Sentences with phrase «diseased lung tissue»

«We have also tested this process in human cells taken from diseased lung tissue, and we see very similar results.»

Not exact matches

They were particularly interested in IL - 33, a gene linked to inflammation that is overexpressed in the lung tissue of asthmatics compared with people without the disease.

Interdisciplinary research at the University of Pennsylvania is showing how cells interact over long distances within fibrous tissue, like that associated with many diseases of the liver, lungs and other organs.

In lung biopsies and serum, they found that CHI3L1 levels are elevated in both tissue compartments in the outpatients with IPF and that the levels of CHI3L1 correlated with their disease progression.

Griffiths also notes that emphysema, a lung disease common in smokers, is marked by a loss of connective tissue and may be related to increased MMP - 1 levels.

In much of California, on the other hand, a witches» brew of pollutants cooked in the atmosphere can sear the delicate tissue lining the lungs and aggravate an astonishing array of other health problems, ranging from heart disease and lung cancer to dementia.

The density of healthy lung tissue will change more between the two images than the density of diseased lung, allowing researchers to create a three - dimensional «map» of the patient's lung function

SLE is a genetically complex chronic relapsing autoimmune disease characterised by inflammation that may affect different tissues, including the skin, joint linings, lungs, kidneys and other organs.

Compared with lung tissue of disease - free individuals, lung tissue from patients with pulmonary fibrosis had far fewer AEC2 cells, and those that remained were less able to renew themselves.

It is a progressive, fatal disease characterized by scarring deep in the lung tissue that leads to respiratory or heart failure, pneumonia, and pulmonary embolism.

A new study shows that restoring the lipids that help keep lung tissue flexible and inflated can help slow disease progression in laboratory models of pulmonary fibrosis.

A team led by infectious diseases researcher Charles Chiu of the University of California, San Francisco, analyzed lung tissue samples from the dead monkeys and identified a never - before - seen adenovirus, which they named titi monkey adenovirus (TMAdV).

Harvard Stem Cell Institute scientists at Brigham and Women's Hospital have found the cellular origin of the tissue scarring caused by organ damage associated with diabetes, lung disease, high blood pressure, kidney disease, and other conditions.

Fourth, the finding of intranuclear inclusions in diseased tissues, as well as direct visualization of adenoviral - like particles (TMAdV) in lung alveoli by electron microscopy (Figs. 1D - 2 to 1D - 4), support a primary role for TMAdV in the pathogenesis of tissue injury in affected monkeys.

To confirm the presence of virus in diseased tissues, we examined lung tissue from affected monkeys by transmission electron microscopy, revealing abundant icosahedral particles characteristic of adenovirus filling the alveoli (Fig. 1D - 4).

For more information regarding Bristol - Myers Squibb Clinical Trial participation, please visit www.BMSStudyConnect.com Inclusion Criteria: • Early stage IB - IIIA, operable non-small cell lung cancer, confirmed in tissue • Lung function capacity capable of tolerating the proposed lung surgery • Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 - 1 • Available tissue of primary lung tumor Exclusion Criteria: • Presence of locally advanced, inoperable or metastatic disease • Participants with active, known or suspected autoimmune disease • Prior treatment with any drug that targets T cell co-stimulations pathways (such as checkpoint inhibitors) Other protocol defined inclusion / exclusion criteria could alung cancer, confirmed in tissue • Lung function capacity capable of tolerating the proposed lung surgery • Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 - 1 • Available tissue of primary lung tumor Exclusion Criteria: • Presence of locally advanced, inoperable or metastatic disease • Participants with active, known or suspected autoimmune disease • Prior treatment with any drug that targets T cell co-stimulations pathways (such as checkpoint inhibitors) Other protocol defined inclusion / exclusion criteria could aLung function capacity capable of tolerating the proposed lung surgery • Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 - 1 • Available tissue of primary lung tumor Exclusion Criteria: • Presence of locally advanced, inoperable or metastatic disease • Participants with active, known or suspected autoimmune disease • Prior treatment with any drug that targets T cell co-stimulations pathways (such as checkpoint inhibitors) Other protocol defined inclusion / exclusion criteria could alung surgery • Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 - 1 • Available tissue of primary lung tumor Exclusion Criteria: • Presence of locally advanced, inoperable or metastatic disease • Participants with active, known or suspected autoimmune disease • Prior treatment with any drug that targets T cell co-stimulations pathways (such as checkpoint inhibitors) Other protocol defined inclusion / exclusion criteria could alung tumor Exclusion Criteria: • Presence of locally advanced, inoperable or metastatic disease • Participants with active, known or suspected autoimmune disease • Prior treatment with any drug that targets T cell co-stimulations pathways (such as checkpoint inhibitors) Other protocol defined inclusion / exclusion criteria could apply

