Sentences with phrase «diseases suggest targets»

«Commonalities in late stages of inherited blinding diseases suggest targets for therapy.»

Not exact matches

Clinically important findings suggest that targeting the epidermal growth factor receptor (EGFR) and the fibroblast growth factor receptor (FGFR) cellular pathways may benefit thousands of patients with this disease, according to the study published today in the journal PLOS Genetics.

The work suggests that changing levels of the PIAS1 protein and targeting this pathway could have a benefit to disease.

«What we found was, if we block mGluR5, which is the glutamate receptor we're interested in, the mice become hyper locomotive so they become able to move better than wild type mice suggesting glutamate receptors might be a good target for treating movement disorders such as Parkinson's disease.

But the new Salk research, published in the journal eLife, suggests that rapamycin could also target the neural damage associated with Leigh syndrome, a rare genetic disease, and potentially other forms of neurodegeneration as well.

«Our data suggests that targeting specific immune cell subsets at defined stages of disease may represent a better approach to therapeutic immunomodulation to improve heart failure.»

«Inflammation is associated with bone growth: A study using induced pluripotent stem cells suggests that a molecule for inflammation could be a good drug target to prevent diseased bone growth.»

Although that marker, called IL21, had not previously been associated with autoimmune diseases, the gene that produces it sits right in the stretch of DNA known to make these mice vulnerable to diabetes, suggesting that IL21 might make a drug target, says Sarvetnick.Furthermore, by giving the animals a shot of dead bacteria — similar to an immunization in humans — when they were newborns, Sarvetnick and her colleagues prevented a surfeit of CD4 + and CD8 + cells.

Overall the findings suggest that granzyme A could serve as a potential drug target for anti-inflammatory treatments for chikungunya — and perhaps also for other inflammatory diseases.

«Our findings suggest that PRMT5 is a possible prognostic factor and therapeutic target for glioblastoma, and they provide a rationale for developing agents that target PRMT5 in this deadly disease,» says co-corresponding author Robert A. Baiocchi, MD, PhD, associate professor of medicine and a hematologist at the OSUCCC — James who is also collaborating on an Ohio State effort to develop a PMRT5 inhibitor.

Already, researchers have linked noncoding DNA to Crohn disease, heart disease, multiple sclerosis, and other disorders, suggesting that enhancers could be targets for medical manipulation.

Not only does it suggest new targets for drug development, but it also puts forward new behavioral changes that may be taken on the part of the infected individual in order to decrease the chances of developing a major disease and increase longevity.

That's an important lesson, Tolar says; it suggests that future attempts to correct genetic skin diseases should focus on culture conditions that nourish these stem cells, and potentially even target them for modification.

«Although it's still early days for this line of research, these findings provoke the hypothesis that MHCII + innate lymphoid cells may be an important pathway to therapeutically target in the treatment of some chronic inflammatory diseases,» suggests Sonnenberg.

Based on these results, researchers suggest that «if post-2000 trends continue, the chance of meeting the global target of UN on this disease is lower than 1 % for males and 1 % for females worldwide.

Now a scientist reports that mice engineered to make extra follistatin, which deactivates myostatin, have four times the muscle of regular mice, suggesting a new target for drugs to fight muscle - wasting diseases such as muscular dystrophy.

The study is investigator led and has therefore focused on clinical need, targeting patients with progressive multiple sclerosis in whom most disability is incurred... The study also reports a predominant effect on neurodegenerative rather than inflammatory outcomes, suggesting a novel mechanism of action that might be suitable as combination treatment with immunomodulatory treatments... Further phase 3 studies to measure the effect of simvastatin on sustained disability, particularly in patients with non-relapsing secondary progressive and primary progressive multiple sclerosis, are clearly needed, but this trial represents a promising point from which to develop trials of progressive disease.»

The study suggests that attacking those subsets with targeted drugs may degrade the disease's ability to spread throughout the bone marrow of affected patients, the authors say.

The results suggest that, theoretically, delivering targeted, selective, and specific brain stimulation might improve some of the cognitive aspects of losing dopamine in Parkinson's disease.»

«PINK1 protein crucial for removing broken - down energy reactors: Study suggests potential new pathway to target for treating ALS, other diseases.»

Our research suggests that we may also need to think about targeting the brain to treat non-alcoholic fatty liver disease.»

This similarity suggests that researchers should target the underlying process in the different varieties of the disease, he says, for example by developing a drug to prevent dystrophin from breaking down.

«Our results suggest that heart failure would be better addressed by treatments that shut down immune cells that are both sources and targets of cytokines in the spleen and heart, instead of targeting any one cytokine,» said Sumanth Prabhu, M.D., director of the Division of Cardiovascular Disease within the UAB School of Medicine and study leader.

