Sentences with phrase «distant tissues»

They travel through the bloodstream to impact the expression of genes on distant tissues, which impacts how our bodies function.

McDonald and close collaborators from Memorial Sloan Kettering Cancer Center and Johns Hopkins University School of Medicine sought to understand how pancreatic cancer progresses from a primary tumor in the pancreas to metastatic disease in distant tissues.

Microvascular endothelial cells play a critical role in tumor progression and metastasis by forming capillary networks that encourage tumor growth and by promoting the attachment of circulating tumor cells to the vascular wall of distant tissues.

Scientists know a great deal about how tumors originate and develop, but relatively little about how cancer manages to metastasize and invade distant tissues and organs.

The location of blemishes and other changes on your face's skin is a result of a distinct relationship with distant tissues or organs.

This process requires a fundamental change in the character of cells within the primary tumor, insofar as members of a localized cell mass must be converted into actively migrating cells that invade into the surrounding tissue and blood vessels, and finally settle in distant tissues.

Recently, skeletal muscle has been recognized as an endocrine tissue with the capacity to secrete cytokines and growth factors, known as myokines, which can act on distant tissues.

Most of the 580,000 U.S. cancer deaths each year are caused by complications from the spread of cancer to distant tissues and organs, rather than from the primary tumor itself.

«The primary tumor sends signals to distant tissue and organs to prepare the soil for metastasis,» Lu said.

«Circulating tumor cells (CTCs) have been shed by the original tumor and entered the bloodstream — they can then form into new tumors if they lodge in distant tissue,» Wang says.

Metastasis is a dangerous phenomenon in which cancer cells separate from the original tumor, move into the bloodstream or lymphatic system, anchor in a distant tissue or organ, and begin a new tumor.

Specifically, we aim to investigate how muscle - specific genetic interventions can regulate lifespan, the role of myokines in mediating the crosstalk between muscle and other tissues, and the cellular and molecular responses induced in distant tissues.

They drip, if you will, into the bloodstream where they travel to the distant tissues and organs, where they then bind to the tissues» and organs» specific cell sites called receptors.

They tend to invade surrounding tissues and metastasize (spread to distant tissues) even when the primary tumor is very small.