Sentences with phrase «distinct cell types in»

The Penn team unexpectedly found that what they thought were two irreversibly differentiated and distinct cell types in the kidney could convert to each other.

Each is a protein that serves to flag a distinct cell type in the mammalian brain.

Not exact matches

In the clearest possible case, the ANT - OAR cell would differ from a zygote on all of the parameters noted above: The ANT - OAR cell would have a pattern of gene expression that is clearly distinct from a zygote; it would generate a homogeneous population of cells rather than multiple cell types; it would undergo simple cleavage divisions and not produce any multicellular structures.

This finding reinforced the notion that, in addition to their distinct physiological functions, the two cell types have very different roles in disease.»

«Each area of the brain is different with distinct cell types and connectivity, so if we can confirm that one area of circuitry is more involved in a particular symptom than another, we may eventually be able to treat a depression patient more efficiently than treating everyone the same way.»

Two different types of dendritic cells in the immune system present antigen in different ways to elicit distinct immune responses.

The research team with international collaborators analysed more than 100 patient samples from ovarian and other cancer types to discover a distinct population of cells found in some tumours.

For us, the question in this study was, do exhausted cells represent a distinct type of T cell or are they merely a «groggy» version of functional T cells?»

In addition, many niches contain different stem cell types, each necessary to produce the distinct types of cells needed for tissue renewal.

As it turns out, the missing link was a previously unknown type of light - sensitive cell in the human eye, distinct from the familiar rods and cones that are responsible, respectively, for night and color vision.

She adds that it is also unclear why distinct patterns of these sites are observed in different cell types and under different drug treatments.

«Distinct wiring mode found in chandelier cells: Researchers identify the wiring process of a unique type of inhibitory cells implicated in several diseases.»

Because these receptors are restricted to two distinct MSN populations, this postulate demands that synaptic plasticity be unidirectional in each cell type.

Five days after fertilization, two distinct cell types are visible in the developing embryo, which is now called a blastocyst.

The mechanism used by Notch to regulate Myc in B cells is distinct from the mechanism used in other cell types, such as T cells, where Notch also regulates Myc.

«Conversely, the necrotic part of the tumor is driven by a distinct set of glioma stem cells utilizing the BIM1 pathway and are characterized by a mesenchymal, inflammatory cell type dependent on glucose metabolism in the absence of oxygen.

In wild - type, retinal ganglion cell layer (GCL), inner nuclear layer (INL), inner plexiform layer (IPL), and nuclear layers of rod and cone photoreceptors are distinct, and rod outer segment (OS) is observed at the outer-most layer of the retina.

I think what we are seeing with this study is just the tip of the iceberg, where the process of protein production is probably quite different in distinct cell types.»

Monocytes, a distinct type of cell that is not usually in the brain in large numbers, are lit up red.

Simon's favorite approach is to examine the context of the cell - properties that make distinct cell types unique in their normal and cancerous states.

We generate high - resolution 3D models of the spatial organization of the genomes of distinct eukaryotic cell types in interphase to identify differences in the chromatin landscape.

Among the strengths of the study: instead of using just one method to deplete macrophages, the researchers used nine distinct methods to deplete different myeloid cells in various locations, allowing them to pinpoint the most important cell type and its primary location of action.

Though iPS cells and hESCs are both pluripotent and virtually infinite in supply, there are distinct advantages and disadvantages associated with each cell type.

In the early 1970s, the immunology community was just beginning to coalesce around a model of immunity comprising two distinct types — one mediated by B cells and the other by T cells.

«It's fascinating that it's so complicated», says Gerard, «there is a code we don't yet understand that differs from tissue to tissue — the number of chemokines and cytokines is distinct in each tissue type and the types of cells that enter and exit the tumour also differ».

Very little is known on SAC signaling in normal tissues in vivo, and whether distinct cell types exhibit differences in SAC activation.

To replicate the cell interactions in the developing heart, the scientists developed a novel method of growing two distinct cell types together.

Following up on findings from a an earlier genome - wide association study (GWAS) of type 2 diabetes (T2D) in Latinos, researchers from the Broad Institute of MIT and Harvard and Massachusetts General Hospital (MGH) traced an association detected in that study to variants in a specific gene, SLC16A11, and uncovered two distinct mechanisms by which those variants disrupt the gene's function in liver cells, possibly contributing to the pathogenesis of T2D.

Countering the prevailing theory that cellular hydrogen peroxide signaling is broad and non-specific, Whitehead Institute scientists have discovered that this reactive oxygen species (ROS) in fact triggers a distinct signal transduction cascade under control of the mitochondrial respiratory chain — the Syk pathway — that regulates transcription, translation, metabolism, and the cell cycle in diverse cell types.

Biomedical engineers at Case Western Reserve University in Cleveland, Ohio, and Worcester Polytechnic Institute in Worcester, Mass. are growing tracheas by coaxing cells to form three distinct tissue types after assembling them into a tube structure - without relying on scaffolding strategies currently being investigated by other groups.

The latter work addresses questions including whether infection with different serotypes is associated with distinct types of T cell responses, whether any HLA alleles are associated with pathogenesis or protection, and whether vaccination with a formulation in clinical trials is associated with T cell responses similar to those following infection that might serve as correlates of protection.

The generally held view of these processes is that neurotransmitter - induced modulation of the most widely expressed Ca2 + channels in these cells (N -, P / Q - and L - type) follows two distinct pathways: a direct membrane - delimited Gi / o - protein - induced inhibition of N - and P / Q - type and a remote cAMP - mediated facilitation of L - channels.

For her dissertation, Prerana developed several bacTRAP transgenic mouse lines to characterize molecularly distinct cortical pyramidal cell types, and focused on layer 2/3 pyramidal cell population in the prefrontal cortex that moderate stress induced depression related behavior.

Dissociable brain circuits and cell - types are thought to preferentially participate in distinct learning mechanisms.

«Jekyll and Hyde» Protein Offers New Route to Cancer Drugs (09/27/2013) Researchers in Dr. Mark Bedford's lab collaborated on a study that identified distinct types of arginine methylation marks on E2F - 1, a protein with opposing roles in both cell proliferation and apoptosis.

As shown in Fig. 2B, the distinct morphologies of three types of PC3 clones were obvious at 2 weeks after single - cell plating.

In the breast, cancer stem cells and normal stem cells can arise from different cell types and tap into distinct yet related stem cell programs, according to Whitehead Institute researchers.

Slowing such overturning by reducing the horizontal differential heating could tend to allow heat to build up at lower levels until the lapse rate is more favorable to localized vertical overturning (LVO)(The two forms of overturning are not always completely distinct or separate; for example, the Hadley cell, Walker, and monsoon circulations, as well as extratropical storm track activity (developing from baroclinic instability (Rossby wave phenomena)-RRB- are driven and organized in part by horizontal differential heating, but in the ascending portions of these circulations, cumulus - type convection can occur).