We can't predict which virus species will slip into eggs and sperm and provide us with the next piece of the human genome, but here is one fact that's pretty unsettling to ponder: If you put a koala retrovirus in
a dish with human cells, it can easily infect them.
Not exact matches
These techniques include:
human tissue created by reprogramming
cells from people
with the relevant disease (dubbed «patient in a
dish»); «body on a chip» devices, where
human tissue samples on a silicon chip are linked by a circulating blood substitute; many computer modelling approaches, such as virtual organs, virtual patients and virtual clinical trials; and microdosing studies, where tiny doses of drugs given to volunteers allow scientists to study their metabolism in
humans, safely and
with unsurpassed accuracy.
That would be getting close to the number of
cells in a mouse brain,» raising the distant prospect of a
human brain organoid
with cognitive and even emotional capacities, all while sitting in a lab
dish.
In addition to looking at mouse models of diabetes, the researchers also showed that exposure of
human pancreatic islet
cells — both from healthy donors and from patients
with Type 1 diabetes — to fasting - mimicking diet in a
dish stimulated insulin production.
Xu and colleagues grew S. gallolyticus in lab
dishes with several different types of
human cells.
They then put the
dishes into special chambers called bioreactors that keep them warm and in gentle motion reminiscent of a womb, encouraging the
cells to form blobs
with working neurons and many other features of a full - size
human brain.
«We culture typical skin
cell of the epidermis, such as
human keratinocytes, in our
dishes to form an artificial epidermis
with all of its natural layers,» explained Sibylle Thude, the biologist who led the investigation into the accreditation.
The investigators studied application of various doses of a common PBDE flame retardant on
human adrenal
cells in culture
dishes and compared the effects
with those of only the vehicle, the inactive substance used to deliver the chemical.
In lab
dishes, Liu's team corrected a mutation in
human cells from a patient
with an iron - storage blood disorder called hereditary hemochromatosis.
Next steps include He's collaboration
with Piedmont Atlanta Hospital to retrieve T
cells, liver cancer
cells and healthy tissue normally removed from patients during surgery, put the mouse receptor genes on these T
cells and monitor in a
dish both how those
cells now fight the tumor and react to healthy
human tissue.
But making chimeras
with human organs whose development can be studied is more likely to succeed than the technique researchers have been trying for years: coaxing stem
cells growing in lab
dishes to become three - dimensional, functional tissues and organs.
As the Joslin team reports in the journal Nature Medicine, the work began
with taking samples of both brown and white precursor
cells from four
human subjects and genetically modifying these
cells to «immortalize» them for long life in a Petri
dish.
To confirm these findings, the team infected
human cells in
dish with two forms of CMV — one of which could generate the IE2 accelerator circuit and one that could not.
Wang's team discovered that if
human lung cancer
cells in a lab
dish in the presence of the receptor were treated
with BCX, they migrated less than untreated ones.
To uncover how groups of cancer
cells achieve functional diversity (through RNA) to survive chemotherapy, Lopez - Diaz dosed
dishes of
human pre-cancer and metastatic breast cancer
cells with the cancer drug paclitaxel for a week and then removed the drug for a few weeks, mimicking the treatment cycle for a cancer patient.
The usual approach is to grow
human cells in a
dish, to infect and try to treat them there, but this is not possible
with liver
cells or hepatocytes.
For example, researchers have demonstrated that the method can be used to treat muscular dystrophy and glaucoma in mice, render
human cells grown in lab
dishes resistant to HIV, and help create food crops and livestock
with desirable traits.
HepG2
cells in 100 mm
cell culture
dishes were transfected
with pGL - MARE - Luc plasmid DNA along
with plasmid carrying the
human Bach1 gene or the empty vector pFLAG - CMV - 6c using Fugene6 (Promega).
The work, performed on
human brain
cells in a
dish, paves the way for trying the technique on the brain,
with the hope that it could treat a number of genetic conditions.
These single -
celled microbes share many characteristics
with human cells, but they can be rapidly grown in great numbers in a flask or petri
dish, and they have a life cycle and genome that make their genetics easier to study.
With the exception of wounds, diarrhea, and dermatitis, we have only observed the effectiveness of colloidal silver against germs on Petri
dishes or on
human cells that are grown on Petri
dishes, which are not enough to show that they are effective.
There are also petri
dish studies that suggest gamma oryzanol may help lower cholesterol, and along
with other compounds found in the rice bran, which is what makes brown rice brown, may inhibit
human cancer
cell growth through antioxidant means, anti-proliferative and pro cancer
cell suicide mechanisms, immune system modulation, and increasing barrier protection, but again this is all just in test tubes, not people.