Sentences with phrase «distinct phenotype»

Some original cat breeds that have a distinct phenotype that is the main type occurring naturally as the dominant domesticated cat type in their region of origin are sometimes considered subspecies and in the past received names as such, although this is no longer supported by feline biologists.

Our data also demonstrated that chronic treatment with standard antidepressant medications, fluoxetine and imipramine was able to attenuate the distinct phenotype of stress - susceptible mice.

In these analyses, six of 90 F1 progeny (∼ 7 %) showed a distinct phenotype compared to the haploid parental strain XL280 and the remaining 84 progeny showed no phenotypic differences from the wild - type (Figure 3A and Figure S3).

Resulting attractors point to distinct phenotypes whose relevance is underlined by their differential drug sensitivity.

Latent class analysis (LCA) has frequently been used to identify qualitatively distinct phenotypes of disordered eating.

Not exact matches

However, with the development of phylogenetic analyses, we can see speciation at the genetic level (i.e. highly reduced or absent interbreeding between subpopulations) without the distinct morphological differences one would require if phenotypes were the only measure.

But by hierarchical clustering of observed alterations in endocytosis, the researchers identified two distinct cancer phenotype clusters, one marked by mutations in the oncogene KRAS in mesenchymal cells and the other by changes in epithelial cells.

They could show that there are distinct signatures of these phenotypes among these BMI categories.

Diagram indicating associations among genetic and environmental factors reduce and their interactions with intermediate phenotypes to yield distinct pathophenotypes.

Clearly, in this particular disorder, the common phenotype is misleading, suggesting a single disease as its cause when, in fact, the pathophenotype comprises multiple genetically distinct diseases.

In general, modularity refers to a group of physically or functionally linked nodes (in this case molecules) that work together to achieve a distinct functional phenotype.

Because the phenotypes were distinct in these knockout mouse models with respect to spontaneous cage activity and fast muscle isometric contractile characteristics, we can conclude that the roles of IL - 15Rα and IL - 15 in vivo are distinct with regard to muscle function.

The team found that ccRCC tumors fall into different evolutionary subtypes that are associated with distinct clinical phenotypes.

We report a variety of biallelic effects on organismal phenotype attributable to combinations of recessive Xpd alleles, including the following: (i) the ability of homozygous lethal Xpd alleles to ameliorate a variety of disease symptoms when their essential basal transcription function is supplied by a different disease - causing allele, (ii) differential developmental and tissue - specific functions of distinct Xpd allele products, and (iii) interallelic complementation, a phenomenon rarely reported at clinically relevant loci in mammals.

We recently reported that CD8 (+) T cells responding to innate - like IL - 12 + IL - 18 stimulation and co-expressing the transcription factor Eomesodermin (Eomes) and KIR / NKG2A membrane receptors with a memory / EMRA phenotype may represent a new, functionally distinct innate T cell subset in humans.

Taking in account the opposing phenotypes of Drosophila plin1 and plin2 loss of function regarding to lipid droplet size, it is intriguing to speculate that individual W01A8.1 splice forms may support distinct functions as well.

4 full length infectious clones with distinct biological phenotypes derived from a single individual infected with HIV.

Resident macrophages from the same lineage, such as liver Kupffer cells, brain microglia, epidermal Langerhans cells, lung alveolar macrophages..., display tissue - specific phenotypes, perform tissue - specific functions and have distinct gene expression profiles.

Palmitate and oleate have distinct effects on the inflammatory phenotype of human endothelial cells.

Microarray analysis revealed temperature - dependent expression of distinct sets of genes, as well as 700 A. fumigatus genes not present or significantly diverged in the closely related sexual species Neosartorya fischeri, many of which may have roles in the pathogenicity phenotype.

The TNF family molecules LIGHT and lymphotoxin ab induce a distinct steroid - resistant inflammatory phenotype in human lung epithelial cells.

We report here that, despite their phenotypic and cytolytic similarities, Ly49 + CD8 + T cells and conventional Ly49 - CD44high memory - phenotype CD8 + T cells present strikingly distinct features.

Results from recent GWAS studies have identified over 50 distinct SNP loci associated with either pigmentation phenotypes or susceptibility to melanoma.

Many psq mutant alleles have been recovered that show distinct embryonic and adult phenotypes.

We describe a distinct SCN1A phenotype, early infantile SCN1A encephalopathy, which is readily distinguishable from the well - recognized entities of Dravet syndrome and genetic epilepsy with febrile seizures plus.

Mutants in these kinases displayed distinct phosphoproteomic disruptions, consistent with differences in their phenotypes.

This report expands the phenotype of older patients with BRPS; common emerging features include severe intellectual disability (11/12), poor / absent speech (12/12), autistic traits (9/12), distinct face (arched eyebrows, prominent forehead, high - arched palate, hypertelorism and downslanting palpebral fissures), (9/12), hypotonia (11/12) and significant feeding difficulties (9/12) when young.

ETV6 (TEL)- AML1 pre-B acute lymphoblastic leukaemia cells are associated with a distinct antigen - presenting phenotype.

Our data identify a distinct senescence response and provide a mechanism by which mitochondrial dysfunction can drive aging phenotypes.

Feline caliciviruses (FCVs) isolated from cats with virulent systemic disease possess in vitro phenotypes distinct from those of other FCV isolates.

Unlike the genetically distinct, relatively late onset XLPRA1 that is described below, the phenotype associated with the frameshift mutation in XLPRA2 is very severe and manifests during retinal development.