Inclusion Criteria: • Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1 • Have histologically or cytologically confirmed advanced or metastatic non-small cell lung cancer (NSCLC)(Stage IIIb or greater) • Measurable disease, as defined by Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 • Known PD - L1 tumor status as determined by an immunohistochemistry (IHC) assay performed by the central laboratory on tissue obtained at Screening • A woman of childbearing potential must have a negative highly sensitive serum (beta - human chorionic gonadotropin [beta - hCG]-RRB- at Screening within 14 days prior to study drug administration Inclusion Criteria for Crossover: • Participants must have been randomized to Arm A of the study and had radiographic disease progression according to RECIST 1.1 • Participants must have a mandatory biopsy at the time of disease progression according to RECIST 1.1 prior to crossing over.

The Division of Pulmonary Medicine deals with the breath of life in all its aspects: control of breathing; sleep disorders; obstruction to airflow in the common diseases of upper and lower airways such as croup, bronchiolitis, asthma, cystic fibrosis, and bronchopulmonary dysplasia; restriction to lung function from disorders affecting the chest wall, the musculature, the nervous system, or lung tissue itself; congenital anomalies; accidents such as inhalation of foreign bodies, hydrocarbons, or toxic gases; secondary effects of non-pulmonary system disorders such as gastrointestinal reflux, myopathy, or cardiac dysfunction; disease of the upper respiratory tract including rhinitis and sinusitis; and so on.

One of the most serious classifications of this disease is known as diffuse scleroderma wherein the «sclerosis» (hardening of the tissue) occurs in the internal systems of the body, causing damage and widespread scarring to the skin as well as to various internal organs such as the lungs, kidneys, heart and gastrointestinal organs.

pneumonia A lung disease in which infection by a virus or bacterium causes inflammation and tissue damage.

«Future efforts to preserve or restore aging - and disease - related loss of lung function will need to take such tissue mechanical and cellular phenotypic changes into account,» the researchers wrote.

The inflammatory autoimmune disease that affects multiple organs and connective tissue in the body including the heart, brain, lungs, joints, blood vessels, skin and kidneys among others is called Systemic Lupus Erythematosus (SLE).

19 Ways to Heal Systemic Lupus Naturally The inflammatory autoimmune disease that affects multiple organs and connective tissue in the body including the heart, brain, lungs, joints, blood vessels, skin... Read More

Lung cancer is a disease characterized by uncontrolled cell growth in tissues of the lLung cancer is a disease characterized by uncontrolled cell growth in tissues of the lunglung.

Feline heartworm disease differs from the canine version in that in cats it affects primarily the lungs and, to a lesser extent, other soft tissues and thus is not really a «heart» disease.

The shelter medicine team has also been on the forefront of curbing strep zoo, a horrific infectious disease that eats away at lung tissue; a dog can be healthy in the morning and drop dead in the afternoon.

He always had an occasional cough that was considered to be due to his past heartworm disease as many dogs will have scar tissue in their lungs due to this disease, even after the disease is treated.

AAHA, AVMA, AAFP, the Companion Animal Parasite Council (CAPC) and the Center for Disease Control (CDC) strongly recommend parasite control for companion animals for many reasons, including prevention of visceral larva migrans, a condition in which parasites within a human «release larvae that migrate anywhere in the body... Organs commonly affected are the eye, brain, liver and lung, where infections can cause permanent visual, neurologic, or other tissue damage.

Common conditions addressed by soft tissue surgeons include exterior masses, serious wounds, upper airway and oral cavity diseases, surgically resectable benign and malignant tumors and surgical conditions of the heart, lungs and other internal organs.

In some cases, heartworms in cats migrate in tissues with no harm and, in other cases they infect the heart and major arteries which feed the lungs, causing significant and often fatal disease.

Asbestos fibres lodge in the lungs, irritate the tissue, and eventually bring about disease including cancer.

Asbestosis is a serious, progressive, chronic lung disease caused by the scarring of lung tissue due to asbestos exposure.