browning emphasized that obesity is a complex disease with many genetic and environmental factors playing important roles.

Because most cases of Parkinson's disease appear to be at least partially caused by environmental factors such as pesticide exposure, these findings support the approach that targeting α - synuclein could slow or stop the progression of Parkinson's in most people with the disease, said study lead author Jeff Bronstein, a professor of neurology and director of movement disorders at the David Geffen School of Medicine at UCLA.

Dozens of genetic variations act in concert with environmental factors to cause the debilitating neurological disease.

Researchers will identify participants in those studies with CFS and search records of their environmental exposures and archived blood samples for disease risk factors.

«Crohn's disease is a complex disorder with multiple genes and environmental factors involved, which disproportionally affects individuals of Ashkenazi Jewish ancestry,» explained lead researcher Inga Peter, Professor of Genetics and Genomic Sciences at the Icahn School of Medicine at Mount Sinai in New York City.

That points to an environmental culprit that may work in concert with genetic factors to drive this aggressive, fatal disease.

Fourth, disease network analysis ultimately provides a mechanistic basis for defining phenotypic differences among individuals with the same disease through consideration of unique genetic and environmental factors that govern intermediate phenotypes contributing to disease expression.

Even classical Mendelian disorders have different clinical phenotypes that are a consequence of polymorphic or mutant disease ‐ modifying genes and their interactions with environmental factors.

One of the many points they hope TEDDY clarifies is if or how these genetics along with environmental factors — like childhood infections or even what children eat — conspire to cause actual disease.

It involves a host of genetic, lifestyle and environmental factors, and is now known to comprise hundreds of diseases — each with unique features, driving forces and vulnerabilities to treatments.

While environmental factors play a role in developing T2D, it is also highly heritable — and the genetics involved are complex, with many genes contributing to disease risk.

Preclinical and clinical biomarkers must be discovered, and their interaction with environmental factors understood, to then be validated in order, among other purposes, to refine the characterisation of phenotypes in heterogeneous diseases and to tailor the treatment to individual patients (personalised therapy).

Genetic epidemiology is a discipline takes care of studying the role of genetic factors and their interaction with environmental factors in the aetiology of human disease.

Reading is a multifactorial process that is influenced by psychological, physiological, environmental, sociological and linguistic factors.1, 2 From an optometrist's perspective, a decrease in reading ability may be associated with poor visual acuity, unstable binocular vision, or ocular disease.3 It is therefore important that people with poor reading comprehension receive a comprehensive oculo - visual assessment.

Dr. Bailey - Wilson's research group seeks to understand the genetic factors that increase risk for various complex diseases and their interactions with environmental risk factors.

Moreover, risk factors may be different for different individuals - while one person may develop schizophrenia due largely to a strong family history of mental illness (e.g. a high level of genetic risk), someone else with much less genetic vulnerability may also develop the disease due to a more significant combination of prepregnancy factors, pregnancy stress, other prenatal factors, social stress, family stress or environmental factors that they experience during their childhood, teen or early adult years.

Research insights into the genes and environmental factors that play a role in the development of childhood diseases are leading to better ways to more accurately diagnose, treat and cure children with disease.

In a study in the Journal of Occupational and Environmental Medicine, people with more heart disease risk factors — including high blood pressure, high cholesterol, and diabetes — were also more likely to suffer from shoulder pain or rotator cuff injuries.

Our team will spend time with each person listening to their histories and looking into the interaction of environmental, genetic and lifestyle factors that influence long term health and complex, chronic disease.

Organizations such as The Environmental Working Group and Institute for Responsible Technology are leading the way with research that shows the serious health impacts on the body from the impact of genetically modified (GM) foods There are now multiple animal studies that link GMO's with damage to the GUT, with immune disregulation, inflammation, and an increase in allergies or factors that trigger autoimmune disease.

There are a series of environmental and lifestyle factors that are associated with particular autoimmune disease, and it is actually possible to control the symptoms of an autoimmune disease, if not the disease itself, by altering your habits so that you can adjust to a healthier way of living.

Celiac disease occurs from an interaction between genes, eating foods with gluten and other environmental factors, but the precise cause isn't known.

Our physicians spend time with their patients, listening to their histories, mapping their personal timeline, and looking at the interactions among genetic, environmental, and lifestyle factors that can influence long - term health and complex chronic disease.

Until the exact modifying environmental or genetic factor is determined, genetic testing remains the only reliable way to detect neurological disease associated with this mutation prior to death.

However, not every dog with two copies will get the disease because of the environmental component to autoimmune disease and quite possibly other genes and / or gene regulatory factors.

Various control schemes have been established to screen potential breeding candidates with the aim of orchestrating some genetic control over the disease [17] which would complement modification of environmental factors such as diet and weight management.

You need to also know their market and generic name, what kind of interactions they have with other medications, diseases, and environmental factors (tetracycline for example is photosensitive) and little facts like there's a limited number of antibiotics that you can give to pregnant women and what foods you can't eat if you're taking an antidepressant.