Sentences with phrase «disrupting gene control»

«The fact that the genetic code can simultaneously write two kinds of information means that many DNA changes that appear to alter protein sequences may actually cause disease by disrupting gene control programs or even both mechanisms simultaneously,» said Stamatoyannopoulos.

Not exact matches

This interaction explains how major HSF symptoms arise when mutation of the CMG2 gene disrupts the ability of the CMG2 protein to control the levels of collagen VI, which then over-accumulates and produces the painful and disfiguring symptoms of the disease.

Many of the infected cells died, and others showed disrupted expression of genes that control cell division, indicating that new cells could not be made effectively.

Using a new method, PolyStrat, which prioritizes variants disrupting evolutionarily conserved, functional regions, we found four significantly associated genes when comparing just 592 cases to 560 controls.

Now that scientists understand how these genes control the heart, they can begin to piece together how heart disease disrupts this regulation.

We identify 23 genes that, when disrupted in mouse, modify the ability of tumour cells to establish metastatic foci, with 19 of these genes not previously demonstrated to play a role in host control of metastasis.