The finding, published in The Journal of Clinical Investigation, validates a similar discovery made by the scientists in mice two years ago and suggests a target for future therapies to treat the devastating eye disease that currently has no cure.

«While we need to better understand how these abnormally regulated metabolites activate oncogenic proteins, our intriguing discovery suggests novel therapeutic targets for this disease,» says principal investigator and study leader Arnab Chakravarti, MD, chair and professor of Radiation Oncology and co-director of the Brain Tumor Program at the OSUCCC — James.

The findings challenge the long - held theory that leukemia cells simply outperform healthy cells by living longer and suggest that targeting this «death factor» may be a viable way of combating the disease.

«These events predict a worse outcome in TNBC patients suggesting that the LINK - A pathway plays a critical role in this disease and may provide wide - ranging therapeutic treatment targets.»

«This suggests a mechanism by which drugs that target certain other neurological diseases may be effective.»

The research suggests that targeting the protein called GLUT1 could help prevent or slow the effects of Alzheimer's, especially among those at risk for the disease.

«Following the exciting discovery that dengue virus NS1 protein can directly cause vascular leak, the hallmark of severe dengue disease, we have now succeeded in disentangling the mechanisms responsible, suggesting new drug targets for inhibiting severe dengue,» says Dr. Eva Harris, the senior investigator.

One third of the target genes for which they had patient data - 32 out of 97 - were also linked to survival in women with oestrogen receptor - positive breast cancer, suggesting they play an important role in the disease.

While some are suggesting the failure of these BACE1 trials indicate that the amyloid plaque hypothesis for Alzheimer's disease may in fact be wrong, other recent research still suggests more targeted methods of inhibiting the enzyme could result in positive outcomes.

In our latest work, for example, we have found evidence of a potentially clinically useful connection of complement in mesenchymal stem cell - based therapies, suggesting that complement is a valid target for improving the viability and function of mesenchymal stem cells, which are under extensive evaluation in clinical trials for treating many inflammatory and degenerative diseases.

Their findings on telomeres, the stretches of DNA at the ends of chromosomes that protect our genetic code and make it possible for cells to divide, suggest a potential target for preventive measures against cancer, aging and other diseases.

These findings suggested two things: that if a person naturally carried a similar mutation in their MSH3 gene, they might also have reduced CAG repeat instability, and hence a better disease prognosis, and secondly, that making drugs to target MSH3 could be valuable for the treatment of Huntington's disease, assuming that instability is important.

«Usually that's useless because they are already inactive in that state, but this finding suggests we might be able to find new therapeutic approaches to target these diseases.»

«In this study, we found two genes that control levels of lipids with anti-diabetic and anti-inflammatory activity, suggesting exciting targets for diabetes and inflammatory diseases,» said co-senior author Alan Saghatelian, who holds the Dr. Frederik Paulsen Chair at the Salk Institute.

This finding suggests new targets for drugs designed to treat inflammatory diseases.

The study suggests a potential treatment target for diseases such as Crohn's disease and ulcerative colitis.

In the case of Influenza A, the loss of RNA exosome activity severely compromises viral infectivity, but also manifests in human neurodegeneration suggesting that viruses target essential proteins implicated in rare disease in order to ensure continual adaptation.

The high selectivity, and the potency with which some of these receptors promote flavivirus infection, suggest only a small number of receptors might be effectively targeted to treat these diseases.

The new research, along with an accompanying editorial by Martin C. Michel of Johannes Gutenberg University in Mainz, Germany, and Paul A. Insel of the University of California at San Diego, suggest new contributors to this near - universal problem and potential targets to treat more serious problems that affect blood vessels in the cold, such as in Raynaud's disease.

Exciting new research from the Francis Crick Institute and King's College London suggests novel targets for cancer and inflammatory diseases.

Emerging studies suggest that miRs are novel therapeutic targets for complex diseases.

In the meantime, our experience to date suggests that precise genome editing of putative targets in primary cell systems is possible, offering more human disease relevant systems than conventional cell lines.

This study leads to a better understanding of macrophage responses to infection, provides insight into disease development, and suggests targets for therapeutic intervention.

The findings, published today in Translational Psychiatry, suggest leptin deficiency may contribute to physical health problems associated with early life stress, and provide a possible target in disease prevention.

Researchers at Karolinska Institutet in Sweden now demonstrate in a paper published in Nature that a well - known family of enzymes can prevent the inflammation and thus constitute a potential target for drugs.Research suggests that microglial cells — the nerve system's primary immune cells — play a critical part in neurodegenerative diseases, such as Alzheimer's and Parkinson's.

The Centers for Disease Control and Prevention suggests setting a target weight loss goal of 1 to 2 lbs.