Sentences with phrase «disrupts gene functioning»

Frequently insertions / deletions alter the open reading frame (ORF) of the target gene, disrupting the gene function downstream of the DSB.

We analyzed mRNA processing in seven zebrafish lines with mutations expected to disrupt gene function, generated by CRISPR / Cas9 or ENU mutagenesis methods.

We estimate that 42 % of our cohort carry pathogenic DNMs in coding sequences; approximately half of these DNMs disrupt gene function and the remainder result in altered protein function.

Not exact matches

The researches found that the transgene was inserted into an active region of the genome, thereby disrupting the coding sequence and ultimately the function of the plants own OsAux1 gene.

This can disrupt the functioning of other genes and create novel proteins that have never been in the food supply and could create toxins and allergens in foods.

When similar analysis was performed on the db mice, it was found that the disrupted db gene was responsible for encoding a protein that functions as a leptin receptor: When it binds circulating leptin at the cell surface, it sets in motion a biochemical cascade inside the cell.

In the current study, researchers analyzed 48 ethnically diverse patients diagnosed with schizophrenia, looking at symptom sets in patients found to have rare or previously unknown changes in the DNA code of the four genes that disrupted brain function.

The researchers also assessed the necessity of numerous genes in the microbe by inserting foreign genetic material, called transposons, to disrupt their function.

At first, the extra letters were slipped into the bacteria far from working genes, to avoid disrupting their function.

Children with gene mutations that disrupt the functioning of A20 are more likely to have asthma and allergies, so Bart Lambrecht of Ghent University in Belgium and his team wondered whether A20 may be involved helping endotoxins to train our immune systems.

Researchers checked the genomes of 150 patients with schizophrenia and those of 268 healthy people, looking for large duplications and deletions of genetic material that disrupted the function of a gene.

More than 90 percent of the plants» genes are disrupted by the ten million mutations catalogued in the collection, making it a powerful resource for studying the function of nearly any wheat gene.

The study suggests that, in HFS, the mutation of the CMG2 gene disrupts the function of the protein, leading to accumulation of collagen VI in various parts of the body.

The Johns Hopkins team looked for ways to knock down SCN function by targeting and disabling certain genes that disrupt only the formation of the SCN clock.

Since proper functioning of the fat body is essential for the development of the female reproductive system after a blood meal, identifying which miRNAs are important to fat body functions, and what specific genes they target, can help design ways to manipulate the levels of microRNA or their targets, affect their interactions, disrupt mosquito reproduction, and thus prevent the spread of diseases the mosquitoes transmit.

This disrupts the gene, stopping it from functioning.

Children with gene mutations that disrupt the functioning of an enzyme called A20 are more likely to have asthma and allergies, so Bart Lambrecht of Ghent University in Belgium and his team wondered whether A20 may be involved in helping endotoxins train our immune systems.

The researchers predicted that if they removed this viral DNA from the cell, the transcription factors would not function properly, potentially disrupting genes involved in the innate immune response.

Using this «subdued» CRISPR / Cas9 system, the researchers were able to disrupt each of T. gondii's 8,158 genes and study their individual functions.

Based on studies of other genes related to FOXP2, the authors suggest that the loss of functioning protein from one copy of this gene might disrupt the proper growth of key speech and language structures in the brain.

As a result, the protein encoded by the affected gene has a patch, where only the building block glutamine can be found, disrupting that proteinâ $ ™ s usual functions in the body.

For example, in the case of the protein SIN3A, a regulator of gene transcription, the small molecule that covalently binds to its reactive lysine blocks the protein's function by disrupting SIN3A's interaction with another protein, TGIF1 — an interaction implicated in some invasive breast cancers.

Researchers make knockout mice by disrupting the function of individual genes across the animal's genome.

«Inherited genetic conditions often result because the function of a gene is disrupted.

Herein, we identify 382 of the 482 M. genitalium protein - coding genes as essential, plus five sets of disrupted genes that encode proteins with potentially redundant essential functions, such as phosphate transport.

The microbe is particularly well suited for testing the functions of individual plant genes because bacterial DNA disrupts the genome at the point of insertion.

By combining pieces of different genes, fusion genes can lead to production of abnormal proteins that disrupt cell function.

Following up on findings from a an earlier genome - wide association study (GWAS) of type 2 diabetes (T2D) in Latinos, researchers from the Broad Institute of MIT and Harvard and Massachusetts General Hospital (MGH) traced an association detected in that study to variants in a specific gene, SLC16A11, and uncovered two distinct mechanisms by which those variants disrupt the gene's function in liver cells, possibly contributing to the pathogenesis of T2D.

The researchers not only had to figure out how SLC16A11 performed in normal circumstances, but also then determine how mutations in the gene disrupted that function.

Loss - of - function mutations can disrupt both copies of a given gene in humans and phenotypic analysis of such «human knockouts» can provide insight into gene function.

Naturally occurring loss of function (LoF) mutations that disrupt the gene's function or expression provide an opportunity to understand the long term consequences of genetic deficiency in humans.

The alternate ky variant of the CBD103 gene disrupts the normal function of the CBD103 gene allowing for agouti (A locus) gene expression and the inhibition of black pigment synthesis.

Muscular dystrophy in dogs is caused by an inherited mutated dystrophin gene that disrupts the dystrophin protein production, resulting in loss of muscle function.