Sentences with phrase «disrupting cellular function»

Researchers determined that the bioactive compounds in green tea and red wine (EGCG and resveratrol) distorted the shape of the amyloid balls, preventing them from binding with prions and disrupting cellular function.

This keeps toxins and germs out of your blood and prevents them from making you sick or disrupting cellular function.

Some of the PCBs are not broken down in this way, and their continued stimulation of AHR2 disrupts cellular functions, leading to toxicity.

Studies show that an estimated 81 % of Americans studied have tested positive for BPS, and a 2013 study has found that even trace levels of BPS can disrupt cellular functioning (source), potentially leading to many of the same health risks as BPA.

Not exact matches

Calcium, however, puts a strain on cells — it is known to hinder protein - folding and metabolism when it accumulates — disrupting normal cellular function.

A challenge in developing iron chelators for use in human therapy is to reduce iron accumulation without disrupting iron - dependent cellular functions.

Certain particle compounds may directly generate ROS in vivo because of their surface chemistry (eg, metals, organic compounds, and semiquinones) or after bioactivation by cytochrome P450 systems (eg, polycyclic aromatic hydrocarbon conversion to quinones).6, 290 a, 290 b A particle surface or anions present on otherwise more inert particles may disrupt iron homeostasis in the lung and thereby also generate ROS via Fenton reactions.291 Other PM constituents may do so indirectly by the upregulation of endogenous cellular sources (eg, nicotinamide adenine dinucleotide phosphate [NADPH]-RRB- oxidase) 292,293 or by perturbing organelle function (eg, mitochondria) by taken - up PM components.261 Particle stimulation of irritant and afferent ANS fibers may also play a role in local and systemic oxidative stress formation.294 Given the rich antioxidant defenses in the lung fluid, secondarily generated oxidization products of endogenous molecules (eg, oxidized phospholipids, proteins) or a reduction in endogenous antioxidants per se may be responsible at least in part for the state of oxidative stress in the lungs (along with instigating the subsequent cellular responses) rather than ROS derived directly from PM and its constituents.

These results support data suggesting that excess HS oligosaccharides impair function of cellular adhesion molecules and disrupt normal polarization and orientation of cultured MPSIIIB mouse astrocytes or neural stem cells [52].

Herbicides can disrupt normal cellular mitochondrial function and have been shown to cause insulin resistance in animals.

Aβ is believed to penetrate neuronal plasma membranes, where it leads to lipid peroxidation.10 It has also been implicated in deactivating a subunit of the pyruvate dehydrogenase complex, thereby inhibiting conversion of pyruvate to acetyl CoA and the eventual production of cellular energy as ATP.32 Another way Aβ affects glucose metabolism in the brain is that fragments of Aβ disrupt insulin signaling by binding to neuronal synapses, which alters their shape and function.15, 38 Insulin receptors are abundant at synapses, so if the integrity of the synapse itself has been compromised, the receptors won't function effectively.

When heavy metals reach the blood in their free forms, they disturb normal cellular and metabolic processes as well as disrupt hormonal balance and also immune function.