Sentences with phrase «disrupt normal genes»
One approach is to deliver a working copy of the entire gene within a virus, but this method can disrupt normal genes.
http://www.sciencemag.org/
Many patients suffering from Rare Disease harbour genomic variants (sequence variants or copy number variants) that by disrupting normal gene expression lead to disease.
Not exact matches
The L1 genes can jump to new positions, disrupting the normal activities of cells if they land in the middle of important genes.
Myc is a cancer - causing gene responsible for disrupting the normal 24 - hour internal rhythm and metabolic pathways in cancer cells, found a team led by researchers from the Perelman School of Medicine at the University of Pennsylvania.
The molecules are critical to normal development: When the genes for certain of these molecules are experimentally erased, the eggs made by female mice are invariably defective, and the errors fatally disrupt the normal choreography of egg maturation.
Scientists believe inbreeding disrupts the complex mix of genes that is needed to produce «normal» sperm.
Simon's strategy is to compare the effects of a drug on a normal strain of yeast and a strain with a mutation in one of the many genes that affect normal cell division - a property that is disrupted in cancerous cells.
The effects of disrupting the «silent» genes revealed in these studies may be masked by the activity of related genes, or because their mutations produce defects that are not readily apparent in casual observation under normal laboratory conditions.
The researchers not only had to figure out how SLC16A11 performed in normal circumstances, but also then determine how mutations in the gene disrupted that function.
«By mapping the breakpoints, we were able to identify genes that were disrupted in patients with birth defects, which suggests that these genes play a key role in normal brain development,» she said.
The alternate ky variant of the CBD103 gene disrupts the normal function of the CBD103 gene allowing for agouti (A locus) gene expression and the inhibition of black pigment synthesis.