Sentences with phrase «distinct gene set»

SAP domain - dependent Mkl1 signaling stimulates proliferation and cell migration by induction of a distinct gene set indicative of poor prognosis in breast cancer patients.

However, the MIT team adapted it to randomly turn on or off distinct gene sets across large populations of cells, allowing the researchers to identify genes that protect cells from a protein associated with Parkinson's disease.

Not exact matches

«Although we saw some of the hallmark characteristics of bilateral growth and development, we don't believe Dickinsonia was a precursor to today's bilaterians, rather that these are two distinct groups that shared a common set of ancestral genes that are present throughout the animal lineage,» Evans said.

Curious about the possibility of circular RNAs contributing to cancer, Pandolfi and his colleagues set out to see if they could detect relevant changes in tumors known to harbor distinct fusion proteins, which result when different chromosomes abnormally join together, melding two separate genes into a new centaur - like gene.

The gene mutations driving cancer have been tracked for the first time in patients back to a distinct set of cells at the root of cancer — cancer stem cells.

The authors next took 997 tumors in the discovery set, integrated copy number and gene expression data, and performed clustering analyses to identify subgroups of tumors with distinct features and clinical outcomes.

Microarray analysis revealed temperature - dependent expression of distinct sets of genes, as well as 700 A. fumigatus genes not present or significantly diverged in the closely related sexual species Neosartorya fischeri, many of which may have roles in the pathogenicity phenotype.

The researchers compared the sequence to that of other sequenced methanogens to identify a distinct set of genes characteristic of archaeal methanogens.

While the small changes in lineage transcription observed in our data set would be consistent with a stochastic model, the ES cell model described in Figure 9 would require both cross-repression and additional positive feedback loops to drive these random changes in gene expression down multiple distinct routes.

It is often useful to deliver distinct functions to separate genomic loci, such as, activation of a set of genes and repression of another set of genes.

More recently, it has been suggested that the contrasting attributes of gene compactness, GC content and the length of the intronic and intergenic sequences in Hkg and Tsg might be involved in chromatin mediated regulation for maintaining distinct expression patterns in the gene sets [29].